Search results for "cadera"

showing 10 items of 15 documents

SNPs in bone-related miRNAs are associated with the osteoporotic phenotype

2017

AbstractBiogenesis and function of microRNAs can be influenced by genetic variants in the pri-miRNA sequences leading to phenotypic variability. This study aims to identify single nucleotide polymorphisms (SNPs) affecting the expression levels of bone-related mature microRNAs and thus, triggering an osteoporotic phenotype. An association analysis of SNPs located in pri-miRNA sequences with bone mineral density (BMD) was performed in the OSTEOMED2 cohort (n = 2183). Functional studies were performed for assessing the role of BMD-associated miRNAs in bone cells. Two SNPs, rs6430498 in the miR-3679 and rs12512664 in the miR-4274, were significantly associated with femoral neck BMD. Further, we…

0301 basic medicineconformation:Diseases::Wounds and Injuries::Fractures Bone::Hip Fractures [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings]Polimorfismo de nucleótido simpleGene ExpressionboneOsteoblastosDensidad ósea:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Cohort StudiesGene Frequencysingle nucleotide polymorphismBone DensityBone cellOssosgeneticsFracturas osteoporóticasCells CulturedGeneticsBone mineralMicroARNsMultidisciplinarymicroRNAbiologyQalleleR:Diseases::Wounds and Injuries::Fractures Bone::Osteoporotic Fractures [Medical Subject Headings]clinical trialMiddle Agedcohort analysisPhenotypeHumanosFenotipmedicine.anatomical_structureCancellous BoneosteoblastMedicine:Diseases::Musculoskeletal Diseases::Bone Diseases [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]:Anatomy::Cells::Connective Tissue Cells::Osteoblasts [Medical Subject Headings]AlelosFenotipomusculoskeletal diseasesmedicine.medical_specialtyGenotypeScienceSingle-nucleotide polymorphismBiologychemistryPolymorphism Single NucleotideArticleBone and Bones:Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Cancellous Bone [Medical Subject Headings]03 medical and health sciencesCalcification PhysiologicInternal medicinemicroRNAmedicineHumanshumanproceduresAllele:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles [Medical Subject Headings]AllelesFemoral neckGenetic associationAgedcell culture:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Density [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic::Polymorphism Single Nucleotide [Medical Subject Headings]OsteoblastsEnfermedades óseasFracturas de caderaComputational BiologyCuello femoral:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Antisense Elements (Genetics)::RNA Antisense::MicroRNAs [Medical Subject Headings]MicroRNAs030104 developmental biologyEndocrinologymulticenter studybone mineralizationNucleic Acid ConformationOsteoporosispathology:Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Bones of Lower Extremity::Leg Bones::Femur::Femur Neck [Medical Subject Headings]TranscriptomemetabolismGenotipoFractures
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Use of topical tranexamic acid in primary total hip arthroplasty. Efficiency and safety. Our experience.

2019

Abstract Background and aim Intravenous tranexamic acid has been shown to reduce bleeding and the need for transfusions in total hip arthroplasty, although it has a theoretical risk of producing thromboembolic phenomena. Recently some papers have been published using the topical application of tranexamic acid, but the ideal administration protocol has not yet been clearly defined. The aim of this paper was to demonstrate that our protocol of topical tranexamic acid is effective and safe. Methods Prospective data collection from a case series of 80 primary hip arthroplasties, in which the following topical tranexamic acid protocol is used: 1.5 g diluted to a total volume of 60 ml were admini…

AdultMalemedicine.medical_specialtyBlood transfusionAdministration TopicalArthroplasty Replacement Hipmedicine.medical_treatmentBlood Loss SurgicalProspective data030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineClinical ProtocolsmedicineHumansBlood TransfusionOrthopedics and Sports MedicineProspective StudiesAged030222 orthopedicsAdministración tópica Artroplastia total cadera Topical administration Total hip arthroplasty Tranexamic acid Ácido tranexámicobusiness.industryFemoral canalMiddle AgedAntifibrinolytic AgentsSurgeryTreatment Outcomemedicine.anatomical_structureTranexamic AcidAcido tranexamicoFemaleSurgerybusinessTranexamic acidmedicine.drugTotal hip arthroplasty
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Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

2020

The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located nearNEDD4LandSLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 d…

MaleGenetic-variationNedd4 Ubiquitin Protein LigasesPooled AnalysisBlood Pressure0302 clinical medicineHuman geneticsMendelian RandomizationYoung adultChildhealth care economics and organizationsBody mass indexAdiposityGenetics & Heredity0303 health sciencesStatistics1184 Genetics developmental biology physiologyGenomicsadulto3. Good healthCardiovascular DiseasesChild PreschoolPhysical SciencesMenarchegenetic-variationpresión sanguíneaMonosaccharide Transport ProteinsGenetic locieducationenfermedades cardiovascularesProstate-specific AntigenGenetic correlation03 medical and health sciencesSDG 3 - Good Health and Well-beingDiabetes MellitusGeneticsHumansprostate-specific antigenStatistical MethodsMolecular BiologyEcology Evolution Behavior and Systematicschildhood0604 Genetics[SDV.GEN]Life Sciences [q-bio]/GeneticsScience & TechnologyEarly Growth Genetics ConsortiumBiology and Life SciencesComputational Biologynutritional and metabolic diseasesSingle nucleotide polymorphismsMendelian Randomization AnalysisBiological TissueDiabetes Mellitus Type 2estudio de asociación genómica completagenetic factorsmendelian randomizationanálisis de la aleatorización mendelianaproteínas de transporte de monosacáridosBody mass index030217 neurology & neurosurgeryMathematicsDemographyDevelopmental BiologyCardiovascular RiskCancer ResearchobesityPhysiologyhumanosadolescenteOverweightQH426-470Genome-wide association studiesWaist–hip ratioMathematical and Statistical TechniquesMedicine and Health Sciencesbody mass index (BMI)Genetics of diseaseGenetics (clinical)2. Zero hungeradiposityMetaanalysisPhysiological ParametersConnective Tissue/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemalemedicine.symptomAnatomypooled analysisLife Sciences & BiomedicineResearch ArticleAdultcardiovascular riskAdolescentBirth weightmenarquiaAdipose tissueBiology3121 Internal medicineResearch and Analysis MethodsmedicineoverweightGenetic Predisposition to DiseaseObesity030304 developmental biologyMenarcheWaist-Hip Ratioíndice de masa corporalBody WeightCardiometabolic Risk Factorspredisposición genética a la enfermedadHeritabilityOverweightGenome Analysisyoung-adultsGenome-wide Associationíndice cintura-caderaYoung-adultsgenome-wide associationGenome-Wide Association StudyPLoS genetics
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Obesity indexes and total mortality among elderly subjects at high cardiovascular risk: The PREDIMED study

2014

Background: Different indexes of regional adiposity have been proposed for identifying persons at higher risk of death. Studies specifically assessing these indexes in large cohorts are scarce. It would also be interesting to know whether a dietary intervention may counterbalance the adverse effects of adiposity on mortality. Methods: We assessed the association of four different anthropometric indexes (waist-to-height ratio (WHtR), waist circumference (WC), body mass index (BMI) and height) with all-cause mortality in 7447 participants at high cardiovascular risk from the PREDIMED trial. Forty three percent of them were men (55 to 80 years) and 57% were women (60 to 80 years). All of them …

MaleGerontologymodelos de riesgos proporcionaleshumanosDieta mediterràniaBody Mass IndexWaist–hip ratioRisk FactorsMedicine and Health SciencesAbdominal obesitymediana edadAged 80 and overClinical Trials as TopicancianoMultidisciplinaryAnthropometryMortality rateHazard ratioQAge FactorsRMiddle AgedCardiovascular diseasesResearch DesignCardiovascular DiseasesPhysical SciencesObservational StudiesMedicineObesitatFemalemedicine.symptomWaist CircumferenceStatistics (Mathematics)Research ArticlePREDIMEDWaistClinical Research DesignScienceCardiologyenfermedades cardiovascularesResearch and Analysis Methodsensayos clínicos como asuntomedicineHumansfactores de riesgoObesityStatistical MethodsMortalityobesidadAgedProportional Hazards Modelsperímetro abdominalbusiness.industryWaist-Hip RatioMalalties cardiovascularsíndice de masa corporalAnthropometrymedicine.diseaseCardiovascular riskObesityíndice cintura-caderabusinessBody mass indexMathematicsMeta-AnalysisDemographyAntropometria
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Effect of a common exercise programme with an individualised progression criterion based on the measurement of neuromuscular capacity versus current …

2021

IntroductionHigh-load resistance training has shown positive effects in pain and function in lower limb tendinopathies. However, some authors suggest that current exercise programmes produce an increase in tolerance to load and exercise in general but without fixing some existing issues in tendinopathy. This may indicate the need to include training aspects not currently taken into account in the current programmes. The main objective of this study will be to compare the effect of a common exercise protocol for the three predominant lower limb tendinopathies (Achilles, patellar and gluteal), based on an individualised control of the dose and training of specific aspects of the neuromuscular…

Sports medicinehipFerides i lesions Tractamentknee:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Quality of lifeInformed consent:Anatomy::Body Regions::Extremities::Lower Extremity [Medical Subject Headings]:Anatomy::Musculoskeletal System::Tendons::Achilles Tendon [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Rehabilitation::Exercise Therapy [Medical Subject Headings]1506Randomized Controlled Trials as Topic:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings]foot & ankleMedicina física y rehabilitaciónRrehabilitation medicineGeneral MedicineExercise TherapyTreatment OutcomeLower Extremity:Anthropology Education Sociology and Social Phenomena::Social Sciences::Quality of Life [Medical Subject Headings]MedicineRodillamedicine.medical_specialtyBest practiceCaderaRehabilitation MedicineIntervention (counseling)medicineHumans1727:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings]Protocol (science)sports medicineFootbusiness.industryPieMedicina deportivamedicine.diseaseClinical trialTendinopathy:Diseases::Musculoskeletal Diseases::Muscular Diseases::Tendinopathy [Medical Subject Headings]Physical therapyQuality of LifeTobilloAnkleTendinopathyTendinitisbusiness
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Repercusión hemodinámica de la levobupivacaína isobárica y la bupivacaína hiperbárica para anestesia en cirugía de fractura de cadera

2015

La fractura de cadera en la población geriátrica es frecuente en los países desarrollados. La morbimortalidad perioperatoria puede estar influida por las técnicas anestésica y quirúrgica. Los cambios fisiopatológicos propios de la vejez, la asociación de comorbilidad, el tratamiento con diferentes fármacos y una reserva funcional reducida, hacen que la población anciana sea más vulnerable a los efectos farmacológicos de los fármacos en general, y particularmente los anestésicos generales y locales. Algunos estudios clínicos han demostrado que la bupivacaína (BUPI) y la levobupivacaína (LEVO) son igual de efectivos pero la menor afinidad que posee la LEVO por los canales de sodio en el coraz…

ancianoLevobupivacaínaBupivacaínafractura caderaUNESCO::CIENCIAS MÉDICAS:CIENCIAS MÉDICAS [UNESCO]bloqueo subaracnoideo
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Comparación de los resultados radiológicos, clínicos y analíticos de un vástago con cuello modular y su homólogo monobloque en la artroplastia total …

2022

Introducción: La artroplastia total de cadera es uno de los grandes hitos de la ortopedia moderna. Los vástagos con cuellos modulares fueron introducidos con la ventaja teórica de permitir un ajuste más exacto de la anatomía. La hipótesis de nuestro trabajo es que el vástago modular H-MAX M con cuellos intercambiables permite restaurar el offset femoral y la longitud de miembros, de forma más ajustada que con el vástago monobloque homólogo H-MAX S, obteniendo con ello mejores resultados clínico-funcionales sin añadir los riesgos de una elevación sérica de cromo ni cobalto. El objetivo de nuestro trabajo es comparar los resultados radiológicos, clínicos y analíticos de un vástago con cuell…

cobaltodisimetríaUNESCO::CIENCIAS MÉDICAScuestionario de saludoffset femoraliones metálicos:CIENCIAS MÉDICAS [UNESCO]modularidadescalas de saludcromoartroplastia cadera
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Utilización de cótilos de doble movilidad en cirugía protésica de cadera ¿pueden mejorar los óptimos resultados?

2022

Objetivo: El objetivo del estudio es evaluar la utilidad clínica de los cotilos de doble movilidad (DM) en cirugía protésica de cadera en diferentes escenarios clínicos, por un lado en cirugía de recambio acetabular y por otro como tratamiento primario de fracturas subcapitales. Métodos: Estudiamos una cohorte retrospectiva de pacientes a los que se realizó un recambio acetabular con cótilos de doble movilidad (DM) en el Hospital General de Valencia entre Marzo del 2007 y Marzo del 2019. Se realiza asimismo un estudio prospectivo caso-control que incluye 120 pacientes con fractura subcapital de cadera intervenidos entre Julio de 2016 y Marzo del 2020 los cuales se randomizaron a cótilos de …

doble movilidadprotesis de caderaUNESCO::CIENCIAS MÉDICAS
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Activación neuromuscular en un ejercicio de aducción de cadera en el medio acuático en función del material y la profundidad

2016

Las últimas tres décadas han sido prolíficas en cuanto a producción científica referida a los beneficios que la mejora de la condición física tiene sobre la salud y el rendimiento, así como a la forma de obtenerlos. Tradicionalmente, en el medio acuático dicha producción científica se ha concentrado en la natación competitiva, aunque debe resaltarse el hecho de que cada vez existen más estudios dedicados a los efectos agudos y crónicos del entrenamiento de la condición física en ejercicios acuáticos en posición vertical. En este sentido, el medio acuático se ha posicionado como un medio válido para la adquisición de dichos beneficios, de modo que es perfectamente viable conseguir mejoras en…

entrenamiento acuáticoejercicio unilateralUNESCO::CIENCIAS DE LA VIDAcoreelectromiografía de superficecadera:CIENCIAS DE LA VIDA [UNESCO]
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Creación de un instrumento de decisión objetivo para la indicación de tratamiento quirúrgico vs conservador en la fractura de cadera

2022

La mortalidad tras la fractura de cadera es elevada y conocer en el ingreso el riesgo de mortalidad podría ser de utilidad para ajustar la necesidad de cuidados pre y perioperatorios, ayudar a la toma de decisiones y permitir el ajuste de riesgo en auditorías. En el Hospital de la Ribera (Alzira) hemos creado un modelo que tras el ingreso por la fractura de cadera mida el riesgo de mortalidad a los 30 (Alzira Hip Fracture Score: AHFS-30) y 180 días (AHFS-180). Métodos: Se incluyeron 701 pacientes mayores de 69 años, ingresados de forma consecutiva por cualquier tipo de fractura de cadera. Se recogieron las variables asociadas a mortalidad en estudios previos. Se realizó una regresión logíst…

fractura de caderaUNESCO::CIENCIAS MÉDICASmortalidadvariables predictivas
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