Search results for "coca"
showing 10 items of 231 documents
'Magnetic Stimulation in the treatment of Addiction'
Efectos a largo plazo de la exposición al alcohol y a la cocaína durante la adolescencia en modelos animales: factores de riesgo y posibles tratamien…
2016
El primer contacto con las drogas se produce mayoritariamente en la adolescencia, pero la transición del uso voluntario a la dependencia, desarrollando un trastorno por el uso de sustancias, solo se manifiesta en un cierto porcentaje de individuos. El presente trabajo evalúa la influencia que a largo plazo presentan ciertas variables ambientales, individuales y biológicas durante la adolescencia, sobre la vulnerabilidad a los efectos reforzantes de la cocaína y su nivel de consumo en sujetos adultos. Concretamente, hemos comprobado cómo la exposición durante la adolescencia al alcohol o cocaína en forma de binge, el nivel del rasgo de personalidad de búsqueda de la novedad, o la pertenencia…
The Peroxisome Proliferator WY-14,643 Promotes Hepatocarcinogenesis Caused by Endogenously Generated Oxidative DNA Base Modifications in Repair-Defic…
2007
Abstract Basal levels of endogenously generated oxidative DNA modifications such as 7,8-dihydro-8-oxoguanine (8-oxoG) are present in apparently all mammalian cells, but their relevance for the generation of spontaneous cancers remains to be established. Both the 8-oxoG levels and the resulting spontaneous mutations are increased in the livers of Csbm/m/Ogg1−/− mice, which are deficient in the repair of 8-oxoG. In order to determine the consequences of these additional oxidative DNA modifications and mutations and thus assess the tumor initiating potency of this type of endogenous DNA damage, we treated Csbm/m/Ogg1−/− mice and repair-proficient controls with the peroxisome proliferator WY-14…
Polychlorinated biphenyls, classified as either phenobarbital- or 3-methylcholanthrene-type inducers of cytochrome P-450, are both hepatic tumor prom…
1986
Abstract The cytochrome P -450 isozymes, cytochrome P -450 MC 1 and MC 2 , purified from rats treated with 3-methylcholanthrene (MC), were found by immunohistochemical staining to be strongly induced in the livers of rats treated with 3,3′, 4,4′-tetrachlorobiphenyl (TCBP), while the cytochrome P -450 isozymes, PB 1 and PB 2 , purified from the livers of rats treated with phenobarbital (PB), were shown to be induced in the livers of rats treated with 2,2′, 4,4′, 5,5′-hexachlorobiphenyl (HCBP). The latter compound also strongly induced NADPH-cytochrome P -450-reductase. Following induction, all 5 enzymes were located preferentially in the centrilobular and midzonal region of the liver acinus.…
Molecularly imprinted polymer-based device for field collection of oral fluid samples for cocaine identification.
2020
In this paper, a low-cost, rapid, easy, and potentially portable tool for the identification of cocaine and its semi-quantitative determination in oral fluid has been proposed. A field collection device has been designed, based on a cotton pad with an indicator and a molecularly imprinted polymer (MIP) sorbent, to selective retain cocaine from oral fluid components. After sample collection, cocaine is transferred by using phosphate buffer to the MIP and then eluted with 2-propanol. The obtained extract is analysed by ion mobility spectrometry (IMS), providing a cut-off value of 20 µg L-1 that identifies 100 % true-positive and 95 % true-negative samples. The MIP-IMS procedure has been valid…
Atropine-resistant effects of the muscarinic agonists McN-A-343 and AHR 602 on cardiac performance and the release of noradrenaline from sympathetic …
1974
Abstract 1 The effects of 4-(m-chlorophenylcarbamoyloxy)-2-butynyltrimethylammonium chloride (McN-A-343) and N-benzyl-3-pyrrolidyl acetate methobromide (AHR 602) on cardiac performance and noradrenaline release from terminal sympathetic fibres were measured in isolated perfused hearts of rabbits. 2 In the presence of sufficient atropine to block muscarinic receptors, high concentrations of McN-A-343 and AHR 602 caused no cardiac stimulation and there was no increase in the resting output of noradrenaline into the perfusates. 3 McN-A-343 and AHR 602 increased both the mechanical responses and the transmitter overflow evoked by electrical stimulation of the sympathetic nerves (SNS) but inhibi…
Ulcerative pyoderma gangrenosum associated with cocaine use
2020
Estrategias farmacológicas en el tratamiento de la adicción por cocaína
2006
Probablemente la cocaína está siendo consumida de forma alarmante debido en parte a la falsa idea de que no iba a producir las devastadoras consecuencias y efectos atribuidos a otras drogas de abuso. Sin embargo, su gran poder adictógeno, dificulta lograr el abandono del consumo y sí plantea graves problemas destacables y efectos secundarios potencialmente vitales.En esta adicción, destaca el polimorfismo de patología psíquica coexistente. Nos limitaremos a conceptuar el tratamiento de la propia adicción y a esquematizarlo al máximo para favorecer la mayor claridad posible, dado que existen numerosos datos, referencias bibliográficas y publicaciones sobre el tema.El progreso en el conocimie…
Prepulse Inhibition of the Startle Reflex as a Predictor of Vulnerability to Develop Locomotor Sensitization to Cocaine
2020
Prepulse inhibition (PPI) of the startle reflex is a measure of sensory-motor synchronization. A deficit in PPI has been observed in psychiatric patients, especially those with schizophrenia and vulnerable subjects, since the neural bases of this disorder are also involved in the regulation of PPI. Recently, we have reported that baseline PPI levels in mice can predict their sensitivity to the conditioned reinforcing effects of cocaine in the conditioned place preference (CPP) paradigm. Mice with a low PPI presented a lower sensitivity to the conditioned rewarding effects of cocaine; however, once they acquired conditioned preference with a higher dose of the drug, a more persistent associa…
Patología dual y consumo de tóxicos en pacientes con trastorno bipolar: estado de la cuestión
2006
Objetivo: Explorar la comorbilidad en consumo de tóxicos y patología dual de pacientes con Trastorno Bipolar. Metodología: Revisión crítica de la bibliografía secundaria obtenida a través de la base de datos Medline asi como de diversas monografias sobre el tema. Resultados: Los pacientes bipolares presentan una alta prevalencia de abuso o dependencia de sustancias, siendo el alcohol el principal tóxico consumido, seguido por la cocaína. Este consumo se refleja en un empeoramiento del curso y pronóstico del trastorno afectivo. Conclusiones: Las cifras más altas de comorbilidad del trastorno bipolar corresponden a los trastornos por abuso y dependencia de sustancias. De hecho, los trastornos…