Search results for "combination"
showing 10 items of 1379 documents
European protection of fundamental rights in environmental matters. Contribution to the study of the relationship between law and science
2019
The prevention and sanction aspects of the protection against the pollution is manifested in Europe by the combination and complementarity of two matters (environment and fundamental rights) and two legal orders (European Union and Council of Europe). They consist of the protection of the environment that a person can expect to obtain in the context of the protection of these rights. They allow the management of "new risks" and the assimilation of pollution to a violation of a fundamental right under conditions including scientific knowledge. Protection of fundamental rights in environmental matters raises the question of the place given to scientific demonstration in jurisdictional work an…
Safety of tiotropium and olodaterol fixed-dose combination for COPD in patients on β-blockers
2015
Introduction: The TONADO studies (NCT01431274; NCT01431287) established the efficacy and safety of a new once-daily fixed-dose combination (FDC) with tiotropium (T), a long-acting muscarinic antagonist, and olodaterol (O), a long-acting β 2 -agonist, for the treatment of COPD. This post hoc analysis evaluates T+O safety in the subgroup of patients (pts) receiving β-blockers (BBs) in these studies. Methods: These were randomised, double-blind, parallel-group, 52-week, Phase III trials comparing T+O FDC (2.5/5 µg; 5/5 µg) with the monocomponents. Adverse events (AEs) and serious AEs (SAEs) were recorded and SAEs independently adjudicated. Pooled safety data from pts receiving BBs at baseline …
Baum-Katz’s Type Theorems for Pairwise Independent Random Elements in Certain Metric Spaces
2020
In this study, some Baum-Katz’s type theorems for pairwise independent random elements are extended to a metric space endowed with a convex combination operation. Our results are considered in the cases of identically distributed and non-identically distributed random elements. Some illustrative examples are provided to sharpen the results. peerReviewed
Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment
2016
// Bregje van Oorschot 1 , Giovanna Granata 1 , Simone Di Franco 2 , Rosemarie ten Cate 1 , Hans M. Rodermond 1 , Matilde Todaro 3 , Jan Paul Medema 1 , Nicolaas A.P. Franken 1 1 Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine, Department of Radiation Oncology, Academic Medical Center, Cancer Genomics Center, Amsterdam, The Netherlands 2 Department of Surgical, Oncological and Stomatological Sciences (DICHIRONS), Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy 3 Biomedical Department of Internal and Specialistic Medicine (DIBIMIS), University of Palermo, Palermo, Italy Correspondence to: Nicol…
On the Bias of Syntactic Geometric Recombination in Genetic Programming and Grammatical Evolution
2015
For fixed-length binary representations as used in genetic algorithms, standard recombination operators (e.g.,~one-point crossover) are unbiased. Thus, the application of recombination only reshuffles the alleles and does not change the statistical properties in the population. Using a geometric view on recombination operators, most search operators for fixed-length strings are geometric, which means that the distances between offspring and their parents are less than, or equal to, the distance between their parents. In genetic programming (GP) and grammatical evolution (GE), the situation is different since the recombination operators are applied to variable-length structures. Thus, most r…
Design and simulation of efficient combinational circuits based on a new XOR structure in QCA technology
2021
AbstractQuantum-dot cellular automata (QCA), due to its unique characteristics like low power consumption, nanoscale design, and high computing speed is considered as an emerging technology, and it can be used as an alternative for CMOS technology in circuit design for quantum computers in the near future. XOR gate has many applications in the design of digital circuits in QCA. In this paper, an efficient novel structure of XOR gate is proposed in QCA. Also, a novel 1-bit comparator circuit, 1-bit full adder, binary to gray and gray to binary convertor code based on the proposed XOR is designed and simulated using QCADesigner 2.0.3. The simulation results demonstrated that the proposed stru…
In vitro evolution of an atrazine-degrading population under cyanuric acid selection pressure: Evidence for the selective loss of a 47kb region on th…
2011
International audience; The adaptation of microorganisms to pesticide biodegradation relies on the recruitment of catabolic genes by horizontal gene transfer and homologous recombination mediated by insertion sequences (IS). This environment-friendly function is maintained in the degrading population but it has a cost which could diminish its fitness. The loss of genes in the course of evolution being a major mechanism of ecological specialization, we mimicked evolution in vitro by sub-culturing the atrazine-degrading Pseudomonas sp. ADP in a liquid medium containing cyanuric acid as the sole source of nitrogen. After 120 generations, a new population evolved, which replaced the original on…
Quarkonium suppression in heavy-ion collisions: an open quantum system approach
2016
We address the evolution of heavy-quarkonium states in an expanding quark-gluon plasma by implementing effective field theory techniques in the framework of open quantum systems. In this setting we compute the nuclear modification factors for quarkonia that are $S$-wave Coulombic bound states in a strongly-coupled quark-gluon plasma. The calculation is performed at an accuracy that is leading-order in the heavy-quark density expansion and next-to-leading order in the multipole expansion. The quarkonium density-matrix evolution equations can be written in the Lindblad form, and, hence, they account for both dissociation and recombination. Thermal mass shifts, thermal widths and the Lindblad …
Quantum and classical dynamics of heavy quarks in a quark-gluon plasma
2018
We derive equations for the time evolution of the reduced density matrix of a collection of heavy quarks and antiquarks immersed in a quark gluon plasma. These equations, in their original form, rely on two approximations: the weak coupling between the heavy quarks and the plasma, the fast response of the plasma to the perturbation caused by the heavy quarks. An additional semi-classical approximation is performed. This allows us to recover results previously obtained for the abelian plasma using the influence functional formalism. In the case of QCD, specific features of the color dynamics make the implementation of the semi-classical approximation more involved. We explore two approximate…
Grazoprevir/elbasvir for the immediate treatment of recently acquired HCV genotype 1 or 4 infection in MSM.
2020
Abstract Background In Europe, increases in HCV infection have been observed over the last two decades in MSM, making them a key population for recently acquired HCV. Alternative combinations of direct-acting antiviral agents against early HCV infection need to be assessed. Patients and methods In this pilot trial, MSM with recently acquired genotype 1 or 4 HCV infection were prospectively included and received 8 weeks of oral grazoprevir 100 mg and elbasvir 50 mg in a fixed-dose combination administered once daily. The primary endpoint was sustained virological response evaluated 12 weeks after the end of treatment (EOT) (SVR12). Secondary endpoints were the virological characterization of…