Search results for "chromatin structure"

showing 3 items of 13 documents

The distributions of protein coding genes within chromatin domains in relation to human disease.

2019

Abstract Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wide interaction maps shows functional consequences that extend the initial thought of an efficient DNA packaging mechanism: gene regulation, DNA repair, chromosomal translocations and evolutionary rearrangements seem to be only the peak of the iceberg. One key concept emerging from this research is the topologically associating domains (TADs) whose functional role in gene regulation and their association with disease is not fully untangled. Resul…

lcsh:QH426-470Computational biologyBiologyChromatin structureCell LineChromosome conformation captureOpen Reading FramesGene expressionDatabases GeneticGeneticsEnhancersHumansDiseaseEnhancerMolecular BiologyGeneRegulation of gene expressionHousekeeping genesTopologically associating domainsResearchHuman diseasesTADGenes associated with diseaseHuman geneticsChromatinChromatinHousekeeping geneGene regulationlcsh:GeneticsEnhancer Elements GeneticTranscription Initiation SiteChromatin interactionsEpigeneticschromatin
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Should Contact Bans Have Been Lifted More in Germany?

2020

Abstract Many countries consider the lifting of restrictions of social contacts (RSC). We quantify the effects of RSC for Germany. We initially employ a purely statistical approach to predicting prevalence of Covid-19 if RSC had been upheld after 20 April. We employ these findings and feed them into our theoretical model. We find that the peak of the number of sick individuals would have been reached already end of April. The number of sick individuals would have fallen below 1000 at the beginning of July. If restrictions had been lifted completely on April 20, the number of sick should have risen quickly again from around 27 April. A balance between economic and individual costs of RSC and…

medicine.medical_specialty2019-20 coronavirus outbreakEconomics and EconometricsCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Geography Planning and Developmentforecast Germanyepidemic03 medical and health sciences0302 clinical medicine0502 economics and businessPandemicmedicine030212 general & internal medicineChromatin structure remodeling (RSC) complex050207 economicsExit strategybiologyI18SARS-CoV-2Public healthJel/E17pandemic05 social sciencesE17Jel/I18ArticlesEconomic benefitsEditor's ChoiceC63biology.proteinDemographic economicsJel/C63BusinessCovid-19Cesifo Economic Studies
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Should contact bans be lifted in Germany? A quantitative prediction of its effects

2020

Many countries consider the lifting of restrictions of social contacts (RSC). We quantify the effects of RSC for Germany. We initially employ a purely statistical approach to predicting prevalence of COVID19 if RSC were upheld after April 20. We employ these findings and feed them into our theoretical model. We find that the peak of the number of sick individuals would be reached already mid April. The number of sick individuals would fall below 1,000 at the beginning of July. When restrictions are lifted completely on April 20, the number of sick should rise quickly again from around April 27. A balance between economic and individual costs of RSC and public health objectives consists in l…

medicine.medical_specialtyExit strategyBalance (accounting)Coronavirus disease 2019 (COVID-19)biologyPublic healthmedicinebiology.proteinDemographic economicsBusinessChromatin structure remodeling (RSC) complexEconomic benefits
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