Search results for "castle"
showing 10 items of 41 documents
TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment.
2005
AbstractMast cells play an important role in host defense against various pathogens, but their role in viral infection has not been clarified in detail. dsRNA, synthesized by various types of viruses and mimicked by polyinosinic-polycytidylic acid (poly(I:C)) is recognized by Toll-like receptor 3 (TLR3). In this study, we demonstrate that poly(I:C) injection in vivo potently stimulates peritoneal mast cells to up-regulate a number of different costimulatory molecules. Therefore, we examined the expression and the functional significance of TLR3 activation in mast cells. Mast cells express TLR3 on the cell surface and intracellularly. After stimulation of mast cells with poly(I:C) and Newcas…
In vitro expansion and analysis of T lymphocyte microcultures obtained from the vaccination sites of cancer patients undergoing active specific immun…
1993
In order to understand further the effects of Newcastle-disease-virus(NDV)-modified tumour vaccines we investigated the feasibility of isolating lymphocytes from the site of injection of patients undergoing postoperative active specific immunization (ASI) with autologous NDV-modified tumour cells. Delayed-type-hypersensitivity(DTH)-like reactions from five cancer patients were surgically removed, minced and the tissue particles were digested with collagenase and DNase. Lymphoid cells recovered were expanded in a highly efficient limiting-dilution analysis system optimized for T cell growth [Moretta et al. (1983) J Exp Med 157: 743] and lymphocyte microcultures (clonal probability > 0.8) cou…
Il rilievo fotogrammetrico del Castello di Maredolce a Palermo
2014
Le tecniche di rilievo fotogrammetrico stanno trovando un sempre più largo impiego nel campo dei BB.CC. Esse, infatti, consentono una rappresentazione dei manufatti con un'elevata cura del dettaglio geometrico mediante la restituzione vettoriale ed una elevata definizione degli aspetti materici degli oggetti attraverso la realizzazione dei fotopiani, che forniscono informazioni sia metriche che qualitative dell'oggetto. Tali tecniche, pertanto, costituiscono un fondamentale strumento di supporto alle attività di diagnostica e restauro dei monumenti antichi. Il presente articolo illustra la metodologia, le fasi operative e gli strumenti impiegati per il rilievo fotogrammetrico di un edificio…
Update I. A systematic review on the efficacy and safety of chloroquine/hydroxychloroquine for COVID-19
2020
Purpose To assess efficacy and safety of chloroquine (CQ)/hydroxychloroquine (HCQ) for treatment or prophylaxis of COVID-19 in adult humans. Materials and methods MEDLINE, PubMed, EMBASE and two pre-print repositories (bioRxiv, medRxiv) were searched from inception to 8th June 2020 for RCTs and nonrandomized studies (retrospective and prospective, including single-arm, studies) addressing the use of CQ/HCQ in any dose or combination for COVID-19. Results Thirty-two studies were included (6 RCTs, 26 nonrandomized, 29,192 participants). Two RCTs had high risk, two ‘some concerns’ and two low risk of bias (Rob2). Among nonrandomized studies with comparators, nine had high risk and five moderat…
Działalność Zagranicznego Komitetu Odbudowy Zamku Królewskiego w Warszawie (1967–1972)
2018
Zdecydowana większość emigracyjnych elit politycznych zajęła negatywne stanowisko w sprawie zbiórki pieniędzy na restytucję Zamku Królewskiego w Warszawie. W 1. połowie lat 70. XX w. na całym świecie działało jednak kilkadziesiąt komitetów i organizacji polonijnych wspierających ową inicjatywę, najwięcej w Stanach Zjednoczonych, Australii, we Francji i w Kanadzie. Chronologicznie pierwszy tego typu komitet zawiązał się jeszcze w czerwcu 1967 r. w Londynie, na kilka lat przed decyzją władz PRL w sprawie podniesienia z ruin byłej siedziby królewskiej. Przewodniczącym Zagranicznego Komitetu Odbudowy Zamku Królewskiego w Warszawie został Ignacy Czaykowski. W skład komitetu weszły osoby, które w…
Marienburg in Livland
1911
Atsevišķs novilkums no: Zeitung für Wehrbau, Wohnung und Städtebau "Der Burgwart", Jahrgang XII, Heft 2, 1911.
Report of a case of localized Castleman's disease with progression to malignant lymphoma.
1993
Shining castles and humans of metal/floral appearance ? metaphorical language in the Palaiologan romances Kallimachos and Velthandros
2019
About eight centuries after Heliodorus, the Greek novel resurfaced in the twelfth century, in Komnenian Byzantium, and again two centuries later under the Palaiologan dynasty. This latter literary revival was due to the political stability of the imperial Byzantine government, which promoted cultural production, rhetorical education, and patronage networks. Kallimachos and Velthandros, two Palaiologan romances presented as court literature, combine ancient and medieval tropes with rhetorical artistry to blur the boundaries between the artificial and the natural. Castles and objects made of precious metals thus resemble living, natural spaces, and human characters are portrayed in metallurgi…
Ageing and production of the cytokines in Chernobyl clean-up workers from Latvia
2009
Ageing and production of the cytokines in Chernobyl clean-up workers from Latvia Chronic low-grade inflammation with subsequent impairment of immune system function promotes the development of age-related diseases, such as cancers, degenerative and infection diseases. It is not yet clear, if exposure to ionising radiation accelerates the aging process. The aim of the present work was to estimate the production of several cytokines by peripheral blood cells of Latvia's Chernobyl clean-up workers depending on age. ELISA was employed to determine the plasma level of sIL-1β and sIL-6 as well as level of IL-4 and TNF-α spontaneous and 24h and 96h after in vitro stimulation of peripheral blood mo…
Pandemic H1N1 influenza-associated myocarditis in a patient with Castleman's disease.
2013
We report on a patient with longstanding multicentric Castleman’s disease, hyaline-vascular type, who presented with nearly-fatal myocarditis associated with a 2009 pandemic H1N1 influenza virus infection. This is the first case of such an association described in the literature.