Search results for "being"

Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetes

2022

Skeletal muscle physiology remains of paramount importance in understanding insulin resistance. Due to its high lipid turnover rates, regulation of intramyocellular lipid droplets (LDs) is a key factor. Perilipin 5 (PLIN5) is one of the most critical agents in such regulation, being often referred as a protector against lipotoxicity and consequent skeletal muscle insulin resistance. We examined area fraction, size, subcellular localization and PLIN5 association of LDs in two fiber types of type 2 diabetic (T2D), obese (OB) and healthy (HC) individuals by means of fluorescence microscopy and image analysis. We found that T2D type II fibers have a significant sub-population of large and inter…

DNA Fingerprinting as a Tool of Paternity Testing in Germany

1991

Soon after the discovery of the ABO blood groups by Landsteiner their forensic application was suggested by Max Richter at the 74. Versammlung Deutscher Naturforscher und Arzte at Karlsbad (Karlovy Vary) in 1902 [1], Landsteiner’s Nobel lecture “Uber individuelle Unterschiede des menschlichen Blutes” in 1930 [2] provided a landmark on the path towards the discovery of so-called hypervariable minisatellite regions of human DNA by Alec Jeffreys in 1985 [3]. Since the individual patterns of any human being seemed to be unique it is well understood that this achievement was immediately welcomed with great enthusiasm by the scientific community and the public opinion. Soon thereafter, however, s…

Technologies to Support Learning, Well-Being, and Communication

2013

Authenticity and well-being on social network sites: A two-wave longitudinal study on the effects of online authenticity and the positivity bias in S…

2014

In offline settings, authentic behavior has frequently been linked to increased well-being. Social network sites (SNSs) provide a new venue for authenticity, yet the effects of online authenticity are largely unknown. The present study investigated the reciprocal effects of authenticity on SNSs and the psychological well-being of SNS users in a two-wave longitudinal study (N=374). The results demonstrate that online authenticity had a positive longitudinal effect on three indicators of subjective well-being. The data further illustrate that this beneficial effect of SNS use is not equally accessible to all users: participants with low levels of well-being were less likely to feel authentic …

Validation of the Hungarian PHQ-15. A latent variable approach

2021

Somatic symptoms without a clear-cut organic or biomedical background, also called "medically unexplained" or "somatoform" symptoms, are frequent in primary and secondary health care. They are often accompanied by depression and/or anxiety, and cause functional impairment. The Patient Health Question-naire Somatic Symptom Scale (PHQ-15) was developed to measure somatic symptom distress based on the frequency and bothersomeness of non-specific somatic symptoms. The study aimed to (1) evaluate the Hungarian version of the PHQ-15 from a psychometric point of view; (2) replicate the bifactor structure and associations with negative affect described in the literature; and (3) provide the Hungari…

National identity predicts public health support during a global pandemic

2022

Funder: Research Council of Norway through its Centres of Excellence Scheme, FAIR project No 262675

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

2015

Contains fulltext : 155360.pdf (Publisher’s version ) (Closed access) Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91,462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in ~30 062 and 7964 coffee consumers of European and African-American ancestry, respectively. Studies from both stages were combined in a trans-ethnic meta-analysis. Confirmed loci were examined for putative functional and b…

Higher education for a better life: Canada in international context

2015

International audience; This study examines the impact of higher education on the wellbeing of Canadians in international context using single- and multi-level models examined separately for women and men. The results indicate that the relationship between higher education and wellbeing differs substantially between countries, with Canada standing out as an unusual case.

Higher learning for happiness? The non-economic benefits of higher education

2015

International audience; This project examines the impact of higher education on wellbeing in Canada and internationally using the capability approach. The focus is theoretical and empirical: The conceptual conclusions and statistical results are compared to those of human capital and utilitarian approaches, and the implications for higher education research in Canada are explored.

Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990-2019: a systema…

2020

Publisher's version (útgefin grein)