Search results for "bsa"
showing 10 items of 263 documents
A quoi sert le ministre du Travail ? Compte rendu de F. Rebsamen, En toutes confidences (Stock, 2016)
2017
François Rebsamen a été ministre du Travail en 2014-2015. Son livre, En toutes confidences, revient sur cette expérience ministérielle et plus largement sur son itinéraire politique. Son propos parfois incisif fait tout son intérêt. En outre, rares sont les ministres du Travail qui ont témoigné de leur rôle et l’ont fait sans trop de langue de bois. Le livre constitue donc une plongée dans l’univers des négociations avec les partenaires sociaux au plus haut niveau, de la fabrique ou du bricolage de réformes, puisque l’ancien ministre a laissé son nom à une loi relative au dialogue social et à l'emploi.
RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy
2014
Macroautophagy is a degradative pathway that sequesters and transports cytosolic cargo in autophagosomes to lysosomes, and its deterioration affects intracellular proteostasis. Membrane dynamics accompanying autophagy are mostly elusive and depend on trafficking processes. RAB GTPase activating proteins (RABGAPs) are important factors for the coordination of cellular vesicle transport systems, and several TBC (TRE2-BUB2-CDC16) domain-containing RABGAPs are associated with autophagy. Employing C. elegans and human primary fibroblasts, we show that RAB3GAP1 and RAB3GAP2, which are components of the TBC domain-free RAB3GAP complex, influence protein aggregation and affect autophagy at basal an…
Exploring the SARS-CoV-2 Proteome in the Search of Potential Inhibitors via Structure-based Pharmacophore Modeling/Docking Approach
2020
To date, SARS-CoV-2 infectious disease, named COVID-19 by the World Health Organization (WHO) in February 2020, has caused millions of infections and hundreds of thousands of deaths. Despite the scientific community efforts, there are currently no approved therapies for treating this coronavirus infection. The process of new drug development is expensive and time-consuming, so that drug repurposing may be the ideal solution to fight the pandemic. In this paper, we selected the proteins encoded by SARS-CoV-2 and using homology modeling we identified the high-quality model of proteins. A structure-based pharmacophore modeling study was performed to identify the pharmacophore features for each…
Improving the Representativeness of a Simple Random Sample: An Optimization Model and Its Application to the Continuous Sample of Working Lives
2020
This paper proposes an optimization model for selecting a larger subsample that improves the representativeness of a simple random sample previously obtained from a population larger than the population of interest. The problem formulation involves convex mixed-integer nonlinear programming (convex MINLP) and is, therefore, NP-hard. However, the solution is found by maximizing the size of the subsample taken from a stratified random sample with proportional allocation and restricting it to a p-value large enough to achieve a good fit to the population of interest using Pearson&rsquo
Detection of Hepatitis B Virus DNA in the Liver of Children with Chronic Hepatitis B by In Situ Hybridization and Its Relation to Other Viral Markers
1992
The aim of the study was to detect hepatitis B virus (HBV) DNA by in situ hybridization (ISH) with a 35S-labeled radioactive probe in frozen liver biopsy tissue sections of 63 hepatitis B virus surface antigen (HBsAg)-positive children. The results were compared to other markers of viral replication. HBV DNA was detected in 48 children. Of the 15 negative cases, four had hepatitis B envelope antigen (HBeAg), 10 anti-HBe, and one neither HBeAg nor anti-HBe. Free HBV DNA in serum and liver was positive in one patient. Forty of the positive children were HBeAg- and six anti-HBe-positive; two were negative for both. Of 45 36 had HBV DNA in serum. In 38 of 47 HBV DNA and in 31 of 42 HBcAg could …
Guide méthodologique d'analyse de la question enseignante: initiative pour la formation des enseignants en Afriqe subsaharienne (TTISSA) : guide pour…
2011
Ce guide vise à permettre une analyse des différentes dimensions de la question enseignante dans différents pays, avec l'objectif de construire une vision globale de cette question. Le travail qu'il vise à soutenir n'est donc pas descriptif mais plutôt analytique. Le but n'est pas de décrire tel ou tel aspect du système, tels que le déploiement des enseignants ou la formation, des fonctions, mais plutôt d'analyser les situations existantes et les résultats obtenus et de tenter d'identifier la gamme des options possibles dans le pays . L'analyse permet d'identifier les espaces de dialogue pour définir la politique de l'enseignant
Thermal aggregation of glycated Bovine Serum Albumin
2009
Does fragility of States affect realization of Education for all? An empirical essay
2009
More than one child out three, in the world, who don't access to school live in countries which are in conflict or which have governments non-engaged in politics of poverty reduction or which lacks of operating capacity. Given this, in these fragile States, mainly in Sub-Saharan Africa, universal primary schooling will be off target for 2015, so invalidate the Millennium Development Goals. Thus, does fragility of States constraints, in a practical way, the goal of Education for all? In this paper, explanations are provided and empirically tested using Qualitative Comparative Analysis (QCA). From the results, several types of fragilities represent major obstacles to achieving UPE. According …
Histokompatibilitäts-(HLA) Antigene bei Patienten mit HBsAg-positiver und -negativer chronisch aktiver Hepatitis und gesunden Trägern von HBsAg und A…
1976
Eine Analyse der Literatur und eigene Befunde uber die Haufigkeit von 23 HLA-Antigenen bei Patienten mit Hepatitis-Oberflachen-Antigen (HBsAg)-positiver und -negativer chronisch aktiver Hepatitis (CAH) und gesunden Tragern von HBsAg und Antikorpern gegen HBsAg (Anti-HBs) erlauben die folgenden Schlusfolgerungen: 1. Bei Patienten mit CAH und HBsAg-Persistenz findet sich eine normale Haufigkeit von HLA-B8 (und -A1). 2. Auch bei Patienten mit HBsAg-negativen Formen einer CAH ohne Autoimmunphanomene (AutoAk) ist die HLA-B8-Haufigkeit normal. 3. Nur Patienten mit HBsAg-negativer CAH mit AutoAk haben eine statistisch signifikant grosere Haufigkeit von HLA-B8 (und -A1) (p < 0,01 nach Korrektion fu…