Search results for "capabilities"

showing 10 items of 119 documents

DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY

2015

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin belongs to the family of small leucine-rich proteoglycans (SLRP) and is involved physiologically in the fibrillogenesis of collagen. In the last few year a new anti-oncogenic role has been proposed for decorin1. This study aimed to implement the knowledge on the effects of ectopic decorin on breast cancer cells using as a reference point the results already achieved by our research group2 on the experimental model format. By breast cancer cell line 8701-BC and its transfected clone DEC-C2. The extension of the proteomic analysis combined with the mass spectrometry allowed to triplicate the number of identified proteins in our model. Among the newly identified proteins were members of the classes of metabolic enzymes S100 family and cell motility proteins which revealed a net decrease in the decorin transfected cells. Of considerable importance is the observation that these classes of proteins are the most involved in metastatic progression. These results confirm and reinforce the anti-oncogenic role hypothesized for decorin. The work was co-funded by the Italian 5x1000 to COBS.DECORIN
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The Importance of Internal Resources and Capabilities and Destination Resources to Explain Firm Competitive Position in the Spanish Tourism Industry

2015

This study draws on the Resource-Based View to analyze the effects of distinctive competences in tourism firms and location in a tourism district on competitive position, and explores the moderating effects of the tourism destination. Multiple linear regression was used to test the research hypotheses on a sample of 1019 Spanish tourism firms. Results reveal that financial resources and dynamic and production capabilities favor a better competitive position for tourism firms in general; however, coordination and marketing capabilities are key factors for firms embedded in a tourism district, while dynamic capabilities have a negative effect in this case. Copyright © 2015 John Wiley & Sons, …

Tourism geography05 social sciencesGeography Planning and DevelopmentTransportationSample (statistics)Key factorsResource (project management)Tourism Leisure and Hospitality Management0502 economics and businessEconomicsPosition (finance)Production (economics)MarketingDynamic capabilities050203 business & management050212 sport leisure & tourismTourismNature and Landscape ConservationInternational Journal of Tourism Research
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Responsible I(m)ovation in Asia Pacific regions

2022

AbstractOver the past 20 years, a debate has developed on the differences between innovation and imitation strategies as mechanisms by which businesses operating in the Asia Pacific region may gain a competitive advantage. The current research contributes to this debate from a different perspective by exploring some of the challenges and opportunities associated with the combination of both strategies into what has been defined as imovation. Imovators and imovations do not stand alone in business ecosystems. Rather, they should be embraced in the context of sustainability-related virtues and emerging capabilities, such as ethical behaviour, co-responsibility and positive social impact. Taki…

VDP::Samfunnsvitenskap: 200::Økonomi: 210:Samfunnsvitenskap: 200 [VDP]Strategy and ManagementEconomics Econometrics and Finance (miscellaneous)Business and International ManagementResponsible imovation Asia Pacific region Dynamic capabilities Innovation ImitationAsia Pacific Journal of Management
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Exploring the relationship between big data analytics capability and competitive performance : The mediating roles of dynamic and operational capabil…

2020

A central question for information systems (IS) researchers and practitioners is if, and how, big data can help attain a competitive advantage. To address this question, this study draws on the resource-based view, dynamic capabilities view, and on recent literature on big data analytics, and examines the indirect relationship between a firm’s big data analytics capability (BDAC) and competitive performance. The study extends existing research by proposing that BDACs enable firms to generate insight that can help strengthen their dynamic capabilities, which, in turn, positively impact marketing and technological capabilities. To test our proposed research model, we used survey data from 202…

VDP::Teknologi: 500::Informasjons- og kommunikasjonsteknologi: 550::Datateknologi: 551Information Systems and ManagementKnowledge managementbusiness.industryComputer scienceBig data030508 substance abuseOperational capabilities02 engineering and technologyCompetitive advantageStructural equation modelingManagement Information Systems03 medical and health sciencesResource (project management)020204 information systems0202 electrical engineering electronic engineering information engineeringInformation systemSurvey data collectionDynamic capabilities0305 other medical sciencebusinessInformation Systems
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THE DEVELOPMENT OF THE RESOURCE BASED FIRM BETWEEN VALUE APPROPRIATION AND VALUE CREATION

2005

Various authors have brought forth the idea that the increase in context turbulence and the relentless change in today’s economic and competitive environments have rendered it essential for an effective firm strategy to combine both value appropriation and value creation (Porter, (1996); Moran & Ghoshal, (1999); Venkataraman & Sarasvathy, (2001); Hitt et al., (2001b). Nonetheless, the methodological bases and the assumptions that characterize contributions concerning value appropriation and value creation are notably different and in many respects opposite to one another. These profound methodological differences hinder the possibility of a combined consideration of value appropriation and …

VIEWCOMPETITIVE ADVANTAGECORPORATIONKNOWLEDGESTRATEGIC MANAGEMENT RESEARCHDYNAMIC CAPABILITIESRENTUSEFUL PERSPECTIVE
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How technology-based firms become also highly innovative firms? The role of knowledge, technological and managerial capabilities, and entrepreneurs’ …

2019

To what extent is the likelihood that a Technology-Based Firm – TBF – turns into a Technology-Based and Highly Innovative Firm – TB&InnF – is influenced by technical capabilities or managerial capabilities and education background? We analyse this question using a novel data panel assembled for 326 Spanish industrial firms, along the period 1998–2014. Our findings show the probability of becoming a TB&InnF growths when firms are able to accumulate a high endowment of knowledge and technological capabilities, and a managerial team with experience, a strong power position and previous technical or managerial education background. Results also indicate the CEO's educational profile in manageme…

Value (ethics)Economics and EconometricsEndowmentScopusEntrepreneurial educationPower (social and political)Management of Technology and Innovationddc:6500502 economics and businesslcsh:AZ20-999Technology-Based & Highly Innovative FirmBusiness and International Managementlcsh:Social sciences (General)Entrepreneurial educationIndustrial organizationManagerial capabilitiesMarketingComputingMilieux_THECOMPUTINGPROFESSION05 social sciencesTechnological capabilitieslcsh:History of scholarship and learning. The humanitiesKnowledge-based capabilitiesPosition (finance)050211 marketinglcsh:H1-99Business050203 business & managementJournal of Innovation & Knowledge
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Post-entry internationalisation activity of retailers

2013

Purpose – The purpose of this paper is to propose a framework, based on empirical research, to explain the strategic processes of post-entry development in international retailing through consideration of the dynamic capabilities attributable to retailers. Design/methodology/approach – Case study approach of five international retail firms using secondary data and primary data gathered through interviews with firms ' executives and financial analysts. Findings – The research findings, in the light of the existing literature, suggest a framework that makes a distinction between first level or generic dynamic capabilities relevant to the internationalization process and second level or speci…

Value (ethics)business.industryProcess (engineering)media_common.quotation_subjectInternational businessManagement Science and Operations ResearchClothingGeneral Business Management and AccountingInternationalizationEmpirical researchOriginalityBusinessDynamic capabilitiesMarketingIndustrial organizationmedia_commonManagement Decision
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The implications of dynamic capacities vis-à-vis competitiveness and innovation in the 21st century

2013

The theoretical transition being apparent in the analysis of internal competitive advantage sources is being dealt with in this paper. A theoretical approach is being applied which is focused on those processes allowing companies to upkeep and enhance their competitiveness, become adapted to changes, and become able to foresee changes in the market. This survey shows the eclectic nature of dynamic capacities bringing in dynamic elements into static-nature theories, and further addresses the biases being apparent in these two approaches both in the theoretical setting and in the managerial practice. This survey also looks into the generation, development and change processes pertaining with …

aprendizagem organizacionalinnovaciónDynamic capabilitiesCapacidades dinámicasorganizational learninginovaçãoCapacidades dinâmicasaprendizaje organizacionalinnovation
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Formal property rights in the face of the substantial right to housing

2016

This paper explores the dichotomy between formal property rights and use value of rights in the field of the right to housing for homeless people, focusing on the entitlement of the squatting practices to claim the collective rights in the public domain. This collective claim can be considered an alternative to the ‘traditional’ conception of the public property as 'exclusive' domain of State. In the cities of Southern Europe, urban space has become an ‘object’ of contention by groups of inhabitants, who are organized at various levels, and an object of claiming – through illegal (although not illegitimate) forms of occupation of public or social private properties – the right to housing as…

capabilities approach right to housing squattingsquattingcapabilities approachright to housingSettore ICAR/21 - Urbanistica
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The classification of the capabilities of the firm

2023

Purpose: The aim of this article is to present an identification of the premises for the classification of firm capabilities and to show the types of firm capability classification found in the literature. Design/methodology/approach: The classification of capability groups presented in this article is based on the literature review conducted. Findings: Standard classification of a firm's capabilities, in addition to structuring existing knowledge in the area of capabilities, can provide a starting point for identifying the firm's key capabilities leading to competitive advantage. Practical implications: Identifying a firm's capabilities is one of the key steps in creating and leveraging ca…

capabilitiesclassification of capabilitiesZeszyty Naukowe Politechniki Śląskiej. Organizacja i Zarządzanie
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