Search results for "cache"
showing 9 items of 79 documents
SP0086 Promotion Exercise: The Evidence
2013
Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease, and the most common form of chronic joint inflammation. Inflammation leads to elevation of proinflammatory cytokines such as tumour necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP). RA also results in downregulation of anabolic factors for muscle, for example, muscle levels of insulin-like growth factor I (IGF-1) [1]. The circulating levels of cytokines reflect may also play a significant role in rheumatoid cachexia, which is defined as a loss of body cell mass which predominates in skeletal muscle [2]. Despite the significant improvement of pharmaceutical interventions, therapeutic exerci…
Oxidative Stress and Ubiquitin Ligases: their involvement in skeletal muscle atrophy
2015
Introduction Muscle atrophy plays a relevant role in the many very prevalent diseases. Generation of reactive oxygen species (mainly by the xanthine oxidase) and inflammation are two of the main triggers of muscle atrophy. Aim The major aim of our study was to determine the mechanism by which reactive oxygen species activate E3 ubiquitin ligases (MuRF-1 and MAFbx) cause muscle atrophy. Possible prevention by allopurinol, a well-known xanthine oxidase inhibitor widely used in clinical practice; and by indomethacin, a non-steroidal antiinflamatory drug was also studied. Materials and methods Male C57BL/6J mice (3 months old) conditioned by 14 days of hindlimb unloading with or without each tr…
Exercise medicine for cancer cachexia: targeted exercise to counteract mechanisms and treatment side effects.
2022
Abstract Purpose Cancer-induced muscle wasting (i.e., cancer cachexia, CC) is a common and devastating syndrome that results in the death of more than 1 in 5 patients. Although primarily a result of elevated inflammation, there are multiple mechanisms that complement and amplify one another. Research on the use of exercise to manage CC is still limited, while exercise for CC management has been recently discouraged. Moreover, there is a lack of understanding that exercise is not a single medicine, but mode, type, dosage, and timing (exercise prescription) have distinct health outcomes. The purpose of this review was to examine the effects of these modes and subtypes to identify the most opt…
Physiactisome: A New Nanovesicle Drug Containing Heat Shock Protein 60 for Treating Muscle Wasting and Cachexia.
2022
Currently, no commercially available drugs have the ability to reverse cachexia or counteract muscle wasting and the loss of lean mass. Here, we report the methodology used to develop Physiactisome—a conditioned medium released by heat shock protein 60 (Hsp60)—overexpressing C2C12 cell lines enriched with small and large extracellular vesicles. We also present evidence supporting its use in the treatment of cachexia. Briefly, we obtain a nanovesicle-based secretion by genetically modifying C2C12 cell lines with an Hsp60-overexpressing plasmid. The secretion is used to treat naïve C2C12 cell lines. Physiactisome activates the expression of PGC-1α isoform 1, which is di…
Decreasing muscle performance associated with increasing disease activity in patients with rheumatoid arthritis
2018
Objectives Increasing evidence suggests that inflammation has a detrimental effect on muscle strength. Our objective was to analyse the association between muscle performance and different disease activity levels in patients with rheumatoid arthritis (RA). Method A total of 199 consecutive outpatients were subject to cross-sectional assessment. Measurements of grip strength, endurance of the upper and lower limbs and trunk strength were combined as a muscle performance composite score (MPCS), using a standardised method. The disease activity for 28 joints (DAS28), radiographs of small joints (Larsen score), rheumatoid factor, body mass index (BMI), comorbidities and anti-rheumatic drugs wer…
Context-aware data caching for 5G heterogeneous small cells networks
2016
In this work, we investigate the problem of context-aware data caching in the heterogeneous small cell networks (HSCNs) to provide satisfactory to the end-users in reducing the service latency. In particular, we explore the storage capability of base stations (BSs) in HSCNs and propose a data caching model consists of edge caching elements (CAEs), small cell base stations (SBSs), and macro cell BS (MBS). Then, we concentrate on how to efficiently match the data contents to the different cache entities in order to minimize the overall system service latency. We model it as a distributed college admission (CA) stable matching problem and tackle this issue by utilizing contextual information t…
Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments
2021
Muscle wasting, i.e., cachexia, frequently occurs in cancer and associates with poor prognosis and increased morbidity and mortality. Anticancer treatments have also been shown to contribute to sustainment or exacerbation of cachexia, thus affecting quality of life and overall survival in cancer patients. Pre-clinical studies have shown that blocking activin receptor type 2 (ACVR2) or its ligands and their downstream signaling can preserve muscle mass in rodents bearing experimental cancers, as well as in chemotherapy-treated animals. In tumor-bearing mice, the prevention of skeletal and respiratory muscle wasting was also associated with improved survival. However, the definitive proof tha…
Learn to Cache: Machine Learning for Network Edge Caching in the Big Data Era
2018
The unprecedented growth of wireless data traffic not only challenges the design and evolution of the wireless network architecture, but also brings about profound opportunities to drive and improve future networks. Meanwhile, the evolution of communications and computing technologies can make the network edge, such as BSs or UEs, become intelligent and rich in terms of computing and communications capabilities, which intuitively enables big data analytics at the network edge. In this article, we propose to explore big data analytics to advance edge caching capability, which is considered as a promising approach to improve network efficiency and alleviate the high demand for the radio resou…
Slēpņošanas pieejas izmantošana ģeogrāfijas stundās
2018
Darba mērķis ir raksturot slēpņošanas pieejas izmantošanu ģeogrāfijas stundās Latvijas ģeogrāfijas tematos (ģeogrāfiskais stāvoklis, iedzīvotāji, teritoriālais izvietojums, klimats, augājs un dabas aizsardzība). Skolēniem, aktīvi darbojoties un meklējot slēpņus, paralēli bija iespēja apgūt dažādus tematus par Latvijas ģeogrāfiju, tādā veidā sasaistot interesanto ar lietderīgo. Izstrādātajā pētījumā pierādījās tas, ka, veicot uzdevumus, kuri tika iesaistīti aktivitātē, palielinājās kopējais skolēnu zināšanu līmenis. Uzdevumi tika izveidoti, pamatojoties uz Valsts izglītības un satura centra izstrādāto standartu un mācību programmu. Pētījumā tika apkopots vairāku ģeogrāfijas pedagogu viedokli…