Search results for "centric"
showing 10 items of 389 documents
Wavefront invasion for a chemotaxis model of Multiple Sclerosis
2016
In this work we study wavefront propagation for a chemotaxis reaction-diffusion system describing the demyelination in Multiple Sclerosis. Through a weakly non linear analysis, we obtain the Ginzburg–Landau equation governing the evolution of the amplitude of the pattern. We validate the analytical findings through numerical simulations. We show the existence of traveling wavefronts connecting two different steady solutions of the equations. The proposed model reproduces the progression of the disease as a wave: for values of the chemotactic parameter below threshold, the wave leaves behind a homogeneous plaque of apoptotic oligodendrocytes. For values of the chemotactic coefficient above t…
Insulator proteins contribute to expression of gene loci repositioned into heterochromatin in the course ofDrosophilaevolution
2019
AbstractPericentric heterochromatin inDrosophilais generally composed of repetitive DNA forming a transcriptionally repressive environment. Nevertheless, dozens of genes were embedded into pericentric genome regions during evolution ofDrosophilidaelineage and retained functional activity. However, factors that contribute to “immunity” of these gene loci to transcriptional silencing remain unknown. Here, we investigated molecular evolution of the essentialMybandRanbp16genes. These protein-coding genes reside in euchromatic loci of chromosome X inD. melanogasterand related species, while in other studiedDrosophilaspecies, including evolutionary distant ones, they are located in genomic region…
Linker histone H1 is essential for Drosophila development, the establishment of pericentric heterochromatin, and a normal polytene chromosome structu…
2009
We generated mutant alleles of Drosophila melanogaster in which expression of the linker histone H1 can be down-regulated over a wide range by RNAi. When the H1 protein level is reduced to ∼20% of the level in wild-type larvae, lethality occurs in the late larval – pupal stages of development. Here we show that H1 has an important function in gene regulation within or near heterochromatin. It is a strong dominant suppressor of position effect variegation (PEV). Similar to other suppressors of PEV, H1 is simultaneously involved in both the repression of euchromatic genes brought to the vicinity of pericentric heterochromatin and the activation of heterochromatic genes that depend on their pe…
Localization of amplified CAD genes on rearranged chromosomes of Chinese hamster cells
2012
Chinese hamster cell lines carrying an amplified CAD region were selected from V79,B7 cells by their resistance to N-phosphonacetyl-L-aspartate (PALA). In one of the selected cell lines, SP PALA (inf1) (supR) L, an acrocentric chromosome with abnormally elongated q arms was identified as a marker for the PALA-resistant phenotype. The marker chromosome carried a homogeneously staining region close to a telomeric nucleolar organizer region. In the same region, localization of amplified CAD sequences was demonstrated by in situ hybridization. The marker chromosome was found to undergo extensive rearrangements. In particular, dicentric chromosomes, occurring with an unusually high incidence, we…
Signature of the presence of a third body orbiting around XB 1916-053
2015
The ultra-compact dipping source \object{XB 1916-053} has an orbital period of close to 50 min and a companion star with a very low mass (less than 0.1 M$_{\odot}$). The orbital period derivative of the source was estimated to be $1.5(3) \times 10^{-11}$ s/s through analysing the delays associated with the dip arrival times obtained from observations spanning 25 years, from 1978 to 2002. The known orbital period derivative is extremely large and can be explained by invoking an extreme, non-conservative mass transfer rate that is not easily justifiable. We extended the analysed data from 1978 to 2014, by spanning 37 years, to verify whether a larger sample of data can be fitted with a quadra…
Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites
2002
AbstractEnhancer of Zeste is a Polycomb Group protein essential for the establishment and maintenance of repression of homeotic and other genes. In the early embryo it is found in a complex that includes ESC and is recruited to Polycomb Response Elements. We show that this complex contains a methyltransferase activity that methylates lysine 9 and lysine 27 of histone H3, but the activity is lost when the E(Z) SET domain is mutated. The lysine 9 position is trimethylated and this mark is closely associated with Polycomb binding sites on polytene chromosomes but is also found in centric heterochromatin, chromosome 4, and telomeric sites. Histone H3 methylated in vitro by the E(Z)/ESC complex …
Measurement of residual stresses by the hole-drilling method: Influence of hole eccentricity
1979
The hole-drilling method is a semidestructive technique which allows the measurement of residual stresses. In this method, a source of error is due to the misalignment between the hole and rosette centres. This paper presents a theoretical analysis of the influence of such misalignment on the strains measured by the rosette. Formulae which give the residual stresses taking account of the hole eccentricity are derived. Finally, the errors, which affect the residual stresses when the eccentricity is neglected, are evaluated for some commercial strain-gauge rosettes especially developed for the hole-drilling method.
Review of Some Development of the Hole Drilling Method
1990
This paper contains a survey of some developments of the hole drilling method. It is mainly based on the research work carried out at the University of Palermo in the years from 1978 to 1989. The paper considers the relationship between the relaxed strain and the residual stresses for a rosette with an off-centre hole, the influence of hole eccentricity on the determination of residual stresses and of rosette calibration constants, the sensitivity of strain relaxation.
Relationship between radial and concentric cracking of tomato fruit
1983
Abstract A study with 62 genotypes was carried out to establish correlations existing between the percentages of fruits showing concentric cracks of more or less than 2 cm and radial cracks of more or less than 2 cm, considering both early and total production. Over a determined productive period, the susceptibility to form large or small cracks was controlled by the same genetic system (rG = 0.89 – 0.95), yet there was a genetic difference between susceptibility to radial and concentric cracking (rG = 0.53 – 0.68). Genetic systems for susceptibility to radial and concentric cracking seemed to show similarly over the first harvesting and over the total productive period ( r G ⋍ 1 ). Environ…