Search results for "blas"
showing 10 items of 2217 documents
Effetti biologici del polifenoli dell'olio extravergine di oliva di cultivar nazionali su cellule tumorali umane sensibili e resistenti ai farmaci an…
2012
Controversies in ameloblastoma management: Evaluation of decision making, based on a retrospective analysis
2020
Background The ameloblastoma management is still challenging to the high recurrence rates and significant morbidity associated with radical treatment. The purpose of this 10-year retrospective study was to analyze the influence of ameloblastoma type and treatment strategy on the long-term outcomes and recurrence rates. Material and Methods The retrospective analyses of 64 histologically-confirmed ameloblastoma cases was performed. The possible risk factors for recurrence and the development of complications were estimated statistically. Results The treatment strategy applied for this group of patients was the following: thirty-four patients (53.1%) were treated conservatively with enucleati…
Les sacrifices du corps: configuration, formes et évolution de(s) mémoire(s) de Blas de Lezo en Espagne. XVIIIe-XIXe siècles
2020
Resumen Desde las aportaciones metodológicas y teóricas de los memory studies, este artículo analiza la configuración de la memoria de Blas de Lezo desde sus inicios hasta finales del siglo XIX. A partir del estudio de biografías, compendios históricos y artículos periodísticos principalmente, tratan de delimitarse los factores que confluyen en su construcción, la versatilidad de su funcionalidad política y las constantes modificaciones producidas en sus usos públicos. La revalorización de la figura de Lezo es interpretada como símbolo del imperio y la nación española, esencia de la españolidad –unida a la exaltación de los fueros y la especificidad vasca– y ejemplo de sacrificio para una m…
Molecular Mechanisms of the Blockage of Glioblastoma Motility
2021
Glioblastoma (GBM) is the most common and lethal brain tumor. GBM has a remarkable degree of motility and is able to infiltrate the healthy brain. In order to perform a rationale-based drug-repositioning study, we have used known inhibitors of two small Rho GTPases, Rac1 and Cdc42, which are upregulated in GBM and are involved in the signaling processes underlying the orchestration of the cytoskeleton and cellular motility. The selected inhibitors (R-ketorolac and ML141 for Cdc42 and R-ketorolac and EHT 1864 for Rac1) have been successfully employed to reduce the infiltration propensity of GBM in live cell imaging studies. Complementarily, all-atom simulations have elucidated the molecular …
Antitumor Effect of Cabozantinib in Bone Metastatic Models of Renal Cell Carcinoma
2021
Background: The presence of bone metastases in renal cell carcinoma (RCC) negatively affects patients’ survival. Data from clinical trials has highlighted a significant benefit of cabozantinib in bone metastatic RCC patients. Here, we evaluated the antitumor effect of cabozantinib in coculture models of renal cell carcinoma (RCC) and osteoblasts (OBs) to investigate whether and how its antiproliferative activity is influenced by OBs. Methods: Bone/RCC models were generated, coculturing green fluorescent protein (GFP)-tagged Caki-1 and 786-O cells with human primary OBs in a “cell–cell contact” system. RCC proliferation and the OB molecular profile were evaluated after the cabozantinib treat…
García, Vicente Blas
2012
Entrada de Vicente Blas García en el Diccionario Biográfico y Bibliográfico del Humanismo español (siglos XV-XVII). Este humanista valenciano sucedió a su maestro Palmireno en la cátedra de retórica de la Universidad de Valencia. Entry of Vicente Blas García in the Biographical and Bibliographical Dictionary of Spanish Humanism (15th-17th centuries). This valencian humanist succedeed to his master Palmireno in the Chair in Rhetoric at the University of Valencia.
1988 12. 30 de diciembre de 1988. Dimite Ricard Pérez Casado, alcalde de Valencia
2014
1988 12. 30 de diciembre de 1988. Dimite Ricard Pérez Casado, alcalde de Valencia. Tras más de nueve años como alcalde de Valencia (1979-1988) la prensa local recogía en portada la dimisión de Ricard Pérez Casado como alcalde de Valencia, al que acompañaba su número dos, Fernando Puente Roig. Tres años después, el IV congreso del PSPV -Alicante 1985- le pasaba factura, por haber sido elegido secretario general de la ciudad de Valencia, frente a la lista de Joan Lerma. Con su dimisión desaparecía otro de los que se habían identificado con la renovación del partido. Pérez Casado es uno de los pocos políticos valencianos que ha publicado sus memorias políticas en primera persona: "Viaje de ida…
Photoluminescent Detection of Human T-Lymphoblastic Cells by ZnO Nanorods.
2020
The precise detection of cancer cells currently remains a global challenge. One-dimensional (1D) semiconductor nanostructures (e.g., ZnO nanorods) have attracted attention due to their potential use in cancer biosensors. In the current study, it was demonstrated that the possibility of a photoluminescent detection of human leukemic T-cells by using a zinc oxide nanorods (ZnO NRs) platform. Monoclonal antibodies (MABs) anti-CD5 against a cluster of differentiation (CD) proteins on the pathologic cell surface have been used as a bioselective layer on the ZnO surface. The optimal concentration of the protein anti-CD5 to form an effective bioselective layer on the ZnO NRs surface was selected. …
Una piazza lineare ai margini del parco
2013
Attorno all’area archeologica di Agrigento si è sviluppata, infatti, una complessa città frammentata e abusiva, totalmente avvolta da infrastrutture di trasporto sovrabbondanti. Tra questi frammenti, Villaggio Mosè - vivace realtà commerciale sviluppatasi “spontaneamente” lungo una Strada Statale - costituisce un fenomeno paradossale in quanto “organizzata” per soddisfare le esigenze di chi si sposta utilizzando l’automobile e non garantisce chi vuole esercitare il “diritto di muoversi liberamente” (Cecchini, Talu, 2011). Il contesto richiede interventi risolutivi nell’intento di migliorare la “qualità della vita nelle città” (UE, Comunicazione n.60, 2004, 29). Questa dipende, infatti, fort…
C8161-melanoomasolulinjan erittämien tekijöiden vaikutus fibroblastien hyaluronaanituotantoon
2011
Hyaluronaani on suurikokoinen soluväliaineen sokerirakenne. Se koostuu toistuvista sokerimolekyyleistä N- asetyyliglukosaminista ja glukuronihaposta. Hyaluronaani syntetisoidaan solukalvolla hyaluronaani- syntaasien (HAS) toimesta, joita nisäkkäillä on kolme isomuotoa (HAS1-3). Hyaluronaanin hajotus tapahtuu hyaluronidaasientsyymien (Hyal) toimesta. Hyaluronaanin pääasiallinen solukalvoreseptori on CD44, jonka avulla hyaluronaaniketjut ovat sitoutuneet solukalvoon. Hyaluronaania esiintyy runsaasti etenkin sidekudoksessa ja kerrostuneessa epiteelissä kuten ihossa. Hyaluronaanin määrän on havaittu lisääntyneen syövissä ja tämä korreloi useasti potilaan huonon ennusteen kanssa. Hyaluronaanin l…