Search results for "binder"
showing 10 items of 44 documents
Tyre rubber-modified bitumens development: the effect of varying processing conditions
2013
Tyre rubber-modified binders (TR-MBs), produced through McDonald’s wet process and used worldwide (e.g. asphalt rubber), have been demonstrated to provide various benefits to pavements and, moreover, they represent a good opportunity for recycling tyre rubber (TR). However, this technology is still struggling to be fully adopted in Europe, mainly because of their poor stability during high temperatures storage, which leads to high initial costs in modifying existing asphalt plants. Storage stable TR-MBs are proving to be a great option and their development could be the key to spread the recycling of TR within paving applications in Europe. This paper aims to enrich this field of research b…
Synthesis, characterization, cellular uptake and interaction with native DNA of a bis(pyridyl)-1,2,4-oxadiazole copper(II) complex
2010
The copper(II) complex of 3,5-bis(2'-pyridyl)-1,2,4-oxadiazole was synthesized and characterized. X-Ray crystallography revealed that the complex consists of a discrete [Cu(3,5-bis(2'-pyridyl)-1,2,4-oxadiazole)(2)(H(2)O)(2)](2+) cation and two ClO(4)(-) anions. The Cu(II) coordination sphere has a distorted octahedral geometry and each ligand chelates the copper ion through the N(4) nitrogen of the oxadiazole ring and the nitrogen of one pyridine moiety. The coordinated water molecules are in cis position and each of them is H-bonded to the 5-pyridyl nitrogen of the oxadiazole ligand and to an oxygen of the perchlorate anion. Biological assays showed that, despite the free ligand not being …
DNA minor groove binders: an overview on molecular modeling and QSAR approaches
2007
Molecular recognition of DNA by small molecules and proteins is a fundamental problem in structural biology and drug design. Understanding of recognition in both sequence-selective and sequence neutral ways at the level of successful prediction of binding modes and site selectivity will be instrumental for improvements in the design and synthesis of new molecules as potent and selective gene-regulatory drugs. Minor groove is the target of a large number of non-covalent binding agents. DNA binding with specific sequences, mostly AT, takes place by means of a combination of directed hydrogen bonding to base pair edges, van der Waals interactions with the minor groove walls and generalized ele…
Antiviral Mechanisms of N-Phenyl Benzamides on Coxsackie Virus A9
2023
Enteroviruses are one of the most abundant groups of viruses infecting humans, and yet there are no approved antivirals against them. To find effective antiviral compounds against enterovirus B group viruses, an in-house chemical library was screened. The most effective compounds against Coxsackieviruses B3 (CVB3) and A9 (CVA9) were CL212 and CL213, two N-phenyl benzamides. Both compounds were more effective against CVA9 and CL213 gave a better EC50 value of 1 µM with high a specificity index of 140. Both drugs were most effective when incubated directly with viruses suggesting that they mainly bound to the virions. A real-time uncoating assay showed that the compounds stabilized the virion…
Farocki e Fassbinder: l'eredità contrastata del Nuovo Cinema Tedesco
2014
Il saggio ripercorre alcune delle tappe fondamentali del cosiddetto nuovo cinema tedesco, rintracciandone le ragioni dell'origine e l'eridità
Synthesis of the new oligopeptide pyrrole derivative isonetropsin and its one pyrrole unit analogue
2013
We have designed and synthesized isonetropsin and its one pyrrole unit analogue in which the amine and carbonyl groups have been switched in positions 2 and 4, respectively instead of 4 and 2 positions of the natural antibiotic netropsin.
First tests of mechanical harvest of Origanum vulgare L.
2003
In Italy Origanum vulgare L. is cultivated only in few areas and its production does not even satisfy the national market demand. Until now the interest on this crop has been very low because of the high cost of manual harvest and bunch binding. The aim of this work is to evaluate the use of a reaper-binder (made for harvesting cereal crops) for harvesting and bunch binding Origanum vulgare L. The tests were carried out in Sicily, in the summer of 2001. The mechanical harvest was carried out using the reaper-binder unmodified, but the results were not satisfactory. The machine was then modified reducing its forward speed and cutting height, in order to improve its working productivity and h…
Comparison of Mechanical, Assisted and Manual Harvest of Origanum vulgare L.
2022
In Italy, the production of Origanum vulgare L. is lower than the national market demand, so there is an increasing interest in this crop, even if the manual harvest and bunch binding represent ca. 60% of the production cost. The aim of this work is to evaluate the harvest efficiency, as well as the working capacity, productivity and quality of mechanical harvesting by means of a reaper-binder designed for cereal and forage crops and assisted harvesting by means of a long-reach edge trimmer. In fact, the final aim is to suggest a machine and a method for oregano harvesting that could significantly reduce the time and, therefore, the cost of this crop operation, while achieving a product qua…
MADoSPRO: a new approach to molecular modelling studies on a series of DNA minor groove binders
2006
The aim of this work was devoted to develop a method to predict Delta G values for a series of minor groove binders. Starting from a matrix of docking dataset for 10 minor groove binders (known and not) to 20 DNA fragments, with various sequences, it was possible to analyze the interaction modes and to calculate the Delta G value for new derivatives through MADoSPRO procedure. The method allowed, through the QSPR analysis, to characterize the type of interactions in such complexes, that was demonstrated to be related to quantum chemical and electrostatic descriptors, in agreement with the information available in literature on the structural requirements of specific minor groove ligands. Mo…