Search results for "bone"
showing 10 items of 2629 documents
Focused Ultrasound Effects on Osteosarcoma Cell Lines
2019
MRI guided Focused Ultrasound (MRgFUS) has shown to be effective therapeutic modality for non-invasive clinical interventions in ablating of uterine fibroids, in bone metastasis palliative treatments, and in breast, liver, and prostate cancer ablation. MRgFUS combines high intensity focused ultrasound (HIFU) with MRI images for treatment planning and real time thermometry monitoring, thus enabling non-invasive ablation of tumor tissue. Although in the literature there are several studies on the Ultrasound (US) effects on cell in culture, there is no systematic evidence of the biological effect of Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) treatment on osteosarcoma cells, …
In vitro assessment of a novel additive manufactured titanium implant abutment
2021
Background Dental implant temporization remains a clinical challenge. A novel abutment simplifying the procedure was developed, but conventional fabrication was costly and unpredictable. A workflow was developed to fabricate the novel abutment using additive manufacturing. This in vitro investigation assessed the additive manufactured (AM) novel abutments to conventionally manufactured (CM) abutments. Material and methods The AM abutments were fabricated in dental-grade titanium (Ti-6Al-4V) using Selective Laser Melting and were post-processed. The CM abutments were milled and subsequently laser welded manually. Pin strength of the abutments was assessed using a universal loading machine. T…
Effects of Interobserver Variability on 2D and 3D CT- and MRI-Based Texture Feature Reproducibility of Cartilaginous Bone Tumors
2021
AbstractThis study aims to investigate the influence of interobserver manual segmentation variability on the reproducibility of 2D and 3D unenhanced computed tomography (CT)- and magnetic resonance imaging (MRI)-based texture analysis. Thirty patients with cartilaginous bone tumors (10 enchondromas, 10 atypical cartilaginous tumors, 10 chondrosarcomas) were retrospectively included. Three radiologists independently performed manual contour-focused segmentation on unenhanced CT and T1-weighted and T2-weighted MRI by drawing both a 2D region of interest (ROI) on the slice showing the largest tumor area and a 3D ROI including the whole tumor volume. Additionally, a marginal erosion was applied…
Calcium sulfate and PTFE nonporous barrier for regeneration of experimental bone defects
2008
Made available in DSpace on 2022-04-28T18:55:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-06-01 The aim of the study was to evaluate the possibility to obtain guided bone regeneration with two types of physical barriers (calcium sulfate and PTFE nonporous barrier) in surgical defects created in rat parietal bones. In the right parietal bone the calcium sulfate barrier filled out the whole defect and in the left parietal bone the barrier of PTFE was positioned in the floor and externally to the surgical defect. After 7, 14, 30 and 45 days four animals were sacrificed in each period and the bone containing the defects were submitted to the microscopic analysis. The results of the…
Propriétés et performances de phosphines ferrocéniques dans le couplage C-O, C-S et C-N : nouvelles méthodologies de synthèse au palladium
2012
Multidentate ligands usually show great activities in low loading organometallic catalysis in palladium. Among these ligands, the use of ferrocenyl polyphosphane ligands give interesting results. Robust palladium-ferrocenyl triphosphane catalytic systems have permitted to obtain biarylamines and aryl-heteroaryl ethers in the presence of low catalytic loadings. DFT studies on catalytic cycle during formation of aryl-heteroaryl ethers were carried out. The presence of third phosphino group stabilizes a transition state which enhances the rate of the reductive elimination. Triarylamines were obtained with ferrocenyl diphosphane in the presence of 2 mol% of palladium loading. Moderate to excell…
Effects of physical activity on the lean and fat mass of the legs and on the femoral BMD in young adults
2010
Aim. To evaluate the effects of physical activity on the lean (LLM) and fat (FLM) mass of both legs and on the left femur neck bone mineral density (FemBMD) in young adults. Methods. Subjects were 48 healthy male, mean age 25 (range 20-32). Subjects were assigned to one of three groups according to the physical activity practiced from age 10 onwards: 17 sedentary subjects (A), 15 active subjects (B) and 16 athletes (C). LLM and FLM (g) were evaluated by Dual Energy X-ray Absorptiometry (DEXA), as well as FemBMD (g/cm2). The data is shown as mean values ± standard deviation. For the statistical analysis of the data, linear regression analysis and Student's t test for unpaired data were used.…
Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin GTPase 3.
2014
Many neurodegenerative disorders present with sensory loss. In the group of hereditary sensory and autonomic neuropathies loss of nociception is one of the disease hallmarks. To determine underlying factors of sensory neurodegeneration we performed whole-exome sequencing in affected individuals with the disorder. In a family with sensory neuropathy with loss of pain perception and destruction of the pedal skeleton we report a missense mutation in a highly conserved amino acid residue of atlastin GTPase 3 (ATL3), an endoplasmic reticulum-shaping GTPase. The same mutation (p.Tyr192Cys) was identified in a second family with similar clinical outcome by screening a large cohort of 115 patients …
Neurophysiological changes associated with implant-associated augmentation procedures in the lower jaw
2017
Background Neurophysiological changes after oral and maxillofacial surgery remain one of the topics of current research. Purpose This study evaluated if implant placement associated with augmentation procedures increases the possibility of sensory disturbances or result in impaired quality of life during the healing period. Material and Methods Patients who had obtained an implant placement in the lower jaw in combination with augmentation procedures were examined by implementing a comprehensive Quantitative Sensory Testing (QST) protocol for extra- and intraoral use. As augmentation procedures, we used Guided Bone Regeneration (Group A) and Customized Bone Regeneration (Group B) techniques…
PHENOTYPIC PROFILING OF OSTEOTROPIC BREAST CANCER CELLS
2015
One of the preferred locations of metastases from breast cancer is the bone tissue. On the other hand, it should be recalled that mammary tumors with equal clinical diagnosis have a different course, and also different metastatic progression. Therefore, it would be helpful to have appropriate markers of osteotropism to test on the surgical cancer tissues, in order to predict the possible propensity of the breast cancer to generate bone metastases and to adequate the therapeutic plan. We previously reported1,2 on the setting-up of an in vitro model for the study of the osteotropic propensity of breast cancer cells and the influences exerted by the bone microenvironment on the cancer cells ph…
Construction of Disjoint Virtual Backbones for Wireless Sensor Networks
2020
A wireless sensor network is a wireless network of sensors aimed at monitoring physical events. It has ingratiated itself into almost all areas of human endeavors. Data dissemination in these networks is quite challenging and is generally accomplished by flooding. But flooding introduces broadcast storm problem due from implosion and overlap. To overcome this, topology management can prescribe a virtual backbone network to which routing is confined. In this paper we propose an algorithm that constructs multiple disjoint virtual backbone networks, using only nodes' locations. The disjointedness makes routing more robust and the network exploitation energy efficient. Simulations show our algo…