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showing 10 items of 2320 documents
Variability in recording and scoring of respiratory events during sleep in Europe: a need for uniform standards.
2015
Abstract: Uniform standards for the recording and scoring of respiratory events during sleep are lacking in Europe, although many centres follow the published recommendations of the American Academy of Sleep Medicine. The aim of this study was to assess the practice for the diagnosis of sleep-disordered breathing throughout Europe. A specially developed questionnaire was sent to representatives of the 31 national sleep societies in the Assembly of National Sleep Societies of the European Sleep Research Society, and a total of 29 countries completed the questionnaire. Polysomnography was considered the primary diagnostic method for sleep apnea diagnosis in 10 (34.5%), whereas polygraphy was …
Natalizumab therapy of multiple sclerosis: recommendations of the Multiple Sclerosis Study Group-Italian Neurological Society
2011
Three years after the introduction of natalizumab (NA) therapy for the second line treatment of relapsing-remitting multiple sclerosis (MS), Italian MS centers critically reviewed the scientific literature and their own clinical experience. Natalizumab was shown to be highly efficacious in the treatment of MS. However, the risk of progressive multifocal leukoencephalopathy was confirmed and defined better. This article summarizes the MS-SIN Study Group recommendations on the use of NA in MS, with particular reference to the appropriate selection and monitoring of patients as well as to the management of adverse events.
Treating Sleep Disorders with an ACT-Based Behavior Change Support System
2017
Suitable duration and appropriate quality of sleep are essential for mental and cognitive wellbeing. Sleep disorders, whether mild or severe, have proven to have adverse effects on general wellbeing. One's quality of life could be disturbed as a consequence of various mental conditions, sleep disorders being one of them. Researchers have started paying attention to designing, implementing and evaluating eHealth interventions to address sleep disorders. In this chapter, we highlight findings from a field study that was conducted to evaluate effect of software features on a Web-based intervention for sleep disorders. Tyyne is a Web-based eHealth intervention that will be repeatedly mentioned …
Practical solutions to the challenges of uncontrolled hypertension: a white paper.
2008
This white paper is an urgent call to action from aninternational group of physicians. The continued failure tocontrolhypertensiontakesanunacceptabletollon patients,families and society and it must be addressed. Any patientwith blood pressure of 140/90 mmHg or greater can becharacterizedasa ‘challengingpatient’,is atsignificant risk,and requires persistent optimization of therapy until targetblood pressure is achieved. Six key challenges in reachingthis goal blood pressure are described: (1) inadequateprimary prevention; (2) faulty awareness of risk; (3) lack ofsimplicity; (4) therapeutic inertia; (5) insufficient patientempowerment; and (6) unsupportive healthcare systems.This white paper id…
Detection of central circuits implicated in the formation of novel pain memories
2016
Jaymin Upadhyay,1 Julia Granitzka,1 Thomas Bauermann,2 Ulf Baumgärtner,3 Markus Breimhorst,1 Rolf-Detlef Treede,3 Frank Birklein1 1Department of Neurology, 2Department of Neuroradiology, University Medical Centre, Johannes Gutenberg University Mainz, Mainz, 3Department of Neurophysiology, Center for Biomedicine and Medical Technology Mannheim (CBTM), Heidelberg University, Mannheim, Germany Abstract: Being able to remember physically and emotionally painful events in one’s own past may shape behavior, and can create an aversion to a variety of situations. Pain imagination is a related process that may include recall of past experiences, in addition to production of sensor…
REVIEW OF RETROSPECTIVE DOSIMETRY TECHNIQUES FOR EXTERNAL IONISING RADIATION EXPOSURES
2011
The current focus on networking and mutual assistance in the management of radiation accidents or incidents has demonstrated the importance of a joined-up approach in physical and biological dosimetry. To this end, the European Radiation Dosimetry Working Group 10 on 'Retrospective Dosimetry' has been set up by individuals from a wide range of disciplines across Europe. Here, established and emerging dosimetry methods are reviewed, which can be used immediately and retrospectively following external ionising radiation exposure. Endpoints and assays include dicentrics, translocations, premature chromosome condensation, micronuclei, somatic mutations, gene expression, electron paramagnetic re…
Adverse effects of iodine thyroid blocking: a systematic review
2011
(131)I, when released in a radiological or nuclear accident as happened recently in Fukushima, Japan, may cause thyroid cancer as a long-term consequence. Iodine thyroid blocking (ITB) is known to reduce the risk of developing thyroid cancer. Potential adverse effects of ITB have not been systematically investigated so far. This article summarises the results of a review on adverse effects of ITB based on a systematic literature search in scientific medical databases. A meta-analysis was not performed as identified studies displayed major heterogeneity. The search resulted in 14 articles relevant to the topic, reporting mostly on surveys, ecological and intervention studies. Only one study …
OC2.01: Examination of the fetal brain by three-dimensional ultrasound: potential for routine neurosonographic studies
2005
Objective: To evaluate the role of three-dimensional (3D) ultrasound in the assessment of the fetal brain and its potential for routine neurosonographic studies. Methods: We studied prospectively 202 consecutive brain fetuses between 16 and 24 weeks’ gestation. A 3D-ultrasound volume of the fetal head was acquired transabdominally. The entire brain anatomy was later analyzed by a sonologist expert in neonatal cranial sonography using the multiplanar images. The quality of the conventional planes obtained (coronal, sagittal and axial, at different levels) and the ability to visualize properly the major brain anatomic structures were evaluated. Results: Acceptable rendered cerebral volumes we…
Brain Morphometry and Psychobehavioural Measures in Autistic Low-Functioning Subjects
1997
In the last two decades neurological research has significantly increased knowledge on the neuroanatomic bases of autism. Several autopsy and quantitative magnetic resonance imaging (MRI) studies have reported central nervous system (CNS) abnormalities which may underlie the social, language and cognitive dysfunction typical of the autistic disorder.Despite the wealth of evidence that the “autistic brain” is different from normal in a number of structures, the relationship between the severity of the developmental impairment in autism and the degree of the brain abnormality remains unknown.The aim of the present study is to correlate the areas of some brain regions, as calculated on the bas…
Working Memory and the Enactment Effect in Early Alzheimer’s Disease
2014
This study examines the enactment effect in early Alzheimer’s disease using a novel working memory task. Free recall of action-object instruction sequences was measured in individuals with Alzheimer’s disease (n=14) and older adult controls (n=15). Instruction sequences were read out loud by the experimenter (verbal-only task) or read by the experimenter and performed by the participants (subject-performed task). In both groups and for all sequence lengths, recall was superior in the subject-performed condition than the verbal-only condition. Individuals with Alzheimer’s disease showed a deficit in free recall of recently learned instruction sequences relative to older adult controls, yet b…