Search results for "beta-Lactamase"

showing 10 items of 81 documents

Characterization of Acinetobacter baumannii from intensive care units and home care patients in Palermo, Italy.

2011

AbstractIn this study 45 isolates of Acinetobacter baumannii identified from patients in intensive care units of three different hospitals and from pressure ulcers in home care patients in Palermo, Italy, during a 3-month period in 2010, were characterized. All isolates were resistant to at least three classes of antibiotics, but susceptible to colistin and tygecycline. Forty isolates were non-susceptible to carbapenems. Eighteen and two isolates, respectively, carried the blaOXA-23-like and the blaOXA-58-like genes. One strain carried the VIM-4 gene. Six major rep-PCR subtype clusters were defined, including isolates from different hospitals or home care patients. The sequence type/pulsed …

Microbiology (medical)Acinetobacter baumanniimedicine.medical_specialtyPediatricsSettore MED/07 - Microbiologia E Microbiologia ClinicaGenotypeDrug resistanceMicrobial Sensitivity Testshome care patientsintensive care unitbeta-Lactamaseslaw.inventionlawmultidrug resistanceIntensive careInternal medicineDrug Resistance Multiple BacterialGenotypepolycyclic compoundsmedicinePulsed-field gel electrophoresisCluster AnalysisHumansCross Infectionbiologybusiness.industryGeneral Medicinebiochemical phenomena metabolism and nutritionbacterial infections and mycosesbiology.organism_classificationIntensive care unitHome Care ServicesAcinetobacter baumanniiAnti-Bacterial AgentsElectrophoresis Gel Pulsed-FieldCommunity-Acquired InfectionsMolecular TypingIntensive Care UnitsInfectious DiseasesItalyColistinMultilocus sequence typingepidemiologybusinesshome caremedicine.drugAcinetobacter InfectionsMultilocus Sequence Typing
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Outbreak of infection with Klebsiella pneumoniae sequence type 258 producing Klebsiella pneumoniae Carbapenemase 3 in an intensive care unit in Italy

2010

Gram-negative pathogens producing carbapenemases represent an alarming clinical threat with serious effects on patient outcomes ([3][1], [7][2]). In 2001, Yigit et al. ([11][3]) reported a novel β-lactamase termed “ K lebsiella pneumoniae carbapenemase” (KPC-1) in North Carolina. KPC-producing

Microbiology (medical)AdultMaleSettore MED/07 - Microbiologia E Microbiologia ClinicaAdolescentGenotypeKlebsiella pneumoniaemedicine.medical_treatmentTreatment outcomeMicrobial Sensitivity TestsKlebsiella pneumoniae carbapenem UTI outbreakbeta-Lactamaseslaw.inventionDisease courseMicrobiologyDisease OutbreaksBacterial proteinBacterial Proteinslawpolycyclic compoundsMedicineHumansLetters to the EditorAgedAged 80 and overbiologybusiness.industryOutbreakKlebsiella infectionsSequence Analysis DNAMiddle Agedbacterial infections and mycosesbiology.organism_classificationIntensive care unitDNA FingerprintingAnti-Bacterial AgentsBacterial Typing TechniquesKlebsiella InfectionsIntensive Care UnitsKlebsiella pneumoniaeTreatment OutcomeItalyBeta-lactamaseFemalebusiness
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Ceftazidime-avibactam use for klebsiella pneumoniae carbapenemase-producing k. pneumoniae infections: A retrospective observational multicenter study

2021

Abstract Background A growing body of observational evidence supports the value of ceftazidime-avibactam (CAZ-AVI) in managing infections caused by carbapenem-resistant Enterobacteriaceae. Methods We retrospectively analyzed observational data on use and outcomes of CAZ-AVI therapy for infections caused by Klebsiella pneumoniae carbapenemase–producing K. pneumoniae (KPC-Kp) strains. Multivariate regression analysis was used to identify variables independently associated with 30-day mortality. Results were adjusted for propensity score for receipt of CAZ-AVI combination regimens versus CAZ-AVI monotherapy. Results The cohort comprised 577 adults with bloodstream infections (n = 391) or nonba…

Microbiology (medical)Adultmedicine.medical_specialtyAzabicyclo CompoundcarbapenemasesBacterial ProteinMicrobial Sensitivity TestsNeutropeniaCeftazidimebeta-Lactamasesbeta-LactamaseCarbapenemasecarbapenemaseBacterial ProteinsRetrospective StudieLower respiratory tract infectionInternal medicineDrug CombinationAnti-Bacterial AgentmedicineHumansKPC-producing Klebsiella pneumoniaeRetrospective StudiesSeptic shockbusiness.industryCeftazidime-avibactamMicrobial Sensitivity Testceftazidime-avibactamMortality rateCarbapenemases; Ceftazidime-avibactam; KPC-producing Klebsiella pneumoniae; Adult; Anti-Bacterial Agents; Azabicyclo Compounds; Bacterial Proteins; Ceftazidime; Drug Combinations; Humans; Microbial Sensitivity Tests; Retrospective Studies; beta-Lactamases; Klebsiella Infections; Klebsiella pneumoniaeKPC-producing Klebsiella pneumoniae; carbapenemases; ceftazidime-avibactammedicine.diseaseCeftazidime/avibactamSettore MED/17KPC-producing Klebsiella pneumoniae; carbapenemases; ceftazidime-avibactam; Adult; Anti-Bacterial Agents; Azabicyclo Compounds; Bacterial Proteins; Ceftazidime; Drug Combinations; Humans; Microbial Sensitivity Tests; Retrospective Studies; beta-Lactamases; Klebsiella Infections; Klebsiella pneumoniaeAnti-Bacterial AgentsKlebsiella InfectionsDrug CombinationsKlebsiella pneumoniaeInfectious DiseasesCohortPropensity score matchingObservational studybusinessAzabicyclo Compoundsmedicine.drugHumanKlebsiella Infection
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Is the monoclonal spread of the ST258, KPC-3-producing clone being replaced in southern Italy by the dissemination of multiple clones of carbapenem-n…

2015

D. M. Geraci, C. Bonura, M. Giuffre, L. Saporito, G. Graziano, A. Aleo, T. Fasciana, F. Di Bernardo, T. Stampone, D. M. Palma and C. Mammina 1) Department of Sciences for Health Promotion and Mother-Child Care ‘G. D’Alessandro’, University of Palermo, 2) Postgraduate Specialty School in Hygiene and Preventive Medicine, University of Palermo, 3) Laboratory of Microbiology, General Hospital ARNAS ‘Civico, Di Cristina & Benfratelli’, 4) Laboratory of Microbiology, General Hospital Azienda Ospedaliera ‘Villa Sofia-V, Cervello’ and 5) II Intensive Care Unit, General Hospital ARNAS ‘Civico, Di Cristina & Benfratelli’, Palermo, Italy

Microbiology (medical)CarbapenemSettore MED/07 - Microbiologia E Microbiologia ClinicaKlebsiella pneumoniaeKPC Klebsiella pneumoniae epidemiology multidrug resistanceSettore MED/42 - Igiene Generale E Applicatabeta-Lactam Resistancebeta-LactamasesMicrobiologySettore MED/38 - Pediatria Generale E SpecialisticaBacterial ProteinsMedicineHumansGeneral hospitalbiologybusiness.industryGeneral Medicinebiology.organism_classificationKlebsiella InfectionsKlebsiella pneumoniaeInfectious DiseasesCarbapenemsItalybusinessHumanitiesmedicine.drugClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
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New β-Lactam-β-Lactamase Inhibitor Combinations.

2020

The limited armamentarium against drug-resistant Gram-negative bacilli has led to the development of several novel β-lactam-β-lactamase inhibitor combinations (BLBLIs). In this review, we summarize their spectrum of in vitro activities, mechanisms of resistance, and pharmacokinetic-pharmacodynamic (PK-PD) characteristics. A summary of available clinical data is provided per drug. Four approved BLBLIs are discussed in detail. All are options for treating multidrug-resistant (MDR) Enterobacterales and Pseudomonas aeruginosa Ceftazidime-avibactam is a potential drug for treating Enterobacterales producing extended-spectrum β-lactamase (ESBL), Klebsiella pneumoniae carbapenemase (KPC), AmpC, an…

Microbiology (medical)DrugImipenemBacilliEpidemiologyKlebsiella pneumoniaemedia_common.quotation_subjectMicrobial Sensitivity Testsmedicine.disease_causebeta-LactamsMeropenemMicrobiologyDrug Resistance Multiple BacterialGram-Negative Bacteriapolycyclic compoundsmedicinemedia_commonGeneral Immunology and MicrobiologybiologyPseudomonas aeruginosabusiness.industryPublic Health Environmental and Occupational Healthbiochemical phenomena metabolism and nutritionbacterial infections and mycosesbiology.organism_classificationCeftazidime/avibactamAcinetobacter baumanniiDrug CombinationsInfectious DiseasesbacteriaErratumbusinessbeta-Lactamase Inhibitorsmedicine.drugClinical microbiology reviews
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Influence of Haemophilus influenzae β-lactamase production and/or ftsI gene mutations on in vitro activity of and susceptibility rates to aminopenici…

2007

Microbiology (medical)Haemophilus InfectionsPenicillin binding proteinsmedicine.drug_classCephalosporinMicrobial Sensitivity TestsGene mutationmedicine.disease_causebeta-LactamasesMicrobiologyHaemophilus influenzaeAmp resistanceAmpicillinmedicineHumansPenicillin-Binding ProteinsPharmacology (medical)Mutationbusiness.industryGeneral MedicineHaemophilus influenzaeIn vitroCephalosporinsPhenotypeInfectious DiseasesSpainMutationAmpicillinbusinessAmpicillin Resistancemedicine.drugInternational Journal of Antimicrobial Agents
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Multidrug and broad-spectrum cephalosporin resistance among Salmonella enterica serotype enteritidis clinical isolates in southern Italy.

2002

ABSTRACT From 1992 to 1997, only six sporadic isolates of Salmonella enterica serotype Enteritidis from patients with cases of gastroenteritis in southern Italy exhibited resistance to broad-spectrum cephalosporins. Five isolates produced SHV-12, and one isolate encoded a class C β-lactamase. The bla SHV-12 gene was located in at least two different self-transferable plasmids, one of which also carried a novel class 1 integron.

Microbiology (medical)Serotypemedicine.drug_classEpidemiologySalmonella enteritidisCephalosporinIntegronbeta-LactamasesMicrobiologyPlasmidDrug Resistance Multiple BacterialGenotypemedicineHumansamoxicillin plus clavulanic acid; ampicillin; antibiotic agent; aztreonam; beta lactamase; cefotaxime; cefoxitin; ceftazidime; cephalosporin derivative; chloramphenicol; kanamycin; plasmid DNA; streptomycin; sulfonamide; tobramycin antibiotic resistance; article; bacterial infection; bacterium isolate; DNA probe; gastroenteritis; gastrointestinal infection; Italy; nonhuman; nucleotide sequence; phenotype; plasmid; priority journal; Salmonella; Salmonella enterica Base Sequence; beta-Lactamases; Cephalosporin Resistance; Cross Infection; Drug Resistance Multiple Bacterial; Gastroenteritis; Genes Bacterial; Humans; Italy; Plasmids; Salmonella enteritidis; Salmonella Infections Bacteria (microorganisms); Negibacteria; Salmonella; Salmonella entericaCephalosporin ResistanceCross InfectionbiologyBase SequenceCephalosporin Resistancebiochemical phenomena metabolism and nutritionbacterial infections and mycosesbiology.organism_classificationVirologyGastroenteritisItalySalmonella enteritidisSalmonella entericaGenes BacterialSalmonella Infectionsbiology.proteinPlasmidsJournal of clinical microbiology
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Multiclonal emergence of carbapenem-resistant Klebsiella pneumoniae in Tuscany, Italy

2010

Microbiology (medical)Settore MED/07 - Microbiologia E Microbiologia ClinicaImipenemGenotypemedicine.drug_classCarbapenem resistant Klebsiella pneumoniaemedicine.medical_treatmentAntibioticsMicrobial Sensitivity TestsBiologySettore MED/42 - Igiene Generale E ApplicataMeropenembeta-Lactam Resistancebeta-LactamasesMicrobiologychemistry.chemical_compoundmedicineHumansPharmacology (medical)Molecular EpidemiologyKlebsiella pneumoniae resistenza ai carbapenemi multiclonaleGeneral MedicineDNA FingerprintingAnti-Bacterial AgentsBacterial Typing TechniquesElectrophoresis Gel Pulsed-FieldKlebsiella InfectionsMultiple drug resistanceKlebsiella pneumoniaePhenotypeInfectious DiseasesCarbapenemsItalychemistryBeta-lactamaseErtapenemmedicine.drugBeta lactam antibioticsInternational Journal of Antimicrobial Agents
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Populations of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae are different in human-polluted environment and foo…

2021

Abstract Objectives To assess the extent to which food items are a source of extended-spectrum β-lactamase (ESBL) -producing Escherichia coli (ESBL-Ec) and ESBL-producing Klebsiella pneumoniae (ESBL-Kp) for humans in five European cities. Methods We sampled 122 human polluted (hp)-environments (sewers and polluted rivers, as a proxy of human contamination) and 714 food items in Besancon (France), Geneva (Switzerland), Sevilla (Spain), Tubingen (Germany) and Utrecht (The Netherlands). A total of 254 ESBL-Ec and 39 ESBL-Kp isolates were cultured. All genomes were fully sequenced to compare their sequence types (ST) and core genomes, along with the distribution of blaESBL genes and their genet…

Microbiology (medical)Veterinary medicineKlebsiella pneumoniaeEscherichia coli K. pneumoniae ESBL food environmentBiologyEnvironmentPolluted environmentmedicine.disease_causebeta-LactamasesK. pneumoniae03 medical and health sciencesFood chainPlasmidData sequencesExtended-spectrum β-lactamasemedicinepolycyclic compoundsEscherichia coliHumansEscherichia coliEscherichia coli Infections030304 developmental biologyddc:6160303 health sciences030306 microbiologyK pneumoniaeGeneral MedicineSequence typesbiochemical phenomena metabolism and nutritionbiology.organism_classificationbacterial infections and mycoses3. Good healthAnti-Bacterial AgentsKlebsiella InfectionsKlebsiella pneumoniaeInfectious Diseases[SDV.MP]Life Sciences [q-bio]/Microbiology and ParasitologyESBLFoodbacteria[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyPlasmids
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Occurrence of CTX-M Producing Escherichia coli in Soils, Cattle, and Farm Environment in France (Burgundy Region).

2012

Article en open access; International audience; CTX-M [a major type of extended-spectrum beta-lactamase (ESBU] producing Escherichia coli are increasingly involved in human infections worldwide. The aim of this study was to investigate potential reservoirs for such strains: soils, cattle, and farm environment. The prevalence of bla(CTX-M) genes was determined directly from soil DNA extracts obtained from 120 sites in Burgundy (France) using real-time PCR. bla(CTX-M) targets were found in 20% of the DNA extracts tested. Samples of cattle feces (n = 271) were collected from 182 farms in Burgundy. Thirteen ESBL-producing isolates were obtained from 12 farms and further characterized for the pr…

Microbiology (medical)Veterinary medicinesolBiodiversité et Ecologie[SDE.MCG]Environmental Sciences/Global ChangesPEDOLOGIElcsh:QR1-502extended-spectrum beta-lactamasefarm environmentbourgogneBiologymedicine.disease_causePastureMicrobiologyextended spectrum beta-lactamaselcsh:MicrobiologyMicrobiologysoilBiodiversity and Ecology03 medical and health sciencesbiologie du solGenotypeLong term survivalmedicineEscherichia coliCTX-MMilieux et Changements globauxEscherichia coliFeces030304 developmental biologyOriginal Researchbactérie2. Zero hunger0303 health sciencesgeographygeography.geographical_feature_category030306 microbiologyadnSoil dnabiochemical phenomena metabolism and nutritionbacterial infections and mycosesManureextended-spectrumbeta-lactamasecattlePEDOLOGIE;extended-spectrumbeta-lactamaseSoil water[SDE.BE]Environmental Sciences/Biodiversity and EcologyBurgundyFrontiers in microbiology
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