Search results for "chronic"
showing 9 items of 3309 documents
[Optimization of systemic treatments for chronic plaque psoriasis. Recommendations for switching and transitioning.]
2014
The aim of this study was to provide practical recommendations for optimizing the use of conventional and biological systemic treatments for moderate-severe chronic plaque psoriasis, particularly in case of transitioning and switching.A total number of 147 dermatologists from 33 different countries including Italy achieved consensus in providing practical recommendations for the use of conventional and biological treatments for moderate to severe psoriasis based on systematic literature review and/or expert opinion.In general, the continuous treatment regimen should be preferred in order to achieve a complete and long-term control of psoriasis. However, the treatment could be stopped or the…
Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity.
2022
Immune cells undergo different metabolic pathways or immunometabolisms to interact with various antigens. Immunometabolism links immunological and metabolic processes and is critical for innate and adaptive immunity. Although metabolic reprogramming is necessary for cell differentiation and proliferation, it may mediate the imbalance of immune homeostasis, leading to the pathogenesis and development of some diseases, such as autoimmune diseases. Here, we discuss the effects of metabolic changes in autoimmune diseases, exerted by the leading actors of innate immunity, and their role in autoimmunity pathogenesis, suggesting many immunotherapeutic approaches.
The CANNA-TICS Study Protocol: A Randomized Multi-Center Double-Blind Placebo Controlled Trial to Demonstrate the Efficacy and Safety of Nabiximols i…
2020
Background: Gilles de la Tourette syndrome (TS) is a chronic neuropsychiatric disorder characterized by motor and vocal tics. First-line treatments for tics are antipsychotics and tic-specific behavioral therapies. However, due to a lack of trained therapists and adverse events of antipsychotic medication many patients seek alternative treatment options including cannabis. Based on the favorable results obtained from case studies on different cannabis-based medicines as well as two small randomized controlled trials using delta-9-tetrahydrocannabinol (THC), we hypothesize that the cannabis extract nabiximols can be regarded as a promising new and safe treatment strategy in TS.Objective: To …
EXTRACORPOREAL SHOCK WAVE THERAPY (ESWT) IN CHRONIC LOW BACK PAIN: A SYSTEMATIC REVIEW OF RANDOMIZED CLINICAL TRIALS
2020
Background: Extracorporeal Shock Wave Therapy (ESWT) has become a popular tool to treat musculoskeletal disorders and chronic low back pain. Aim of the study: To review the current scientific literature and assess the utility of ESWT in treating chronic low back pain. Methods: This systematic review was conducted from November 2019 to January 2020. Its purpose was to determine what the effectiveness is of the various forms of ESWT for the treatment of chronic low back pain. The critical review of the literature on the use of ESWT in chronic low back was made using the scientifically recognized medical databases PubMed, MEDLINE, Physiotherapy Evidence Database (PEDro) and Web of Science Core…
Denying the Truth Does Not Change the Facts: A Systematic Analysis of Pseudoscientific Denial of Complex Regional Pain Syndrome
2021
Purpose Several articles have claimed that complex regional pain syndrome (CRPS) does not exist. Although a minority view, it is important to understand the arguments presented in these articles. We conducted a systematic literature search to evaluate the methodological quality of articles that claim CRPS does not exist. We then examined and refuted the arguments supporting this claim using up-to-date scientific literature on CRPS. Methods A systematic search was conducted in MEDLINE, EMBASE and Cochrane CENTRAL databases. Inclusion criteria for articles were (a) a claim made that CRPS does not exist or that CRPS is not a distinct diagnostic entity and (b) support of these claims with subse…
Characteristics of being hospitalized as a child with a new diagnosis of type 1 diabetes: a phenomenological study of children’s past and present exp…
2015
Background: Our understanding of children and childhood has changed over the last few decades, which may have an impact on children’s conditions in hospitals. Children’s rights have been strengthened by the “Convention on the Rights of the Child” and ward regulations. The aim of this Norwegian study was to identify potential characteristics of children's lived experience of being hospitalized diagnosed with type 1 diabetes today and from a retrospective view in the period 1950–1980, despite the many obvious external changes. Methods: This study presents a further analysis of data from two previous phenomenological studies. The first had a retrospective perspective, and the second assumed a …
Parents’ experiences of the transfer from pediatric to adult care for their adolescent or young adult children with chronic conditions: a systematic …
2014
Published version of an article in the journal: JBI Database of Systematic Reviews and Implementation Reports. Also available from the publisher at: http://dx.doi.org/10.11124/jbisrir-2014-1565 Open Access Review question/objective: The objective of this systematic review is to identify parents' experiences of adolescents and young adults (AYA) health care transfer from pediatric to adult care. 1. How do parents experience being prepared for the transfer from pediatric to adult care of their AYA with a chronic condition? 2. How do parents experience the event of transfer? 3. How does the type of chronic condition influence parents' experiences of AYAs' transfer from pediatric to adult care?…
Zadania pielęgniarki rodzinnej w opiece nad chorym z przewlekłą chorobą układu krążenia
2016
Wstęp: Do najczęstszych chorób przewlekłych w Polsce i na świecie nadal należą choroby układu krążenia, które mimo prowadzonych działań profilaktycznych, stanowią główną przyczynę śmierci. Istotną rolę w opiece pozaszpitalnej nad pacjentami z przewlekłymi chorobami układu krążenia odgrywają pielęgniarki rodzinne. Wchodzą w skład zespołu terapeutycznego podstawowej opieki zdrowotnej, sprawującego kompleksową opiekę nad pacjentem. Do kompetencji pielęgniarek rodzinnych należy m.in.: samodzielne diagnozowanie, planowanie oraz realizacja opieki pielęgniarskiej. Pielęgniarki rodzinne są również źródłem informacji dla chorego, wypełniają zadania pielęgnacyjne, terapeutyczne, diagnostyczne, a takż…
Monotherapy with indacaterol once daily reduces the rate of exacerbations in patients with moderate-to-severe COPD: Post-hoc pooled analysis of 6 mon…
2014
Summary Background In patients with COPD, exacerbations are associated with poor quality of life and may shorten survival. Prevention of exacerbations is, therefore, a key objective in COPD management. Indacaterol, a once-daily ultra-long-acting β 2 -agonist, has been shown to reduce exacerbations in various studies. This pooled analysis evaluated the effect of indacaterol on exacerbations versus placebo. Methods Six-month data were pooled from three randomized, double-blind, and placebo-controlled studies: indacaterol 300 μg versus placebo (1 year); indacaterol 150 μg and 300 μg versus placebo (6 months); and indacaterol 150 μg versus placebo (6 months). All treatments were administered on…