Search results for "coagulation"

Studies on mechanism and physico-chemical parameters at the origin of the cement setting II. Physico-chemical parameters determining the coagulation …

1996

The physico-chemical parameters determining the coagulation of cements grains previously identified as the first fundamental process of cement setting have been investigated in diluted suspensions using an adapted granulometric method. The analysis of the influence of the ionic concentration in solution on the coagulation reveals that calcium concentration is the parameter which determines the particle interactions. There exists a minimum critical concentration of calcium ions in solution which is required to occur the coagulation of cement particles and a dispersive effect appears for very high concentrations. The results are discussed in relation with DLVO theory and specific interactions.

Physico-chemical parameters determining hydration and particle interactions during the setting of silicate cements

1997

Abstract Hydration of tricalcium silicate (Ca 3 SiO 5 ), the pure phase used as a model of the portland cements, is the chemical process leading to the formation of hydrates, while setting is a definite time event corresponding to the change of the paste from the soft to the hard state. Setting results from interactions between anhydrous or very partially hydrated particles. The analysis of these interactions leads to the identification of two fundamental steps: the coagulation of cement grains during the first minutes following the mixing and the rigidification of the coagulated structure which arises simultaneously with the acceleration of the calcium silicate hydrates (CSH) formation. …

Interaction of inflammation, thrombosis, aspirin and enoxaparin in CNS experimental antiphospholipid syndrome

2008

Experimental antiphospholipid syndrome (eAPS) induced by immunization with beta(2)-glycoprotein I (beta(2)-GPI) causes behavioral hyperactivity. We assessed the role of thrombotic and inflammatory perivascular factors and standard APS therapies for CNS manifestations. Groups of mice (n=10 per group) were immunized once with beta(2)-GPI (eAPS) or adjuvant (controls) and treated daily from 1 month after immunization with either sham injections, aspirin (1.2 mg/kg) or enoxaparin (1 mg/kg) for 3 months. Serum antiphospholipid antibodies (aPL) and brain levels of tissue necrosis factor-alpha (TNF-alpha) and prostaglandin E (PGE) were then measured by ELISA and thrombin inhibitors by immunoblot. …

Interactions between chemical evolution (hydration) and physical evolution (setting) in the case of tricalcium silicate

1994

This paper describes recent experimental results concerning investigation of the parameters which determine, on the one hand, the kinetics of hydration of tricalcium silicate and the thermodynamic, morphological and structural characteristics of C-S-H and, on the other hand, the evolution of the particle interactions at the origin of setting. It is shown that, in both cases, lime concentration in solution is the most important parameter. As a consequence, the chemical evolution of the system, which controls the lime concentration in solution, determines the nature of particle interactions and the physical evolution of the suspension or paste. In return, the contacts, between particles, resu…

Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids

2021

Platelet proteome analysis reveals an early hyperactive phenotype in SARS-CoV-2-infected humanized ACE2 mice

2021

AbstractCoronavirus disease-2019 (COVID-19) provokes a hypercoagulable state with increased incidence of thromboembolism and mortality. Platelets are major effectors of thrombosis and hemostasis. Suitable animal models are needed to better understand COVID-19-associated coagulopathy (CAC) and underlying platelet phenotypes. Here, we assessed K18-hACE2 mice undergoing a standardized SARS-CoV-2 infection protocol to study dynamic platelet responses via mass spectrometry-based proteomics. In total, we found significant changes in >1,200 proteins. Strikingly, protein alterations occurred rapidly by 2 days post-infection (dpi) and preceded outward clinical signs of severe disease. Pathway enr…

ProC Global: the first functional screening assay for the complete protein C pathway.

1997

Abstract In clinical practice, venous thromboembolic complications are much more frequent than bleeding disorders. In fact, disturbances within the protein C pathway due to coagulation factor V (FV) Leiden mutation and deficiency of protein C or protein S are the most frequent abnormalities in hereditary thrombophilia. Furthermore, acquired dysfunctions of the protein C system may predispose the single individual to an increased thrombotic risk. A routine-suited screening assay that would allow the monitoring of the proper interplay of factors in the protein C pathway could add an important factor to the basic coagulation profile. This consists of the prothrombin time and of the activated p…

Endovascular treatment of chronic cerebro spinal venous insufficiency in patients with multiple sclerosis modifies circulating markers of endothelial…

2014

Coagulation and fibrinolysis

2016

L’IMPIEGO CLINICO DI UNA NUOVA CLASSE DI FARMACI ANTICOAGULANTI: GLI INIBITORI DIRETTI DELLA TROMBINA

2006

The coagulation cascade, and particularly thrombin, plays a very important role in arterial and venous thrombosis. Thereby, it is clear that thrombin inactivation is an optimal strategy for thrombotic disease prevention and treatment. The direct thrombin inhibitors are a new class of anticoagulant drugs directly binding thrombin and blocking its interaction with fibrinogen. The group of direct thrombin inhibitors includes recombinant hirudin (lepirudin and desirudin), bivalirudin, melagatran and its oral precursor, ximelagatran, argotraban and dabigatran. These drugs have several advantages compared to other anticoagulant drugs, and the particular pharmacokinetic properties of some of them …