Search results for "coca"
showing 10 items of 231 documents
Determinación de cocaína por espectrometría vibracional
2017
RESUMEN DE LA TESIS DOCTORAL Clara María Pérez Alfonso. DETERMINACIÓN DE COCAÍNA POR ESPECTROMETRÍA VIBRACIONAL. Universitat de València. La cocaína es una sustancia con actividad anestésica y psicoactiva que se obtiene a partir de la hoja de la planta de la coca (Erythroxylon coca o Erythroxylon novogranatense). Esta sustancia es responsable de gran parte de los casos de hospitalización por problemas agudos y muertes relacionadas con el consumo de drogas en Europa. Es la droga de abuso objeto de mayor número de incautaciones después de la planta de cannabis y el hachis, la que se encuentra en matrices más variadas y la que sufre mayor adulteración de todas las sustancias ilegales que se an…
The effects of the tricyclic antidepressants desipramine, doxepin and iprindole on the isolated perfused rabbit heart.
1974
1. The right sympathetic nerves of isolated perfused rabbit hearts were stimulated electrically (1 msec, supramaximal strength, 15 sec) with increasing frequencies (0.25–20 Hz) at 3 min intervals before and 20 min after starting perfusion with desipramine, doxepin or iprindole. Ventricular rate, right atrial and right ventricular tensions were recorded using the transverse method. 2. Sympathic nerve stimulation caused ventricular arrhythmias in the presence of desipramine (3.3 and 5.0 · 10−6 M) and doxepin (1.6−4.7×10−6 M) but failed to produce arrhythmias in hearts not exposed to drugs, or after iprindole, cocaine and atropine. 3. When desipramine or doxepin was added to Tyrode solution co…
Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation
2020
The prepulse inhibition (PPI) of the startle response can identify the rodents that are more sensitive to the effects of cocaine. Mice with a lower PPI presented a higher vulnerability to the effects of cocaine and a higher susceptibility to developing a substance use disorder (SUD). Maternal separation with early weaning (MSEW) is a relevant animal model to induce motivational alterations throughout life. Nevertheless, only a few studies on females exist, even though they are more vulnerable to stress- and cocaine-related problems. Hence, the aim of the present study was to evaluate the ability of PPI to identify females with a greater vulnerability to the long-term consequences of early s…
Spatio‐temporal assessment of illicit drug use at large scale : evidence from 7 years of international wastewater monitoring
2019
Background and aims Wastewater‐based epidemiology is an additional indicator of drug use that is gaining reliability to complement the current established panel of indicators. The aims of this study were to: (i) assess spatial and temporal trends of population‐normalized mass loads of benzoylecgonine, amphetamine, methamphetamine and 3,4‐methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011–17); (ii) address overall drug use by estimating the average number of combined doses consumed per day in each city; and (iii) compare these with existing prevalence and seizure data. Design Analysis of daily raw wastewater composite samples collected over 1 week per year from 2011 to…
A PLE-based resolution of cocaine, pseudococaine, and 6- and 7-methoxylated cocaine analogues
1996
Abstract The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.
Vittorio Emanuele Orlando, Santi Romano e Franco Gaetano Scoca
2020
The paper focuses, firstly, on relationship between Vittorio Emanuele Orlando and Santi Romano,to then highlight how Franco Gaetano Scoca can be considered a legitimate scientific heir of these patres
I Cretesi in Sicilia: la proiezione culturale
2011
Si prendono in esame le tradizioni letterarie sul mito di Minosse, Dedalo e Cocalo, mettendole in relazione con le notizie sulla fondazione di Gela. il mito non presenta una marcata valenza identitaria, e non pertanto non può essere inteso come uno strumento utilizzato univocamente dai coloni di origine cretese per rivendicare la preminenza del loro ruolo, rispetto al gruppo di origine rodia, nelle fondazioni coloniali di Sicilia. Le tradizioni mitiche sono state sfruttate da entrambi i gruppi coloniali per proiettare nello sfondo delle vicende eroiche il modello delle relazioni interetniche che si volevano instaurare nell'attualità con le popolazioni non greche di Sicilia gravitanti attorn…
Effects of a short-term hypoenergetic diet on morphofunctional left ventricular parameters in centrally obese subjects
2000
BACKGROUND: We aimed to study centrally obese subjects without other diseases, to establish whether a short-term hypoenergetic balanced regimen is able to positively modify left ventricular (LV) patterns. METHODS: We studied 32 obese subjects (out of 52 recruited for this study) with central fat distribution and without associated diseases. Each subject had undergone a moderately hypoenergetic diet for a four-month follow-up period and had a regular loss in weight. Some relevant clinical and echocardiographic parameters were evaluated. Baseline data and those evaluated at the end of the follow-up period were used for outcome analysis. RESULTS: We found a considerable reduction in LV mass an…
STATISTICS OF DATA RELATED TO AMAZING SUBSTANCES ANALYZED AT THE “LABORATORY OF CHEMICAL INVESTIGATIONS” OF THE PALERMO SCIENTIFIC POLICE
2019
The substances analyzed mainly at the “Chemical Investigation Laboratory” of the Regional Cabinet of Palermo, in the period from 2013 to 2018, are heroin and cocaine. For analytical techniques, mass spectrometry techniques associated with gas chromatography were used. Statistical analysis revealed a general increase in both the distribution and the average percentage of active ingredient in heroin, a substance currently available on the illicit market at a lower price than in the past, often cut with substances of synthetic derivation.Comparison of heroin seizure data in western Sicily and throughout the national territory shows a growth trend; in particular, in 2017 there is an average per…
Cocaine addiction and personality: a mathematical model.
2010
The existence of a close relation between personality and drug consumption is recognized, but the corresponding causal connection is not well known. Neither is it well known whether personality exercises an influence predominantly at the beginning and development of addiction, nor whether drug consumption produces changes in personality. This paper presents a dynamic mathematical model of personality and addiction based on the unique personality trait theory (UPTT) and the general modelling methodology. This model attempts to integrate personality, the acute effect of drugs, and addiction. The UPTT states the existence of a unique trait of personality called extraversion, understood as a di…