Search results for "cause"
showing 10 items of 6525 documents
Hla-Bb,Dr3 Phenotype and the Antibody Response Against Epstein-Barr Virus
1993
Antibodies against the viral capsid antigen (VCA) and nuclear antigens (EBNAs) of the Epstein-Barr virus (EBV) were determined in a sample of Sicilian population. A significant correlation was observed between HLA-BB,DR3 phenotype and reduced titres of antibodies to EBNAs, whereas HLA-BB,DR3 positive individuals displayed levels of antibodies to VCA comparable to those of HLA-BB,DR3 negative ones. These results further strenghten the suggestion that HLA-BB,DR3 positive subjects are low responders and that the depth of immune response depends on on the fashion of antigenic challenge.
Morphomechanics of the humero-ulnar joint: I. Joint space width and contact areas as a function of load and flexion angle
1995
BACKGROUND Previous studies have shown that the trochlear notch is deeper than necessary for an exact fit with the humerus. However, humero-ulnar joint space width and contact areas have so far not been quantified for variations in the load and angle of flexion. METHODS Six fresh cadaveric specimens were investigated at 30 degrees, 60 degrees, 90 degrees, and 120 degrees of flexion and at loads of 25 and 500 N, simulating resisted elbow extension. The joint space width and contact were determined, using polyether casting material. RESULTS At 25 N all joints made contact in the ventral and dorsal aspects of the articular surfaces, whereas in the depth of the trochlear notch the joint space w…
Treatment of distal intraarticular tibial fractures: A biomechanical evaluation of intramedullary nailing vs. angle-stable plate osteosynthesis
2015
In factures of the distal tibia with simple articular extension, the optimal surgical treatment remains debatable. In clinical practice, minimally invasive plate osteosynthesis and intramedullary nailing are both routinely performed. Comparative biomechanical studies of different types of osteosynthesis of intraarticular distal tibial fractures are missing due to the lack of an established model. The goal of this study was first to establish a biomechanical model and second to investigate, which are the biomechanical advantages of angle-stable plate osteosynthesis and intramedullary nailing of distal intraarticular tibial fractures. Seven 4(th) generation biomechanical composite tibiae feat…
The effect of cement fixation on initial micromotion of the femoral component in condylar knee replacement
1992
Four fresh, cadaveric specimens were fitted with total knee replacements and mounted on a knee joint loading and measuring rig. Femoral component micromotion in the sagittal plane was measured with a transducer during flexion and extension of the specimen. Various condylar designs were used without and with cement. Movement followed a characteristic curve pattern and was less with cement fixation particularly for bone of low trabecular strength as determined by bone sample tests for stiffness. Cement fixation appears to be superior to cementless fixation.
Eight new mutations and the expanding phenotype variability in muscular dystrophy caused by ANO5.
2012
Objective: Description of 8 new ANO5 mutations and significant expansion of the clinical phenotype spectrum associated with previously known and unknown mutations to improve diagnostic accuracy. Methods: DNA samples of 101 patients in 95 kindreds at our quaternary referral center in Finland, who had undetermined limb-girdle muscular dystrophy (LGMD), calf distal myopathy, or creatine kinase (CK) elevations of more than 2,000 IU/L, were selected for ANO5 genetic evaluation, and the clinical findings of patients with mutations were retrospectively analyzed. Results: A total of 25 patients with muscular dystrophy caused by 11 different recessive mutations in the ANO5 gene were identified. The …
Performance Evaluation for a Sustainable Supply Chain Management System in the Automotive Industry Using Artificial Intelligence
2020
Increasing the sustainability of a system can be achieved by evaluating the system, identifying the issues and their root cause and solving them. Performance evaluation translates into key performance indicators (KPIs) with a high impact on increasing overall efficacy and efficiency. As the pool of KPIs has increased over time in the context of evaluating the supply chain management (SCM) system&rsquo
ENABLING LOCAL GOVERNMENTS TO DESIGN AND IMPLEMENT ANTI-CORRUPTION STRATEGIES THROUGH DYNAMIC PERFORMANCE MANAGEMENT AND GOVERNANCE. A CASE-STUDY OF …
2021
Lo scopo principale di questa ricerca è quello di inquadrare le possibili relazioni causali fra corruzione negli approvvigionamenti pubblici e performance delle amministrazioni locali. A tal fine, viene adottato un disegno di ricerca che integra dinamicamente metodi quantitativi e qualitativi in ogni fase del processo di studio. Gli approcci Dynamic Performance Management (DPM) e Governance (DPG), supportati da interviste approfondite non-strutturate, modellazioni formali e simulazioni quantitative, sono qui adottati per analizzare un caso di studio rappresentativo di un piccolo comune italiano in cui si sono verificati alcuni episodi di corruzione nelle attività di approvvigionamento nei p…
Il nesso di causalita` materiale nella responsabilita` contrattuale e la ripartizione dell’onere della prova
2019
Il saggio prende le mosse da un orientamento della Suprema Corte, in corso di consolidamento, che ritiene il nesso di causalita` nella responsabilita` professionale del medico oggetto di prova distinta rispetto all’inadempimento o alla colpa, addossandone l’onere al creditore. In tal modo, le due specie della responsabilita` civile, contrattuale e aquiliana, non divergerebbero sul versante del requisito della causalita` ed e` questo un esito sistematico di cui si puo` fondatamente dubitare. A un esame approfondito, l’intero impianto dell’orientamento si rivela piuttosto fragile per una pluralita` di ragioni che pero` sono tutte riconducibili all’errore di fondo di trascurare le specificita`…
Etiological factors of chronic hepatitis in Italy: a 2014 national survey.
2017
Background The last Italian prevalence survey on chronic hepatitis (CH) conducted in 2001 showed that the hepatitis C virus (HCV) was the main agent associated with CH. Aim The aim of this study was to evaluate epidemiological changes in CH occurring after 13 years. Patients and methods Enrollment of 1392 CH consecutive patients referred to 16 Italian liver units in 2014 scattered all over the country (four in the North, four in the Center, four in the South, and four in the Islands) was performed. Results The mean age of the patients was 58.3 years, with a sex ratio (male/female) of 1.5. HCV infection (also with other etiologies) continues to be the most prevalent etiology (58.1%). However…
Noziedzības cēloņi un to novēršana
2017
Bakalaura darba “Noziedzības cēloņi un to novēršana” mērķis ir sociālas problēmas iespējamo patieso cēloņu noskaidrošana, piedāvājot saprātīgus risinājumus to novēršanai. Kriminoloģiskā domāšana pieļauj starpdisciplināru izpēti, kas nav ierobežota ar juridiskiem terminiem vien. Lai arī tas uzdevumu padara grūtāku, mēģinājums tiks veikts. Par būtiskāko problēmjautājumu autors uzskata noziedzīga nodarījuma izdarītāja “brīvo gribu”, jo tā aizvien ir krimināltiesību pamatā, tomēr var izrādīties tikai ilūzija. Tiks aplūkoti divi galvenie ietekmējošo faktoru kopumi. Autors saglabā pārliecību, ka gudra šo faktoru ņemšana vērā var noziedzības novēršanu padarīt daudz efektīvāku.