Search results for "characteristics"
showing 10 items of 909 documents
Exploring Neighborhood Influences on Small-Area Variations in Intimate Partner Violence Risk: A Bayesian Random-Effects Modeling Approach
2014
This paper uses spatial data of cases of intimate partner violence against women (IPVAW) to examine neighborhood-level influences on small-area variations in IPVAW risk in a police district of the city of Valencia (Spain). To analyze area variations in IPVAW risk and its association with neighborhood-level explanatory variables we use a Bayesian spatial random-effects modeling approach, as well as disease mapping methods to represent risk probabilities in each area. Analyses show that IPVAW cases are more likely in areas of high immigrant concentration, high public disorder and crime, and high physical disorder. Results also show a spatial component indicating remaining variability attribut…
Drug gastrointestinal absorption in rat: Strain and gender differences.
2015
Predictive animal models of intestinal drug absorption are essential tools in drug development to identify compounds with promising biopharmaceutical properties. In situ perfusion absorption studies are routinely used in the preclinical setting to screen drug candidates. The objective of this work is to explore the differences in magnitude and variability on intestinal absorption associated with rat strain and gender. Metoprolol and Verapamil absorption rate coefficients were determined using the in situ closed loop perfusion model in four strains of rats and in both genders. Strains used were Sprague-Dawley, Wistar-Han, Wistar-Unilever, Long-Evans and CD∗IGS. In the case of Metoprolol only…
Interaction risk with proton pump inhibitors in general practice: significant disagreement between different drug-related information sources.
2006
Aims To compare information on drug–drug interactions (DDIs) reported on two standard drug-related information sources (Summary of Product Characteristics and Drugdex system by Micromedex), by assessing the prevalence and predictors of potential DDI with proton pump inhibitors (PPIs) in general practice. Methods From the ‘Caserta-1’ Local Health-Service database, 156 general practitioners (GPs) were recruited. From more than 180 000 individuals registered on their lists, we selected patients receiving co-prescription of PPI and medications at interaction risk, according to the Italian Summary of Product Characteristics (SPC) of PPI and Drugdex information, during the year 2003. Thereafter, …
Gender difference in drug use in hospitalized elderly patients.
2015
Purpose The aims of this study were to evaluate whether or not there are gender differences in drug use at hospital admission and prescription at discharge and to evaluate the effect of hospitalization on medication patterns in the elderly. Method In-patients aged > 65 years included in the REPOSI registry during a recruitment period of 3 years (2008-2010-2012) were analyzed in order to evaluate drug use at hospital admission and prescription at discharge according to gender. Results A total of 3473 patients, 52% women and 48% men, were considered. Polypharmacy (> 5 drugs) is more frequent in men both at hospital admission and discharge. At hospital discharge, the number of prescripti…
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Cephalexin Monohydrate.
2019
Literature data and results of experimental studies relevant to the decision to allow waiver of bioequivalence studies in humans for the approval of immediate release solid oral dosage forms containing cephalexin monohydrate are presented. Solubility studies were performed in accordance with the current biowaiver guidelines of the Food and Drug Administration, World Health Organization and European Medicines Agency, taking the degradation at some pH values into consideration. Together with solubility and permeability data for cephalexin monohydrate from the literature, it was demonstrated to be a Biopharmaceutics Classification System Class 1 drug. The pharmacokinetic behavior, results of b…
Safety of the current drug treatments for vitiligo
2020
Introduction: Vitiligo is an acquired depigmenting skin disorder adversely affecting the patient's quality of life. Despite the presence of several treatment modalities, ranging from medical to physical to surgical options, none is curative. Each modality has its own drawbacks and side effects. Thus, the treatment modality needs to be tailored for each individual patient taking into consideration the disease characteristics and also its efficacy and safety to obtain a favorable risk-benefit ratio.Areas covered: This review highlights the different treatment modalities utilized in vitiligo up until 4 November 2019 along with their adverse effects and contraindications, if any.Expert opinion:…
Disleksija, kā skolēni ar disleksiju var labāk mācīties skolā
2021
Šī maģistra darba mērķis ir definēt disleksiju, noteikt disleksijas raksturīgās iezīmes, izglītot skolotājus, lai viņi ikdienā saskartos ar skolēniem, kuriem ir šāds traucējums, spētu palīdzēt viņiem mācību procesā un, galvenokārt, paaugstināt viņu pašcieņu, un likt viņiem justies apmierinātiem ar sevi, izmantojot mūsdienās pieejamos tehnoloģiskos resursus. Šim nolūkam tika izmantota racionāla metode. Pētījuma dalībniece ir 12 gadus veica meitene no Limas, kas atrodas Perū, un viņas skolotāji, kuri tika konsultēti un atbalstīti. Šai meitenei nesen tika diagnosticēta disleksija. Iepriekš tika noteiktas vairākas nepareizas diagnozes. Rezultātā svarīgi bija izprast viņas vājās un stiprās puses…
La inseparabilidad y el grado de adaptación como determinantes de la internacionalización de las empresas de servicios
2005
-Esther.Sanchez@uv.es -Jose.Pla@uv.es La mayor parte de enfoques teóricos de internacionalización han surgido en el marco del sector industrial y, por tanto, algunas explicaciones podrían no ser generalizables al sector servicios en su globalidad. Por ello, las características sectoriales deben ser tenidas en cuenta en el análisis de los modos de entrada de las empresas de servicios, ya que es posible encontrar patrones de comportamiento muy diferentes no sólo con respecto a las empresas industriales sino también entre las propias empresas de servicios. En este trabajo se proponen la inseparabilidad de los servicios y el grado de adaptación a las necesidades del cliente como dimensiones cla…
Local Spatio-Temporal Log-Gaussian Cox Processes for seismic data analysis
2022
We propose a local version of the spatio-temporal log-Gaussian Cox processes (LGCPs) employing the Local Indicators of Spatio-Temporal Association (LISTA) functions into the minimum contrast procedure to obtain space as well as time-varying parameters. We resort to the joint minimum contrast method fitting method to estimate the set of second-order parameters for the class of Spatio-Temporal LGCPs. We employ the proposed methodology to analyse real seismic data occurred Greece between 2004 and 2015.
Urban segregation and unemployment: A case study of the urban area of Marseille – Aix-en-Provence (France)
2018
International audience; In this paper, we study the effects of the spatial organization of the urban area of Marseille – Aix-en-Provence on unemployment there. More specifically, differences in the characteristics of the residential population induce urban stratification with the result that urban structure may affect the probability of employment. In order to evaluate the effects of spatial structure on unemployment, we implement a spatial probit model to reveal the employment probabilities of young adults still living with their parents. Our results support the hypothesis that living in or near a deprived neighborhood decreases the probability of employment.