Search results for "chronic"

Piclamilast inhibits the pro-apoptotic and anti-proliferative responses of A549 cells exposed to H(2)O(2) via mechanisms involving AP-1 activation.

2012

Reactive oxygen species (ROS) are involved in the pathogenesis of many inflammatory diseases such as chronic obstructive pulmonary disease (COPD). They can alter the expression of genes involved in cellular damage by activating transcription factors, including the NF-κB and the activator protein 1 (AP-1). Phosphodiesterase type 4 (PDE4) inhibitors have anti-inflammatory and antioxidant effects, as described in in vivo and in vitro COPD models. This study analysed the effects of piclamilast, a selective PDE4 inhibitor, on modulating the global gene expression profile in A549 cells exposed to H(2)O(2).Changes in gene expression were analysed using high-density Affymetrix microarrays and valid…

Intervención psicológica en la adhesion al tratamiento de enfermedades crónicas pediátricas

2001

El presente trabajo analiza desde el punto de vista psicológico los problemas de cumplimiento del tratamiento en las enfermedades crónicas pediátricas. Se describe la repercusión del tema sobre la enfermedad, el médico responsable, el paciente y sus familiares, haciendo una mención especial a la complejidad del problema cuando se presenta en la población adolescente. Se revisan los factores que dificultan la adherencia a las prescripciones médicas, identificando aspectos relacionados con la enferm edad y el tratamiento, y variables cognitivas, emocionales, conductuales, familiares, sociales, culturales, organizacionales y económicas. Se realiza una propuesta de intervención psicológica que …

Revising the negative meaning of chronic pain – a phenomenological study

2016

The essence of the experience of chronic pain – a phenomenological study

2016

Revising the negative meaning of chronic pain : A phenomenological study

2014

Objectives Chronic pain may disable the body, depress the mind and ruin the quality of life. The aim of this study was to use the participants’ personal experiences to explore the meaning of the experience of chronic pain and to find successful ways to manage chronic pain. Methods Thirty-four participants with chronic pain were interviewed. The transcribed interviews were analysed using Giorgi’s phenomenological method consisting of four phases: (1) reading the transcriptions several times, (2) discriminating meaning units, (3) collecting meaning units into groups and (4) the synthesis. Results The participants stated that the key to managing chronic pain was to reconsider the individual me…

How to measure sustained psychic transformations in long-term treatments of chronically depressed patients: Symptomatic and structural changes in the…

2019

Worldwide, the pressure on psychoanalysis to prove the results of its treatments according to the criteria of so-called evidence-based medicine has increased. While a large number of studies on the results of psychoanalytic short-term therapies are now available, such studies are still largely lacking on psychoanalysis and psychoanalytic long-term therapies. In a large multicentre study, the results of psychoanalytical and cognitive-behavioural longterm therapies in chronically depressed patients were compared, Both psychotherapies led to statistically highly significant changes in depressive symptoms three years after the start of the treatments However, the focus of psychoanalytic treatme…

“Selling” chronic pain: physiotherapists’ lived experiences of communicating the diagnosis of chronic nonspecific lower back pain to their patients

2019

Introduction: Chronic nonspecific lower back pain (CNSLBP) is a common musculoskeletal condition which can be a source of significant distress and disability for patients. Approaches to managing CNSLBP have been explored in healthcare literature, as has the importance of communication in physiotherapy practice. However, no previous studies have explored clinicians’ experiences of communicating their understanding of this diagnosis to their patients. Methods: A qualitative research design, using hermeneutic phenomenological methodology, was employed. Five participants were purposively recruited for the research and data collected via semi-structured interviews. Interpretative phenomenologica…

Stratégies d’adaptation face à la douleur chronique

2017

Chronic pain constitutes a challenge for patients. It makes them uneasy with regard to their personality, their corporality and their life balance, and leaves long-lasting effects on their experience as a patient. The development of adaptation strategies and resources to deal with chronic pain is therefore essential.

Chronic pain management in non-oncologic patients: multicentric study on adult patients referring to the centers for pain management in the Lazio Reg…

2013

Introduction Chronic pain is a complex phenomenon usually associated with psychological stress, which implies falling back on the National Health Service and reducing work capacities, indeed affecting Activities of Daily Living. Studies based on efficacy have identified the multidisciplinary approach as the most effective means to obtain therapeutic results. These programs can be provided by the Centers for Pain Management (CPMs), where multidisciplinary teams are likely to provide the necessary expertise to outline the best treatments for the diagnosis and management of chronic pain. To date, very little information is available on the kind of assistance and support these centers can provi…

Long-term residential exposure to air pollution and risk of chronic respiratory diseases in Italy: The BIGEPI study

2023

: Long-term exposure to air pollution has adverse respiratory health effects. We investigated the cross-sectional relationship between residential exposure to air pollutants and the risk of suffering from chronic respiratory diseases in some Italian cities. In the BIGEPI project, we harmonised questionnaire data from two population-based studies conducted in 2007-2014. By combining self-reported diagnoses, symptoms and medication use, we identified cases of rhinitis (n = 965), asthma (n = 328), chronic bronchitis/chronic obstructive pulmonary disease (CB/COPD, n = 469), and controls (n = 2380) belonging to 13 cohorts from 8 Italian cities (Pavia, Turin, Verona, Terni, Pisa, Ancona, Palermo,…