Search results for "block"

Proof of Concept of Therapeutic Gene Modulation of MBNL1/2 in Myotonic Dystrophy

2022

La distrofia miotónica tipo 1 es una enfermedad genética rara multisistémica que afecta a 1 de cada 3000-8000 personas. La causa molecular de la enfermedad proviene de repeticiones tóxicas “CTG” en el gen DMPK (DM Protein Kinase). Tras la transcripción, estas repeticiones forman una estructura de horquilla que se une con alta afinidad a la familia de proteínas MBNL (Muscleblind-like) que agota su función de regulación de la poliadenilación y el splicing alternativo postranscripcional en numerosos transcritos. La pérdida de función de MBNL provoca una cascada de efectos posteriores, que eventualmente conducen a síntomas clínicos que incluyen miotonía, debilidad y atrofia muscular, cataratas,…

Rain on building façades

2006

Rain is one of the main causes of moisture damage to the building envelope, leading to problems such as rain penetration, frost and salt damage, discoloration by leaching, soiling by differential washing, etc. The potential of deterioration due to rain depends on the façade material, the junction of building envelope components, the overall geometry of the building, but also the presence or absence of modulation on the façade. In this paper, Computational fluid dynamics (CFD) simulations are used to analyze these effects and illustrated with examples taken in Sicily. It is firstly shown that buildings protect themselves from driving rain due to the wind blocking effect, but that façade open…

Multiple factor analysis: principal component analysis for multitable and multiblock data sets

2013

Enhancing the Activation and Releasing the Brakes: A Double Hit Strategy to Improve NK Cell Cytotoxicity Against Multiple Myeloma

2018

Natural killer (NK) cells are innate lymphocytes with a strong antitumor ability. In tumor patients, such as multiple myeloma (MM) patients, an elevated number of NK cells after stem cell transplantation (SCT) has been reported to be correlated with a higher overall survival rate. With the aim of improving NK cell use for adoptive cell therapy, we also addressed the cytotoxicity of patient-derived, cytokine-stimulated NK cells against MM cells at specific time points: at diagnosis and before and after autologous stem cell transplantation. Remarkably, after cytokine stimulation, the patients' NK cells did not significantly differ from those of healthy donors. In a small cohort of MM patients…

FRI0150 Mtor blockade by rapamycin decreases arthritis and spondylitis development and severity in hla-b27 transgenic rats

2018

Career situation of first and presenting author Student for a master or a PhD. Introduction TNF and IL-17A have been demonstrated as key inflammatory cytokines in Spondyloarthritis (SpA), whereas targeting bone remodeling remains an unmet clinical need in SpA. The mammalian target of rapamycin (mTOR) regulates IL-17 expression and osteogenesis and could therefore be a promising therapeutic target in SpA. Objectives To investigate if blockade of mTOR with rapamycin inhibits the pathological processes in inflammation and bone in SpA. Methods Cytokines were measured by ELISA in the supernatant from SpA patient PBMCs stimulated with anti-CD3/CD28, with various concentrations of rapamycin. SpA F…

Museums as participants in the market game: The political and economic context of the functioning of the museums

2017

Under the influence of contemporary social and political changes, which have resulted in, inter alia, changes in the structure of museum audiences and their expectations, museums have had to implement new practices and tools which were previously not present in their fields of interest. these processes changed the definition of the mission of a contemporary museum and the way of ommunicating with participants of culture. today a museum, like every other institution on the entertainment and leisure market, has to attract recipients of its offer. Museums thus engage in ever more close relationships with the field of economy. Moreover, the model of public financing of culture subjects the acti…

Stymulacja pęczka Hisa u osoby starszej z proksymalnym blokiem przedsionkowo-komorowym po zawale mięśnia sercowego

2018

Stymulacja pęczka Hisa (HBP) umożliwia synchronizację przedsionkowo-komorową i międzykomorową. W opisanym przypadku zwrócono uwagę na związek między poziomem bloku, synchronią komorową oraz funkcją rozkurczową u chorego z umiarkowaną dysfunkcją skurczową lewej komory świeżo po zawale serca. HBP jest korzystna w leczeniu zaburzeń przewodzenia i zapobieganiu dalszym zaburzeniom funkcji skurczowej i rozkurczowej. W artykule przedstawiono przypadek 92-letniego mężczyzny w bardzo dobrym stanie psychofizycznym z napadowym blokiem przedsionkowo-komorowym II stopnia i utrwalonym długim odstępem PR w przebiegu zawału mięśnia sercowego bez uniesienia odcinka ST-T, leczonego angioplastyką gałęzi okala…

Supramolecular Modification of ABC Triblock Terpolymers in Confinement Assembly

2018

The self-assembly of AB diblock copolymers in three-dimensional (3D) soft confinement of nanoemulsions has recently become an attractive bottom up route to prepare colloids with controlled inner morphologies. In that regard, ABC triblock terpolymers show a more complex morphological behavior and could thus give access to extensive libraries of multicompartment microparticles. However, knowledge about their self-assembly in confinement is very limited thus far. Here, we investigated the confinement assembly of polystyrene-block-poly(4-vinylpyridine)-block-poly(tert-butyl methacrylate) (PS-b-P4VP-b-PT or SVT) triblock terpolymers in nanoemulsion droplets. Depending on the block weight fractio…

Blocks to, and building blocks of, narrativity : fragments, anecdotes, and narrative lines in David Markson’s Reader’s block

2017

David Markson’s Reader’s block (1996) consists of 193 pages of quotations, anecdotes, names, and fragments. The book bears the paratext “A novel,” and the work has indeed been read as a narrative whole, in which “an aging author [...] contemplates the writing of a novel.” By being out of ordinary and therefore worth of telling, the anecdotes or curiosities seemingly fulfill the requirements of a “natural” narrative as defined by Monika Fludernik (1996). However, a mass of such mini-narratives, mixed with even more fragmentary texts, seems to defy narrativity (and tellability). In my reading, the ostensive block to narrativity also functions as its very building block. Thanks to polysemy, bl…

Darbu plānošanas optimizācijas problēmu risināšana ar binārās programmēšanas metodēm

2016

Darbā aprakstītas trīs dažādas flow shop problēmas ar uzdevumu minimizēt kopējo darbu izpildes laiku: permutation flow shop problēma, blocking flow shop problēma un no-wait flow shop problēma. Katrai no problēmām ir atrasts atbilstošais lineārās programmēšanas uzdevums ar veseliem un bināriem mainīgajiem. Problēmu risināšanai ir aprobētas divas klasiskās metodes, ko izmando diskrētās programmēšanas uzdevumiem: Gomorī apgriešanas metode un sazarošanās un robežu algoritms. Skaitliskie aprēķini tika veikti, izmantojot datorprogrammu LPSolve IDE.