Search results for "cART"

Polymeric monolithic microcartridges with gold nanoparticles for the analysis of protein biomarkers by on-line solid-phase extraction capillary elect…

2020

In this study, polymeric monoliths with gold nanoparticles (AuNP@monolith) were investigated as microcartridges for the analysis of protein biomarkers by on-line solid-phase extraction capillary electrophoresis-mass spectrometry (SPE-CE-MS). “Plug-and-play” microcartridges (7 mm) were prepared from a glycidyl methacrylate (GMA)-based monolithic capillary column (5 cm x 250 µm i.d.), which was modified with ammonia and subsequently functionalized with gold nanoparticles (AuNPs). The performance of these novel microcartridges was evaluated with human transthyretin (TTR), which is a protein related to different types of familial amyloidotic polyneuropathies (FAP). Protein retention depended on…

Géovisualisation des flux maritimes mondiaux,

2016

Conférence francophone Esri, Versailles, FRANCE, 05-/10/2016 - 06/10/2016; La planche présente trois possibilités de géo-visualisation des flux et mouvements de marchandises à l'échelle mondiale, en raison des problèmes spécifiques qui s'y posent.

3-Deazaneplanocin A (DZNep), an Inhibitor of the Histone Methyltransferase EZH2, Induces Apoptosis and Reduces Cell Migration in Chondrosarcoma Cells

2014

Objective Growing evidences indicate that the histone methyltransferase EZH2 (enhancer of zeste homolog 2) may be an appropriate therapeutic target in some tumors. Indeed, a high expression of EZH2 is correlated with poor prognosis and metastasis in many cancers. In addition, 3-Deazaneplanocin A (DZNep), an S-adenosyl-L homocysteine hydrolase inhibitor which induces EZH2 protein depletion, leads to cell death in several cancers and tumors. The aim of this study was to determine whether an epigenetic therapy targeting EZH2 with DZNep may be also efficient to treat chondrosarcomas. Methods EZH2 expression was determined by immunohistochemistry and western-blot. Chondrosarcoma cell line CH2879…

RILIEVO IN MODALITÀ DINAMICA DEL PARCO NINNI CASSARÀ A PALERMO E SVILUPPO DI UN APPLICATIVO PER LA GESTIONE DELLA MANUTENZIONE

2014

Nel corso degli anni le tecniche di monitoraggio hanno sviluppato una tendenza esponenziale verso la semplificazione e la velocizzazione, sia delle operazioni di rilievo, che di restituzione e analisi dei dati rilevati giungendo nel contempo a livelli di accuratezza sempre più spinti. Questo volgere continuo al miglioramento delle prestazioni tecnologiche e all’ottimizzazione delle risorse in termini di tempo e denaro, per gli addetti ai lavori, ha posto la moderna Geomatica in linea con la mentalità propria del terzo millennio di fare meglio e più in fretta. Tra le tecnologie che sempre più stanno prendendo campo in quest’ottica si inserisce il Mobile Mapping System che su una qualunque pi…

Using optical satellite and aerial imagery for automatic coastline mapping

2020

The continuous availability and rapid accessibility to multispectral data from satellite platforms within the Copernicus Programme represents a great opportunity for users in different fields of applications as: Agriculture, observation of coastal zones, monitoring land cover change. The aim of this paper is to identify a suitable method to map coastline using Sentinel-2 optical satellite image. The method provides the use of two indexes developed in remote sensing field for water environment: NDWI (Normalized difference water index) and MNDWI (Modified Normalized difference water index). Starting from the construction of maps of these indexes and, identifying appropriate threshold values, …

Camarada: la actividad sindical y profesional, las disposiciones oficiales, la renovación escolar lo recoge El Magisterio español Suscribete.

Del periòdic surt un feix de llum que sembla eixir d'una llàntia de gas que hi ha darrere

Mesenchymal stem cells derived from inflamed dental pulpal and gingival tissue: a potential application for bone formation

2017

Background Chronic periodontal disease is an infectious disease consisting of prolonged inflammation of the supporting tooth tissue and resulting in bone loss. Guided bone regeneration procedures have become common and safe treatments in dentistry, and in this context dental stem cells would represent the ideal solution as autologous cells. In this study, we verified the ability of dental pulp mesenchymal stem cells (DPSCs) and gingival mesenchymal stem cells (GMSCs) harvested from periodontally affected teeth to produce new mineralized bone tissue in vitro, and compared this to cells from healthy teeth. Methods To characterize DPSCs and GMSCs, we assessed colony-forming assay, immunophenot…

Coverage intervals for trace elements in human scalp hair are site specific.

2014

Coverage intervals for trace elements in human scalp hair commonly provide the basis for interpreting laboratory results and also in comparative decision-making processes regarding exposure risk assessment. This short communication documents, by some examples, that those computed for human hair are to be considered site specific, as they reflect local environmental conditions; also each geographic area has a typical profile of hair elemental composition of its inhabitants. Therefore, the levels of trace elements in hair are not strictly comparable between different areas of the world. This issue is particularly relevant when identification of anomalous environmental exposures are requested …

Identification of Novel pro-α2(IX) Collagen Gene Mutations in Two Families with Distinctive Oligo-Epiphyseal Forms of Multiple Epiphyseal Dysplasia

1999

Multiple epiphyseal dysplasia (MED) is a genetically heterogeneous disorder with marked clinical and radiographic variability. Traditionally, the mild "Ribbing" and severe "Fairbank" types have been used to define a broad phenotypic spectrum. Mutations in the gene encoding cartilage oligomeric-matrix protein have been shown to result in several types of MED, whereas mutations in the gene encoding the alpha2 chain of type IX collagen (COL9A2) have so far been found only in two families with the Fairbank type of MED. Type IX collagen is a heterotrimer of pro-alpha chains derived from three distinct genes-COL9A1, COL9A2, and COL9A3. In this article, we describe two families with distinctive ol…

Two-level resolution of relative risk of dengue disease in a hyperendemic city of Colombia.

2018

Risk maps of dengue disease offer to the public health officers a tool to model disease risk in space and time. We analyzed the geographical distribution of relative incidence risk of dengue disease in a high incidence city from Colombia, and its evolution in time during the period January 2009—December 2015, identifying regional effects at different levels of spatial aggregations. Cases of dengue disease were geocoded and spatially allocated to census sectors, and temporally aggregated by epidemiological periods. The census sectors are nested in administrative divisions defined as communes, configuring two levels of spatial aggregation for the dengue cases. Spatio-temporal models including…