Search results for "choline"

ChemInform Abstract: Synthesis and Muscarinic Activity of Isoxazole-Substituted 1,2,5,6- Tetrahydropyridines.

2010

ChemInform Abstract: Design and Pharmacology of Quinuclidine Derivatives as M2-Selective Muscarinic Receptor Ligands.

2010

Time-dependent monomerization of gramicidin A, enhanced by phosphatidylcholine in non-polar solvents

1986

Abstract The usefulness of size-exclusion high-performance liquid chromatography for the study of gramicidin A dimer—monomer conformational equilibrium in non

Influence of a hydrophilic spacer on the structure of a phospholipid monolayer

1994

We present the results of thermodynamical and X-ray grazing incidence diffraction experiments performed on Langmuir monolayers of ether lipids with hydrophilic spacers between the glycerol backbone and the phosphatidylcholine head group: DHPC, DH-E01-PC, and DH-E02-PC. As a spacer the oxy-ethylene group is used, which is a typical hydrophilic unit of non-ionic tensides. It turns out that the introduction of the hydrophilic spacers leads to a fluidization of the monolayer and reduces the tilt angle of the chains.

Stimulatory influence of ethanol on the septohippocampal cholinergic pathway. A role for GABA receptors?

1998

Hydrodynamic chromatography for characterization and purification of liposomes

1989

Membrane Lipid-Polypeptide Molecular Associations in Non Aqueous Solvent. Effect of Phosphatidylcholine Concentration and Temperature and their Influ…

1986

Abstract The use of an Ultrastyragel 500 A column for the study of interactions between phosphatidylcholine and gramicidin A in tetra-hydrofuran is described. Analysis of vacant peak has allowed to establish the influence that eluent lipid composition, concentration of injected gramicidin and temperature have on the interaction. At 20[ddot] C, for the assayed phospholipid concentration range (0.04 to 0.14 %, w/v), the lipid/polypeptide molar binding ratio, BR, varies from 1.3 to 6.9. An increase in temperature from 20 to 40[ddot] C causes a decrease in BR of about 20 %. On the other hand, the interaction releases some of the water bound to the lipid polar head, suggesting that the binding i…

Acetylcholine At Motor Nerves: Storage, Release, and Presynaptic Modulati On By Autoreceptors and Adrenoceptors

1992

Publisher Summary This chapter focuses on the modulation of acetylcholine release from the motor endplate by presynaptic receptors. An individual neuron can regulate its function, the release of transmitters or modulators, through the activation of local feedback loops. After escaping the neuronal membrane and entering the synaptic cleft (or extracellular space), the transmitter activates both the receptors localized at the endorgan (postsynaptic receptors) and the receptors localized at the nerve terminal within its diffusion radius (so-called presynaptic or neuronal receptors). Stimulation of presynaptic receptors triggers the generation of intracellular signals that modify ion channels o…

ChemInform Abstract: Synthetic Approaches Towards Huperzine A and B

2015

Huperzine A and B are potent acetylcholinesterase inhibitors and promising against Alzheimer's disease. Completed and formal total syntheses of these medically relevant alkaloids are presented and discussed.

Phorbol Esters and Muscarinic Receptor Agonists Activate Phospholipase D in Heart and Brain

1991

Phospholipase D (PLD) hydrolyzes phosphatidylcholine and thereby seems to play a key role in a novel pathway of signal transduction. PLD activity in rat hippocampal slices and atria of rat, guinea pig and chicken hearts was determined by measuring the catalytic products choline (Ch), phosphatidic acid (PA) and, in the presence of a primary alcohol, phosphatidylpropanol or phosphatidylethanol. It was found that the PLD activity was high, even under resting conditions, in both tissues, especially in the hippocampus, and that the enzyme activity could be enhanced by activation of protein kinase C and by muscarinic receptor stimulation.