Search results for "canaux"

Involvement of Kv3.1 potassium chanels in 7-ketocholesterol, 24S-hydroxycholesterol and C24 : 0-induced lipotoxicity on 158N and BV-2 cells : relatio…

2017

Potassium (K+) is involved in the regulation of cellular excitability, cell cycle regulation, cell viability, neuroprotection and maintenance of microglial and oligodendrocytic functions. Potassium dysfunction, described in several neurodegenerative diseases such as Alzheimer's Disease (AD), multiple sclerosis (MS), Parkinson's disease and Huntington's disease, may be a potential therapeutic target. The underlying toxic mechanisms of these neurodegenerative pathologies involve oxysterols, which are oxidized cholesterol derivatives, and fatty acids including those associated with peroxisomal metabolism. 7-ketocholesterol (7KC), 24S-hydroxycholesterol (24S-OHC) and tetracosanoic acid (C24:0),…

A new actor involved in hypothalamic glucose detection : the Transient Receptor Potential Canonical (TRPC) channels

2015

Hyperglycemia is detected and integrated by the mediobasal hypothalamus (MBH) which, in turn, inhibits food intake and triggers insulin secretion. The MBH houses specialized glucose-sensitive (GS) neurons, which directly or indirectly modulate their electrical activity in response to changes in glucose level. In a first study, we hypothesized that indirect detection of glucose by MBH GS neurons involves the secretion of endozepine by astrocytes, a gliotransmitter known to inhibit food intake in response to hyperglycemia. The present work shows that endozepines selectively activate anorexigenic MBH pro-opiomelanotortine (POMC) neurons. In the second study, we show that the direct detection o…

La distribution : organisation et stratégie

2020

Croissance rapide de nouvelles formes de vente, stratégies de mutualisation des ressources logistiques, phygitalisation, plateformisation, politique de réenchantement des points de vente... Autant de bouleversements du paysage économique qui font désormais de la distribution une fonction clé de la gestion des entreprises. Comprendre et expliquer à la fois sa dynamique et ses enjeux revêt, à ce titre, une importance majeure. Rédigé par trois spécialistes reconnus du sujet, l'ouvrage se fixe pour objectif d'aborder de façon pédagogique les principales dimensions de la distribution : la relation avec l'acheteur final, la gestion des interfaces entre industriels et distributeurs, et les enjeux …

Intégration perçue des canaux de distribution par les consommateurs : mesure et modélisation

2012

Quantitative study of cardiac wall motion from cine-MRI using frequency-based optical flow methods

2010

The aim of this thesis is to study parietal desynchronisation of the left ventricle from conventional cine-MRI. The first part of our work consisted in the quantification of the left ventricle wall motion of the heart directly from conventional retrospective SSFP type cine-MRI sequences used in the study of cardiac function. The developed methods for measuring displacements within the images are frequency-based optical flow methods. These techniques seem to be particularly adapted to MRI specificities. We have demonstrated their robustness in the event of Rician noise and pixel intensity variations as a function of time. These variations are often associated with the through-plane motion of…

Systèmes financiers et canaux de transmission de la politique monétaire

2010

This dissertation analyses the consequences of transformations in the financial sphere on the transmission channels of decisions in monetary policy in industrialized countries over the past several years. We observe that as a result of these transformations, banking institutions have evolved from an originate to hold model to an originate to distribute model. This has enabled banks to turn more toward derivative products and credit risk transfer instruments. We demonstrate that these techniques of active/passive management have completely revolutionized the theoretical foundations of traditional channels and in particular the credit channel. Our analysis of these landmark changes is organiz…

Des canaux Ioniques de la membrane plasmique lors de la mort cellulaire programmée induite par l’ozone chez A. thaliana

2011

Tropospheric ozone is a major secondary pollutant. In addition to its role in greenhouse effect gas, ozone is one of the most toxic air pollutants, and its pollution affects both human health and crop productivity. The work presented in this thesis concerns the role of ion channels in the plasma membrane in response to acute exposure to ozone and their interactions with signaling events leading to O3-induced PCD in A. Thaliana cultured cells. We have shown that cell death was genetically controlled and characterized by cell shrinkage similar to the mechanism of "Apoptosis Volume Decrease" (AVD) described in animal. This process is initially promoted by an early activation of a plasma membra…

Microglia and α-synuclein implication in Parkinson's disease

2011

Age-related neurodegenerative disorders like Parkinson’s disease take an enormous toll on individuals and on society. Despite extensive efforts, Parkinson’s disease remains incurable and only very limited treatments exist. Indeed, Parkinson’s pathogenesis is still not clear and research on its molecular mechanisms is ongoing. In this study, we focused our interest on two abnormal events occurring in Parkinson’s patients, namely α-synuclein aggregation and microglial activation. We first investigated α-synuclein and its abnormal polymerisation. For this purpose, we developed novel methods, which allowed the in vitro production of different types of α-synuclein oligomers. Using highly sensiti…

Développer la confiance à l’égard d’une enseigne multicanal de prêt-à-porter: Le rôle clef de l’intégration perçue des canaux de distribution

2015

Intégration perçue des canaux de distribution et confiance à l’égard d’une enseigne multicanal : cas des enseignes de prêt-à-porter

2013

L’objectif de cette étude est de montrer la nécessité d’intégrer les canaux de distribution d’une enseigne multicanal, en s’appuyant sur le point de vue des consommateurs. Un modèle de recherche basé sur une étude qualitative et une revue critique de la littérature existante est proposé. Il vise à tester l’impact de l’intégration perçue des canaux de distribution (IPCD) sur la confiance envers l’enseigne, à travers des études quantitatives exploratoires et confirmatoires. Les tests statistiques ont révélé des liens à très forte portée managériale pour les clicks and mortar de prêt-à-porter, notamment les effets de l’intégration perçue des canaux de distribution sur les dimensions de la conf…