Search results for "coding"
showing 10 items of 920 documents
Computer-aided calculation of the molecular size of nondenatured proteins in pore-gradient gel electrophoresis
1991
A computer program written in Turbo C is described, which uses the two-step mathematical procedure published recently (Rothe, G. M., Electrophoresis 1988, 9, 307-316) to evaluate the molecular mass, Stokes' radius, spherical radius, and frictional coefficient of nondenatured proteins. The program runs on any IBM-PC or 100% compatible IBM-PC, provided the disk operating system MS-DOS or PC-DOS 3.0 or later has been installed. Functions that are permanently in use are accessible by menu. Storage and loading of data from disk and help instructions can be called by use of function keys. The program provides several tables into which inserted and calculated data is automatically integrated. Each…
Detection of mutations in the apolipoprotein CII gene by denaturing gradient gel electrophoresis. Identification of the splice site variant apolipopr…
1998
AbstractFamilial apolipoprotein (apo) CII deficiency is a rare autosomal recessive inborn error of metabolism clinically resembling lipoprotein lipase deficiency. A number of mutations of the apo CII gene are known to date; they are located in the promoter region, the coding exons, or in the splice junctions. We present a simple assay based on PCR and denaturing gradient gel electrophoresis, which allows scanning of the promoter, the entire coding sequence, and the splice junctions of the apo CII gene for sequence variants. All gene fragments are amplified using a common PCR protocol and are examined for mutations on a single gradient gel. Using this method and direct sequencing, we identif…
A Trajectory-Driven 3D Non-Stationary mm-Wave MIMO Channel Model for a Single Moving Point Scatterer
2021
This paper proposes a new non-stationary three-dimensional (3D) channel model for a physical millimeter wave (mm-Wave) multiple-input multiple-output (MIMO) channel. This MIMO channel model is driven by the trajectory of a moving point scatterer, which allows us to investigate the impact of a single moving point scatterer on the propagation characteristics in an indoor environment. Starting from the time-variant (TV) channel transfer function, the temporal behavior of the proposed non-stationary channel model has been analyzed by studying the TV micro-Doppler characteristics and the TV mean Doppler shift. The proposed channel model has been validated by measurements performed in an indoor e…
A combinatorial view on string attractors
2021
Abstract The notion of string attractor has recently been introduced in [Prezza, 2017] and studied in [Kempa and Prezza, 2018] to provide a unifying framework for known dictionary-based compressors. A string attractor for a word w = w 1 w 2 ⋯ w n is a subset Γ of the positions { 1 , … , n } , such that all distinct factors of w have an occurrence crossing at least one of the elements of Γ. In this paper we explore the notion of string attractor by focusing on its combinatorial properties. In particular, we show how the size of the smallest string attractor of a word varies when combinatorial operations are applied and we deduce that such a measure is not monotone. Moreover, we introduce a c…
Mappings of finite distortion: Sharp Orlicz-conditions
2003
We establish continuity, openness and discreteness, and the condition $(N)$ for mappings of finite distortion under minimal integrability assumptions on the distortion.
Sequence and evolution of the gene for the monomeric globin I and its linkage to genes coding for dimeric globins in the insect Chironomus thummi.
1995
We isolated genomic clones containing sequences encoding globins I and IA from a Chironomus thummi thummi genomic library. Three clones contain globin IA (ctt-1A) genes, while one contains a globin I (ctt-1) gene. The coding regions of the four genes are identical except for the single base substitution accounting for the globin I/IA polymorphism. The noncoding DNA flanking the coding region is more than 98% similar, confirming a previous hypothesis that the globin ctt-1 and ctt-1A genes are alleles. Hemoglobins I and IA are monomeric in the insect hemolymph. Earlier in situ hybridization studies suggested that monomeric and dimeric globin genes are clustered at different chromosomal loci. …
Using DNA barcodes to detect non-indigenous species: the case of the Asian copepod Mesocyclops pehpeiensis Hu, 1943 (Cyclopidae) in two regions of th…
2015
To date, little attention has been paid to analyses of copepods as exotic species. The genusMesocyclops, a freshwater cyclopoid, has a worldwide distribution, but individual species within the genus have a quite restricted geographical range.Mesocyclops pehpeiensisHu, 1943 is a Central-East Asian species, rarely found outside of this area, and when it appears should be considered as non-native. Based on morphology and DNA barcode analyses, using the COI gene, we confirmed records ofM. pehpeiensisin two ponds in Mexico and in a rice paddy near Valencia, Spain. The morphology of this species, based on morphometric analyses, was found to be variable, but DNA barcoding confirmed the same identi…
DNA barcode reference library for Iberian butterflies enables a continental-scale preview of potential cryptic diversity
2015
How common are cryptic species - those overlooked because of their morphological similarity? Despite its wide-ranging implications for biology and conservation, the answer remains open to debate. Butterflies constitute the best-studied invertebrates, playing a similar role as birds do in providing models for vertebrate biology. An accurate assessment of cryptic diversity in this emblematic group requires meticulous case-by-case assessments, but a preview to highlight cases of particular interest will help to direct future studies. We present a survey of mitochondrial genetic diversity for the butterfly fauna of the Iberian Peninsula with unprecedented resolution (3502 DNA barcodes for all 2…
Low frequency and rare coding variation contributes to multiple sclerosis risk
2018
AbstractMultiple sclerosis is a common, complex neurological disease, where almost 20% of risk heritability can be attributed to common genetic variants, including >230 identified by genome-wide association studies (Patsopoulos et al., 2017). Multiple strands of evidence suggest that the majority of the remaining heritability is also due to the additive effects of individual variants, rather than epistatic interactions between these variants, or mutations exclusive to individual families. Here, we show in 68,379 cases and controls that as much as 5% of this heritability is explained by low-frequency variation in gene coding sequence. We identify four novel genes driving MS risk independe…
Are polymorphisms of the β3 -adrenoceptor gene associated with an altered bladder function?
2012
Aims As the presence of a Trp64Arg polymorphism of the gene encoding the β3-adrenoceptor (B3AR) has been linked to the presence of overactive bladder, we investigated whether additional polymorphisms are detectable in this gene and explore their relationships parameters related to lower urinary tract function. Methods The coding region and adjacent stretches of the B3AR gene was sequenced in 91 patients. In total, 1015 patients from a single academic hospital were genotyped for the presence of two single nucleotide polymorphisms. Symptom scores and parameters from pressure-flow studies were analyzed relative to genotype in the B3AR gene. Results No frequent novel polymorphisms were detected…