Search results for "bp"
showing 10 items of 672 documents
Metabolic syndrome enhances endoplasmic reticulum, oxidative stress and leukocyte–endothelium interactions in PCOS
2017
Polycystic ovary syndrome (PCOS) is associated with insulin resistance, which can lead to metabolic syndrome (MetS). Oxidative stress and leukocyte-endothelium interactions are related to PCOS. Our aim was to evaluate whether the presence of MetS in PCOS patients can influence endoplasmic reticulum (ER) and oxidative stress and leukocyte-endothelium interactions.This was a prospective controlled study conducted in an academic medical center. The study population consisted of 148 PCOS women (116 without/32 with MetS) and 112 control subjects (87 without / 25 with MetS). Metabolic parameters, reactive oxygen species (ROS) production, ER stress markers (GRP78, sXBP1, ATF6), leukocyte-endotheli…
Role of T-Cell Polarization and Inflammation and Their Modulation by n-3 Fatty Acids in Gestational Diabetes and Macrosomia.
2015
Th (T helper) cells are differentiated into either Th1 or Th2 phenotype. It is generally considered that Th1 phenotype is proinflammatory, whereas Th2 phenotype exerts anti-inflammatory or protective effects. Gestational diabetes mellitus (GDM) has been associated with a decreased Th1 phenotype, whereas macrosomia is marked with high expression of Th1 cytokines. Besides, these two pathological situations are marked with high concentrations of inflammatory mediators like tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6), known to play a pivotal role in insulin resistance. Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert a beneficial effect by shifting Th1/Th2 balance to a …
Srebf2 Locus Overexpression Reduces Body Weight, Total Cholesterol and Glucose Levels in Mice Fed with Two Different Diets
2020
Macronutrients represent risk factors for hyperlipidemia or diabetes. Lipid alterations and type 2 diabetes mellitus are global health problems. Overexpression of sterol regulatory element-binding factor (Srebf2) in transgenic animals is linked to elevated cholesterol levels and diabetes development. We investigated the impact of increased Srebf2 locus expression and the effects of control and high-fat, high-sucrose (HFHS) diets on body weight, glucose and lipid metabolisms in transgenic mice (S-mice). Wild type (WT) and S-mice were fed with both diets for 16 weeks. Plasma glucose, insulin and lipids were assessed (n = 25). Immunostainings were performed in liver, pancreas and fat (N = 10).…
EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research
2017
We argue that the field of extracellular vesicle (EV) biology needs more transparent reporting to facilitate interpretation and replication of experiments. To achieve this, we describe EV-TRACK, a crowdsourcing knowledgebase (http://evtrack.org) that centralizes EV biology and methodology with the goal of stimulating authors, reviewers, editors and funders to put experimental guidelines into practice.
Modulation of Neocortical Development by Early Neuronal Activity: Physiology and Pathophysiology.
2017
Animal and human studies revealed that patterned neuronal activity is an inherent feature of developing nervous systems. This review summarizes our current knowledge about the mechanisms generating early electrical activity patterns and their impact on structural and functional development of the cerebral cortex. All neocortical areas display distinct spontaneous and sensory-driven neuronal activity patterns already at early phases of development. At embryonic stages, intermittent spontaneous activity is synchronized within small neuronal networks, becoming more complex with further development. This transition is accompanied by a gradual shift from electrical to chemical synaptic transmiss…
Graphic emotion: a critical rhetorical analysis of online children-related charity communication in poland
2019
This study explores dominant applications of graphic affordances in a sample of children-related charity appeals collected from the official websites of nine prominent Polish foundations in late 2016. It provides a systematic description of salient typographic and iconographic resources and an assessment of their rhetorical potential to solicit donations. The analysis focuses on three dominant discursive strategies used by charity communicators, namely how graphic affordances project utility (logos), confidence (ethos) and engagement (pathos). The article offers a critique of strategic emotional stimulation through aestheticized imagery and infantilizing graphics that replace arguments with…
"Table 14" of "Global baryon number conservation encoded in net-proton fluctuations measured in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV"
2020
HIJING results.
"Table 13" of "Global baryon number conservation encoded in net-proton fluctuations measured in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV"
2020
Local baryon number conservation, deltaY_corr = 2.
"Table 11" of "Global baryon number conservation encoded in net-proton fluctuations measured in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV"
2020
Global baryon number conservation.
"Table 12" of "Global baryon number conservation encoded in net-proton fluctuations measured in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV"
2020
Local baryon number conservation, deltaY_corr = 5.