Search results for "chronic"
showing 10 items of 3309 documents
Assessing covariate imbalance in meta-analysis studies.
2010
The main goal of meta-analysis is to combine data across studies or data sets to obtain summary estimates. In this paper, the novelty is to propose a statistical tool to assess a possible covariate imbalance in baseline variables to investigate similarity of trials. We conducted the detection of the covariate imbalance, first, through some graphical comparison of the empirical cumulative distribution functions or ECDFs, which are built by putting together arms or trials according to some risk factor, and second, through some non-parametric tests such as the Kolmogorov–Smirnov and the Anderson–Darling tests. To overcome the huge presence of ties, we conducted the statistical tests on perturbe…
Estimating regression models with unknown break-points.
2003
This paper deals with fitting piecewise terms in regression models where one or more break-points are true parameters of the model. For estimation, a simple linearization technique is called for, taking advantage of the linear formulation of the problem. As a result, the method is suitable for any regression model with linear predictor and so current software can be used; threshold modelling as function of explanatory variables is also allowed. Differences between the other procedures available are shown and relative merits discussed. Simulations and two examples are presented to illustrate the method.
Synthesis and in vitro antileukemic activity of new 4-triazenopyrazole derivatives
2003
Several new 4-(3,3-dimethyltriazeno)-5-benzamidopyrazole derivatives were prepared by reacting 4-diazo-5-benzamidopyrazole derivatives with dimethylamine. The compounds were tested at 10 microM for their vitro antileukemic activity against K562 (Human chronic myelogenous leukemia) and Raji (human Burkitt limphoma ) cell lines. Dacarbazine and methotrexate were used for comparative purpose. The 3-methyl-4-(3,3-dimethyltriazeno)-5-(substituted benzamido)pyrazoles, bearing the pyrazole nucleus free at 1 position, resulted more active than the 1-(substituted phenyl)-3-methyl-4-(3,3-dimethyltriazeno)-5-benzamidopyrazoles. Dacarbazine at 10 microM showed no activity in the above tests. The observ…
Unveiling the Ionic Diels-Alder Reactions within the Molecular Electron Density Theory
2021
The ionic Diels–Alder (I-DA) reactions of a series of six iminium cations with cyclopentadiene have been studied within the Molecular Electron Density Theory (MEDT). The superelectrophilic character of iminium cations, ω >
The Role of Medical Humanities in Prevention and Treatment of Patients with Chronic Diseases
2023
In the field of prevention and treatment of patients with chronic diseases, biomedicine often shows its inability to be effective on a clinical level, despite its extraordinary scientifical growth. Through the analysis of a clinical vignette, the paper illustrates the skills and the solutions that could be applied to obtain awareness and compliance in chronic patients, using the expertise we can obtain from Medical Humanities.
Type-I interferons are potent inhibitors of interleukin-8 production in hematopoietic and bone marrow stromal cells
1993
Abstract nterleukin-8 (IL-8) is produced by many cell types upon stimulation with bacterial products or inflammation-associated cytokines such as tumor necrosis factor-alpha and IL-1. Interferons (IFNs) represent another group of cytokines that are induced by similar stimuli in inflammatory reactions. We show now that type-I IFNs are potent inhibitors of IL-8 expression in vitro and in vivo. A significant reduction of both secretion of IL-8 protein and accumulation of IL-8 mRNA in vitro was observed in several cell types comprising peripheral blood mononuclear cells (PBMNC) from healthy donors and from patients with chronic myelogenous leukemia (CML), the myelomonocytic cell line THP-1, and…
Update on mechanism and therapeutic implications of spinal cord stimulation and cerebral hemodynamics: A narrative review
2017
Spinal cord stimulation (SCS) is well known for its early role in the management of chronic pain, mainly failed back surgery syndrome (FBSS), spasticity, and bowel and bladder dysfunction. In more recent years, SCS has been proposed for patients suffering from refractory angina or peripheral vasculopathies in order to gain symptom relief, thus indicating some hemodynamic effect on the peripheral circulation. Taking into account this scientific observation, since the late1980s, researchers have started to investigate the potential effect of SCS on cerebral blood flow (CBF) regulation and its possible application in certain pathological settings dealing with vascular pattern dysfunction, such…
Temporality of Maternity, Chronic Pain, and Ethics: Challenging Current Narratives on Pain and Health
2021
This chapter aims to articulate new ethical possibilities made apparent during experiences of chronic pain, and suggest an ethics of temporality apparent in the mother–child relation. I also aim to bring an understanding of the complexity and diversity of subjectivities in pain and its impact on its social, intersubjective environment. The narratives of mothers who have experienced chronic pain for more than three months help articulate a gap found in the Western model of medical knowledge. I hope to shift attention from the perspective of a patient understood as an objectified object of pain and from pain as a separate object of study to a study of the concrete embodied experiences of moth…
Measuring Muscle Fatigue in Relation to the Workload of Health Care Workers
2015
Abstract Number of work related musculoskeletal disorders due to ergonomics risks among workers in Europe, including Latvia, is growing. Employees in health care professions admit physical load and discomfort in various body parts after the shift. According to Eurostat statistical data 60% of total work related diseases are attributed to musculoskeletal disorders in Latvia. The aim of this study was to determine the muscle fatigue caused by physical load for surgeons, anaesthetists and geneticists in one of the largest Hospitals in Latvia. The research involved 9 surgeons, 9 anaesthetists and 7 geneticists with chronic pain (for four months or more) in the neck, shoulders, arms, hands and l…
Results of isolated posterolateral corner reconstruction
2010
Abstract Background Isolated posterolateral corner (PLC) tears are relatively rare events. Various surgical techniques to treat posterolateral knee instability have been described; because surgical results are linked to cruciate reconstructions it has been difficult to date to define whether one surgical procedure has better prognosis than another. The goal of this study is to determine the clinical outcome of PLC reconstruction following fibular-based technique. Materials and methods We retrospectively evaluated a case series of patients who received isolated PLC reconstruction between March 2005 and January 2007. Ten patients were surgically treated for isolated injuries and were availabl…