Search results for "changing"
showing 10 items of 96 documents
ATP1A2 mutations in 11 families with familial hemiplegic migraine.
2005
Abstract Familial hemiplegic migraine (FHM) is an autosomal dominant form of migraine with aura. The disease is caused by mutations of at least three genes among which two have been identified, CACNA1A and ATP1A2. Very few mutations have been identified so far in ATP1A2. We screened the coding sequence of ATP1A2 in 26 unrelated FHM probands in whom CACNA1A screening was negative. A total of eight different mutations were identified in 11 of the probands (41%), including six missense mutations, one small deletion leading to a frameshift, and one in frame deletion. All were novel mutations. Two mutations were recurrent, in three and two families, respectively. Genotyping of 94 relatives of th…
Structural analysis of Borrelia burgdorferi periplasmic lipoprotein BB0365 involved in Lyme disease infection.
2019
The periplasmic lipoprotein BB0365 of the Lyme disease agent Borrelia burgdorferi is expressed throughout mammalian infection and is essential for all phases of Lyme disease infection; its function, however, remains unknown. In the current study, our structural analysis of BB0365 revealed the same structural fold as that found in the NqrC and RnfG subunits of the NADH:quinone and ferredoxin:NAD+ sodium-translocating oxidoreductase complexes, which points to a potential role for BB0365 as a component of the sodium pump. Additionally, BB0365 coordinated Zn2+ by the His51, His55, His140 residues, and the Zn2+ -binding site indicates that BB0365 could act as a potential metalloenzyme; therefore…
Multiple nodal solutions for semilinear robin problems with indefinite linear part and concave terms
2017
We consider a semilinear Robin problem driven by Laplacian plus an indefinite and unbounded potential. The reaction function contains a concave term and a perturbation of arbitrary growth. Using a variant of the symmetric mountain pass theorem, we show the existence of smooth nodal solutions which converge to zero in $C^1(\overline{\Omega})$. If the coefficient of the concave term is sign changing, then again we produce a sequence of smooth solutions converging to zero in $C^1(\overline{\Omega})$, but we cannot claim that they are nodal.
Age differences in the irrelevant sound effect: A serial recognition paradigm
2015
In adults, the disrupting effect of irrelevant background sounds with distinct temporalspectral variations (changing-state sounds) on short-term memory performance was found to be robust. In the present study, a verbal serial recognition task was used to investigate this so-called Irrelevant Sound Effect (ISE) in adults and 8- to 10-year-old children. An essential part of the short-term memory impairment during changing-state speech is due to interference processes (changing-state effect) which can be differentiated from the deviation effect of auditory distraction. In line with recent findings (Hughes et al., 2013), our study demonstrates that the changing-state effect is not modulated by …
VLPZ: The Vehicular Location Privacy Zone
2016
International audience; One of the key challenges in the success of vehicular ad hoc networks (VANETs) is to consider the location privacy of drivers. Although, the pseudonym changing approach is suggested by standardization development organizations such as IEEE and ETSI, the development of an effective pseudonym changing strategy is still an open issue. The existing pseudonym changing strategies are either not effective to protect against the pseudonyms linking attacks or can have a negative impact on the VANETs’ applications. To address these issues, this paper proposes a new pseudonym changing strategy based on the Vehicular Location Privacy Zone (VLPZ), which is a roadside infrastructu…
Pump currents generated by the purified Na+K+-ATPase from kidney on black lipid membranes.
1985
The transport activity of purified Na+K+-ATPase was investigated by measuring the electrical pump current induced on black lipid membranes. Discs containing purified Na+K+-ATPase from pig kidney were attached to planar lipid bilayers in a sandwich-like structure. After the addition of only microM concentrations of an inactive photolabile ATP derivative [P3-1-(2-nitro)phenylethyladenosine 5'-triphosphate, caged ATP] ATP was released after illumination with u.v.-light, which led to a transient current in the system. The transient photoresponse indicates that the discs and the underlying membrane are capacitatively coupled. Stationary pump currents were obtained after the addition of the H+, N…
A search for flavour changing neutral currents in top-quark decays in pp collision data collected with the ATLAS detector at root s=7 TeV
2012
A search for flavour changing neutral current (FCNC) processes in top-quark decays by the ATLAS Collaboration is presented. Data collected from pp collisions at the LHC at a centre-of-mass energy of √s = 7 TeV during 2011, corresponding to an integrated luminosity of 2.1 fb[superscript −1], were used. A search was performed for top-quark pair-production events, with one top quark decaying through the t → Zq FCNC (q = u, c) channel, and the other through the Standard Model dominant mode t → W b. Only the decays of the Z boson to charged leptons and leptonic W -boson decays were considered as signal. Consequently, the final-state topology is characterised by the presence of three isolated cha…
Acidic Environment Leads to ROS-Induced MAPK Signaling in Cancer Cells
2011
Tumor micromilieu often shows pronounced acidosis forcing cells to adapt their phenotype towards enhanced tumorigenesis induced by altered cellular signalling and transcriptional regulation. In the presents study mechanisms and potential consequences of the crosstalk between extra- and intracellular pH (pH(e), pH(i)) and mitogen-activated-protein-kinases (ERK1/2, p38) was analyzed. Data were obtained mainly in AT1 R-3327 prostate carcinoma cells, but the principle importance was confirmed in 5 other cell types. Extracellular acidosis leads to a rapid and sustained decrease of pH(i) in parallel to p38 phosphorylation in all cell types and to ERK1/2 phosphorylation in 3 of 6 cell types. Furth…
Speed-dependent line profile: A test of a unified model from the Doppler to the collisional regime for molecule-molecule collisions
2000
International audience; A speed-dependent line profile combining soft and hard fully correlated Dicke-narrowing collisions was recently successfully tested on Ar-broadened H-2 spectra in a wide density and temperature range. A further test for mixtures of H-2 in nitrogen molecules (instead of Ar atoms) is presented. This test is also based on high resolution Raman investigation of the isotropic Q(1) line of H-2 from low to high density at various temperatures. The same consistency of the speed-dependent line profile as for H-2-Ar is obtained for H-2-N-2 through a remarkable agreement with all the data by using a unique set of four parameters (the collisional width and shift, the kinetic fre…
Collisional effects on spectral line shape from the Doppler to the collisional regime: A rigorous test of a unified model
2000
International audience; The paper presents high resolution Raman investigations of the Q(1) line of H-2 in Ar mixture from low density (Doppler regime) to high density (collisional regime) analyzed with a unique line shape profile. Measurements are performed by stimulated Raman gain spectroscopy between 300 and 1000 K in a wide density range (from 0.2 to 11 amagat). All the observed spectral features are accurately described by a unified model recently proposed by two of the authors. This model accounts for a velocity-memory process, not restricted to the usual hard and soft limits. It also includes correlation between velocity- and phase-changing collisions. An exhaustive analysis of vario…