Search results for "brain development"
showing 4 items of 24 documents
Involvement of Thyroid Hormones in Brain Development and Cancer
2021
Simple Summary Development and function of the mammalian brain clearly require precise regulation of gene expression at both the transcriptional and post-transcriptional level. Thyroid hormones have been recognized to play a fundamental role in these processes, by acting at multiple levels and in different brain cell types, through direct effects on transcription, mediated by nuclear receptors, and also by triggering transduction pathways at the plasma membrane. At the same time, due to their effects on proliferation, differentiation, and cell metabolism, thyroid hormones may have a critical role in different kinds of cancer, including brain cancer. Abstract The development and maturation o…
Subjective Experience of Episodic Memory and Metacognition: A Neurodevelopmental Approach
2013
Episodic retrieval is characterized by the subjective experience of remembering. This experience enables the co-ordination of memory retrieval processes and can be acted on metacognitively. In successful retrieval, the feeling of remembering may be accompanied by recall of important contextual information. On the other hand, when people fail (or struggle) to retrieve information, other feelings, thoughts and information may come to mind. In this review, we examine the subjective and metacognitive basis of episodic memory function from a neurodevelopmental perspective, looking at recollection paradigms (such as source memory, and the report of recollective experience) and metacognitive parad…
Influences of prenatal and postnatal stress on adult hippocampal neurogenesis: The double neurogenic niche hypothesis
2015
International audience; Adult hippocampal neurogenesis (AHN) is involved in learning, memory, and stress, and plays a significant role in neurodegenerative and psychiatric disorders. As an age-dependent process, AHN is largely influenced by changes that occur during the pre- and postnatal stages of brain development, and constitutes an important field of research. This review examines the current knowledge regarding the regulators of AHN and the influence of prenatal and postnatal stress on later AHN. In addition, a hypothesis is presented suggesting that each kind of stress influences a specific neurogenic pool, developmental or postnatal, that later becomes a precursor with important repe…
Neuromagnetic studies of attention in children and youth: Role of exercise and impact on cognitive competence
2023
Tarkkaavuus on monella tavoin yhteydessä elimistömme sisäisiin ja ulkoisiin tekijöihin aivojen kehityksen aikana, jolloin aivot muovautuvat voimakkaasti. Tässä väitöskirjassa tutkitaan tarkkaavuutta kahdesta eri näkökulmasta: millä tavoin oma toimintamme vaikuttaa tarkkaavuuteen ja toisaalta miten tarkkaavuus moduloi muita kognitiivisia toimintoja. Tarkemmin sanottuna väitöskirjassa tutkitaan fyysisen aktiivisuuden ja aerobisen kunnon yhteyksiä ennakoivan tarkkaavuuden ja modaliteettien välisen tarkkaavuuden suuntaamisen aivoperustaan 13-17-vuotiailla nuorilla. Lisäksi väitöskirjassa tutkitaan millä tavoin tarkkaavuus vaikuttaa puheäänteiden ja ei-kielellisten äänteiden käsittelyyn aivoissa…