Search results for "basic research"
showing 10 items of 76 documents
MORT1/FADD is involved in liver regeneration
2006
AIM: To explore the role of the adaptor molecule in liver regeneration after partial hepatectomy (PH). METHODS: We used transgenic mice expressing an N-terminal truncated form of MORT1/FADD under the control of the albumin promoter. As previously shown, this transgenic protein abrogated CD95- and CD120a-mediated apoptosis in the liver. Cyclin A expression was detected using Western blotting. ELISA and RT-PCR were used to detect IL-6 and IL-6 mRNA, respectively. DNA synthesis in liver tissue was measured by BrdU staining. RESULTS: Resection of 70% of the liver was followed by a reduced early regenerative response in the transgenic group at 36 h. Accordingly, 36 h after hepatectomy, cyclin A …
Nitroglycerine causes mitochondrial reactive oxygen species production: In vitro mechanistic insights
2007
Background Nitroglycerine (GTN) is an organic nitrate that has been used for more than 100 years. Despite its widespread clinical use, several aspects of the pharmacology of GTN remain elusive. In a recent study, the authors of the present study showed that GTN causes opening of the mitochondrial permeability transition pore (mPTP) and mitochondrial production of reactive oxygen species (ROS). Objective In the present study, it was tested whether GTN-induced ROS production depends on mitochondrial potassium ATP-dependent channel or mPTP opening, and/or GTN biotransformation. Methods and results Isolated rat heart mitochondria were incubated with succinate (a substrate for complex II) and GT…
Role of apoptosis in autoimmunity.
2004
Autoimmune diseases are characterized by the activity of autoreactive lymphocytes that produce antibodies targeting self tissue or organ for destruction. Although the pathogenesis of these diseases is poorly understood, during the past two decades basic research has indicated apoptosis as the pivotal molecular mechanism leading to autoimmunity. Recently cytokines have been invoked in the regulation of the apoptosis-related factors and death receptors in autoimmune target destruction. These research advances have contributed to the identification of mechanisms controlling autoimmunity for defining novel therapeutic strategies.
Large-angle production of charged pions with incident pion beams on nuclear targets
2009
Measurements of the double-differential pi(+/-) production cross section in the range of momentum 100 <= p <= 800 MeV/c and angle 0.35 <=theta <= 2.15 rad using pi(+/-) beams incident on beryllium, aluminum, carbon, copper, tin, tantalum, and lead targets are presented. The data were taken with the large-acceptance hadron production (HARP) detector in the T9 beam line of the CERN Proton Synchrotron. The secondary pions were produced by beams in a momentum range from 3 to 12.9GeV/c hitting a solid target with a thickness of 5% of a nuclear interaction length. The tracking and identification of the produced particles was performed using a small-radius cylindrical time projection chamber place…
Search for Anomalous Production of Events with a Photon, Jet, b-quark Jet, and Missing Transverse Energy
2009
We present a signature-based search for the anomalous production of events containing a photon, two jets, of which at least one is identified as originating from a b quark, and missing transverse energy ((sic)(T)). The search uses data corresponding to 2.0 fb(-1) of integrated luminosity from p (p) over bar collisions at a center-of-mass energy of root s = 1.96 TeV, collected with the CDF II detector at the Fermilab Tevatron. From 6.697 47 x 10(6) events with a photon candidate with transverse energy E-T > 25 GeV, we find 617 events with (sic)(T) > 25 GeV and two or more jets with E-T > 15 GeV, at least one identified as originating from a b quark, versus an expectation of 607 +/- 113 event…
Comparison of large-angle production of charged pions with incident protons on cylindrical long and short targets
2009
The HARP Collaboration has presented measurements of the double-differential pi(+/-) production cross section in the range of momentum 100 MeV/c <= p <= 800 MeV/c and angle 0.35 rad <=theta <= 2.15 rad with proton beams hitting thin nuclear targets. In many applications the extrapolation to long targets is necessary. In this article the analysis of data taken with long (one interaction length) solid cylindrical targets made of carbon, tantalum, and lead is presented. The data were taken with the large-acceptance HARP detector in the T9 beam line of the CERN proton synchrotron. The secondary pions were produced by beams of protons with momenta of 5, 8, and 12GeV/c. The tracking and identific…
Measurements of forward proton production with incident protons and charged pions on nuclear targets at the CERN Proton Synchroton
2010
Measurements of the double-differential proton production cross-section d(2 sigma)/dpd Omega in the range of momentum 0.5 GeV/c <= p < 8.0 GeV/c and angle 0.05 rad <= theta < 0.25 rad in collisions of charged pions and protons on beryllium, carbon, aluminium, copper, tin, tantalum, and lead are presented. The data were taken with the large acceptance HARP detector in the T9 beam line of the CERN Proton Synchrotron. Incident particles were identified by an elaborate system of beam detectors and impinged on a target of 5% of a nuclear interaction length. The tracking and identification of the produced particles was performed using the forward spectrometer of the HARP experiment. Results are o…
The Jyväskylä Accelerator Laboratory
2014
The Jyvaskyla Accelerator Laboratory is a national center for nuclear and accelerator-based research and education. It is an integral part of the Department of Physics, University of Jyvaskyla. The Accelerator Laboratory and the Department Physics were moved to the current site in the early 1990s, as described in the previous Laboratory Portrait published in 1991 [1]. Since then the research program of the laboratory has been structured around the main instruments and research fields, which share the available beam time. The present laboratory layout is shown in Figure 1. In addition to basic research in nuclear and accelerator based materials physics, beam time is reserved for commercial s…
Has pharmaceutical research become more scientific?
1996
Pharmaceutical research continues to be highly empirical, despite some recent writings arguing that it has become more scientific. Contrary to a study asserting that Mevacor, Tagamet, and Capoten demonstrate the success of targeted research, these drugs were discovered only after many years of following leads. Two hypotheses implied by the proposition that pharmaceutical research has become more scientific are tested. The first hypothesis is that the uncertainty of research has fallen. The second is that the number of publications by scientists in the industry has increased. Both are rejected.
Measurement of top quark polarization in tt¯ lepton+jets final states
2017
Department of Energy (USA); National Science Foundation (USA); Alternative Energies and Atomic Energy Commission and National Center for Scientific Research/National Institute of Nuclear and Particle Physics (France); Ministry of Education and Science of the Russian Federation (Russia); National Research Center "Kurchatov Institute" of the Russian Federation (Russia); Russian Foundation for Basic Research (Russia); Carlos Chagas Filho Foundation for the Support of Research in the State of Rio de Janeiro (Brazil); Department of Science and Technology (India); Administrative Department of Science, Technology and Innovation (Colombia); National Council of Science and Technology (Mexico); Natio…