Search results for "circular"

Flow measurement using circular portable flume

2018

Abstract The circular portable flume is a simple device to measure discharge in circular drainage networks. Since the unit can be easily installed and removed, it is helpful in water distribution measurement and management. First in this paper the available studies are reviewed for highlighting the effect of both the contraction ratio and the flume slope on the stage-discharge relationship. Then the Buckingham's Theorem of the dimensional analysis and the self-similarity theory are used to deduce the stage-discharge curve of the circular flume. The new theoretical stage-discharge equation is calibrated by the literature available experimental data and those obtained in this experimental inv…

Aircraft wing rock oscillations suppression by simple adaptive control

2020

Abstract Roll angular motion of the modern aircraft operating in non-linear flight modes with a high angle of attack often demonstrates the limit cycle oscillations, which is commonly known as the wing rock phenomenon. Wing rock dynamics are represented by a substantially non-linear model, with parameters varying over a wide range, depending on the flight conditions (altitude, Mach number, payload mass, etc.) and angle of attack. A perspective approach of the wing rock suppression lies in the adaptation methods. In the present paper an application of the simple adaptive control approach with the Implicit Reference Model (IRM) is proposed and numerically studied. The IRM adaptive controller …

Geometrical deviation of end-of-life parts as a consequence of reshaping by single point incremental forming

2021

AbstractPutting in place circular economy strategies is an urgent challenge to face. In this scenario, manufacturing processes play a relevant role as efficient material reuse enabler. Scientists have to make an effort either to find new process or to rethink old process to reprocess end-of-life (EoL) component to recover both material and functions. In this paper, single point incremental forming (SPIF) process is used for reshaping sheet metal EoL components. The entire process chain was replicated including both deep drawing process (to imitate the end-of-life component) as well as SPIF operations (to obtain the reshaped components). The geometrical deviation as a consequence of SPIF ope…

Manufacturing processes as material and energy efficiency strategies enablers: The case of Single Point Incremental Forming to reshape end-of-life me…

2021

Abstract Making materials consumes about 21% of the global energy demand; concerning metals production, it accounts for about 8% of total global energy consumption. Circular economy strategies such as longer life, more intense use, repair, product upgrades, modularity, remanufacturing, component reuse, and open/closed-loop recycling are strategies to put in place urgently to reduce the environmental impact of raw material production. Although recycling of metals is the most used strategy and is being improved in terms of efficiency, it is mandatory moving towards more virtuous circular economy strategies, such as product/component reuse. In this paper a novel reuse strategy for sheet metal …

Manufacturing strategies for efficiency in energy and resources use: The role of metal shaping processes

2017

Abstract Manufacturing sector nowadays has to deal with the global need to reduce the environmental impact of human activity. As manufacturing accounts for a significant portion of the global CO 2 emissions, scientific research should be addressed to understand the environmental impact of manufacturing processes and, in the meantime, to take advantage of their full potential in reducing the overall CO 2 emissions. The present review paper aims at describing the role of metal shaping processes in reducing the environmental impact across different stages of metal components life. Actually, an increased consciousness concerning both the environmental performances of manufacturing processes and…

Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.

2018

Summary Metastasis is the primary cause of death of cancer patients. Dissecting mechanisms governing metastatic spread may uncover important tumor biology and/or yield promising therapeutic insights. Here, we investigated the role of circular RNAs (circRNA) in metastasis, using melanoma as a model aggressive tumor. We identified silencing of cerebellar degeneration-related 1 antisense (CDR1as), a regulator of miR-7, as a hallmark of melanoma progression. CDR1as depletion results from epigenetic silencing of LINC00632, its originating long non-coding RNA (lncRNA) and promotes invasion in vitro and metastasis in vivo through a miR-7-independent, IGF2BP3-mediated mechanism. Moreover, CDR1as le…

Ethanol Controls the Self-Assembly and Mesoscopic Properties of Human Insulin Amyloid Spherulites.

2018

Protein self-assembly into amyloid fibrils or highly hierarchical superstructures is closely linked to neurodegenerative pathologies as Alzheimer's and Parkinson's diseases. Moreover, protein assemblies also emerged as building blocks for bioinspired nanostructured materials. In both the above mentioned fields, the main challenge is to control the growth and properties of the final protein structure. This relies on a more fundamental understanding of how interactions between proteins can determine structures and functions of biomolecular aggregates. Here, we identify a striking effect of the hydration of the single human insulin molecule and solvent properties in controlling hydrophobicity/…

Study of interaction of antimutagenic 1,4-dihydropyridine AV-153-Na with DNA-damaging molecules and its impact on DNA repair activity

2018

Background1,4-dihydropyridines (1,4-DHP) possesses important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. It was shown that the antimutagenic 1,4-dihydropyridine AV-153-Na interacts with DNA. The aim of the current study was to test the capability of the compound to scavenge peroxynitrite and hydroxyl radical, to test intracellular distribution of the compound, and to assess the ability of the compound to modify the activity of DNA repair enzymes and to protect the DNA in living cells against peroxynitrite-induced damage.MethodsPeroxynitrite decomposition was assayed by UV spectroscopy, hydroxyl radical scavenging—by EPR spectroscopy. DNA b…

2019

The DNA-binding of the natural benzophenanthridine alkaloid chelerythrine (CHE) has been assessed by combining molecular modeling and optical absorption spectroscopy. Specifically, both double-helical (B-DNA) and G-quadruplex sequences—representative of different topologies and possessing biological relevance, such as telomeric or regulatory sequences—have been considered. An original multiscale protocol, making use of molecular dynamics (MD) simulations and quantum mechanics/molecular mechanics (QM/MM) calculations, allowed us to compare the theoretical and experimental circular dichroism spectra of the different DNA topologies, readily providing atomic-level details of the CHE–DNA binding…

Secondary structure and dynamics study of the intrinsically disordered silica-mineralizing peptide P5S3during silicic acid condensation and silica de…

2017

The silica forming repeat R5 of sil1 from Cylindrotheca fusiformis was the blueprint for the design of P5 S3 , a 50-residue peptide which can be produced in large amounts by recombinant bacterial expression. It contains 5 protein kinase A target sites and is highly cationic due to 10 lysine and 10 arginine residues. In the presence of supersaturated orthosilicic acid P5 S3 enhances silica-formation whereas it retards the dissolution of amorphous silica (SiO2 ) at globally undersaturated concentrations. The secondary structure of P5 S3 during these 2 processes was studied by circular dichroism (CD) spectroscopy, complemented by nuclear magnetic resonance (NMR) spectroscopy of the peptide in …