Search results for "camp"
showing 10 items of 1995 documents
Respiration and low cAMP-dependent protein kinase activity are required for high-level expression of the peroxisomal thiolase gene in Saccharomyces c…
1996
Transcription of genes for peroxisomal proteins is repressed by glucose and induced by oleate. At least for the peroxisomal thiolase gene (POT1) there is a third regulatory mechanism, mediated by the transcription factor Adr1p, which is responsible for the high-level expression of the gene in stationary phase. Here we show that a region in the POT1 promoter that extends from positions -238 to -152 mediates this mechanism, and we suggest that Adr1p acts indirectly on POT1. We have also analyzed the role of the cAMP-dependent protein kinase (PKA) in the transcriptional regulation of POT1. PKA exerts a negative control: the high, unregulated PKA activity in a bcy1 mutant maintains POT1 transcr…
Inflation, quantum fields, and CMB anisotropies
2009
Revert field Inflationary cosmology has proved to be the most successful at predicting the properties of the anisotropies observed in the cosmic microwave background (CMB). In this essay we show that quantum field renormalization significantly influences the generation of primordial perturbations and hence the expected measurable imprint of cosmological inflation on the CMB. However, the new predictions remain in agreement with observation, and in fact favor the simplest forms of inflation. In the near future, observations of the influence of gravitational waves from the early universe on the CMB will test our new predictions.
The actual management of colorectal liver metastases
2020
Colorectal cancer is one of the most frequent cancers in the world and between 50% and 60% of patients will develop colorectal liver metastases (CRLM) during the disease. There have been great improvements in the management of CRLM during the last decades. The combination of modern chemotherapeutic and biological systemic treatments with aggressive surgical resection strategies is currently the base for the treatment of patients considered unresectable until few years ago. Furthermore, several new treatments for the local control of CRLM have been developed and are now part of the arsenal of multidisciplinary teams for the treatment of these complex patients. The aim of this review was to s…
Restrictions on data-driven political micro-targeting in Germany
2017
The revitalisation of canvassing in recent elections is strongly related to campaigns´ growing possibilities for analysing voter data to gain knowledge about their constituents, identifying their most likely voters and serving up personalised messages through individual conversations. The research literature about political micro-targeting hardly ever focusses on campaigns in parliamentary democracies with strict data protection laws. Based on in-depth expert interviews we introduce a framework of constraints in strategic political communication and reveal several restrictions on the macro, meso and micro levels which hinder the implementation of sophisticated data strategies in Germany. We…
nota, Tribunale di Reggio Emilia, sentenza 22 aprile 2015
2015
Risponde ex art. 2048 c.c. il circolo tennis che organizzi attività ginnica su un campo di beach volley ove s’infortuni una minore in allenamento sotto la supervisione di un istruttore dipendente del circolo, posto che, in caso di danni cagionati nei confronti di soggetti incapaci (ivi compresi i minori), la ratio della disposizione di cui all'art. 2048 c.c. deve essere ricercata nell'inadempimento di un obbligo di vigilanza assunto dal responsabile in relazione a particolari categorie di soggetti, che per presunzione di legge, non sono totalmente capaci di rapportarsi correttamente con la realtà esterna; e che in tale ipotesi l'obbligo di vigilanza si deve conformare all'età dei soggetti a…
Redes de dependencia mutua entre señores y criados en el condado de Paredes (siglos XV y XVI)
2017
Villanos y hombres buenos. La élite campesina en el mundo rural hispano durante la época moderna
2021
La "competenza partenopea" per i reati riferiti alla gestione dei rifiuti e in materia ambientale, in Aa.Vv., Le nuove norme sulla sicurezza pubblica…
2008
Interpretazione delle nuove disposizioni contenute nel d.l. 23 maggio 2008, conv. nella l. 14 luglio 2008, n.90.
C'era una volta il campo Rom di Palermo
2019
Questo breve articolo discute dell'esclusione sociale della popolazione rom che vive nella città di Palermo e della chiusura di quello che è stato per vari decenni un vero e proprio ghetto. The brief article tackles the issue of social exclusion experienced by Roma people. The author provides a reading of a brief report linked to the local news to look at the shaping of the figure of the ‘enemies of a culture’
Les campagnes des Tricasses
2017
Since the 1990s, preventive archaeology has brought to light an abundance of documentation in the western part of Champagne (the "chalky" Champagne) which now makes it possible to define the nature of rural settlements from the late Iron Age and Roman times. Unlike the neighbouring regions of Burgundy or Picardy, where excavations and aerial prospecting had revealed the presence of numerous enclosed grave sites then attributed to the end of La Tène and masonry settlements of all sizes dating back to Roman times, these data were previously lacking in Champagne.