6533b82bfe1ef96bd128e141
RESEARCH PRODUCT
REVIEW OF RETROSPECTIVE DOSIMETRY TECHNIQUES FOR EXTERNAL IONISING RADIATION EXPOSURES
Carita LindholmFirouz DarroudiVadim V. ChumakIvan VeroneseElena BakhanovaPaola FattibenePaola FattibeneElizabeth A. AinsburyHorst RommVirgilio CorrecherSimon HornUrsula OestreicherMaurizio MarraleMaurizio MarraleFrançois TrompierAndrzej WojcikAnne VralI. GucluAlbrecht WieserUlrike KulkaO. Monteiro GilJoan Francesc BarquineroAlicja JaworskaB. RakicDavid LloydClemens WodaP. VoisinKai RothkammMaria BraiMaria BraiJ. PajicGaëtan GruelCaroline A. WhitehouseAnna LongoAnna Longosubject
medicine.medical_specialtyProtein biomarkersOptically stimulated luminescence[SDV]Life Sciences [q-bio]Radiation DosageRisk AssessmentRetrospective dosimetry030218 nuclear medicine & medical imagingIonizing radiation03 medical and health sciences0302 clinical medicineRadiation MonitoringRadiation IonizingHumansMedicineDosimetryRadiology Nuclear Medicine and imagingMedical physicsRadiometryRetrospective StudiesRadiationRadiological and Ultrasound Technologybusiness.industryPublic Health Environmental and Occupational HealthGeneral MedicineIntegrated approach030220 oncology & carcinogenesisBody BurdenRadiation monitoringbusinessIonising radiation exposureRadiation Accidentsdescription
The current focus on networking and mutual assistance in the management of radiation accidents or incidents has demonstrated the importance of a joined-up approach in physical and biological dosimetry. To this end, the European Radiation Dosimetry Working Group 10 on 'Retrospective Dosimetry' has been set up by individuals from a wide range of disciplines across Europe. Here, established and emerging dosimetry methods are reviewed, which can be used immediately and retrospectively following external ionising radiation exposure. Endpoints and assays include dicentrics, translocations, premature chromosome condensation, micronuclei, somatic mutations, gene expression, electron paramagnetic resonance, thermoluminescence, optically stimulated luminescence, neutron activation, haematology, protein biomarkers and analytical dose reconstruction. Individual characteristics of these techniques, their limitations and potential for further development are reviewed, and their usefulness in specific exposure scenarios is discussed. Whilst no single technique fulfils the criteria of an ideal dosemeter, an integrated approach using multiple techniques tailored to the exposure scenario can cover most requirements. © The Author 2010. Published by Oxford University Press. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-11-30 |