Search results for "compatibility"

Opportunities and Challenges of Fluorescent Carbon Dots in Translational Optical Imaging

2015

The fluorescent carbon dot (C-dot) is a new class of carbon nanomaterials. It has a discrete or quasispherical structure, typically measures less than 10 nm and contains sp(2)/sp(3) carbon, oxygen/nitrogen-based groups and surface-modified functional groups. Compared with semiconductor quantum dots (QDs), C-dots offer much lower toxicity and a better biocompatibility profile. Their other favorable features include easy and inexpensive synthesis and surface modification potential. C-dots can be morphologically classified into graphene-based quantum dots (GQDs) and amorphous carbon nanodots (ACNDs). Numerous methods have been developed to synthesize C-dots, and are mainly divided into 'top-do…

Third Keystone Symposium on Cellular Immunology and the Immunotherapy of Cancer Antigen Processing and Presentation Autologous Human Dendriphages Pul…

1998

The recent identification of tumor-associated antigens and tumor-associated antigen-derived peptide epitopes recognized by cytolytic T lymphocytes (CTLs) in the context of major histocompatibility complex (MHC) class I molecules has prompted the development of peptide-based vaccines for the treatment of human cancers, particularly melanoma. The design of such clinical protocols requires an understanding of the inherent immunogenicity of the peptide(s) and a choice of a facilitating adjuvant promoting cellular immunity against these peptides. We have evaluated the abilities of a series of defined synthetic peptide epitopes derived from MART- I/Melan-A, gp100, tyrosinase. and MAGE-3 or unfrac…

Effects of gamma interferon on a B16 melanoma cell line and its doxorubicin-resistant variant.

1992

Effects of triterpenes on the immune system.

2010

Ethnopharmacological relevance: Triterpenes, which comprise a broad chemical group of active principles, are implicated in the mechanisms of action and pharmacological effects of many medicinal plants used in folk medicine against diseases in which the immune system is implicated. They have been described as anti-inflammatory, antiviral, antimicrobial, and antitumoral agents, as well as being immunomodulator compounds. Several of them are implicated in the resolution of immune diseases, although their effects have not always been clearly correlated. Aim of the review: The aim of this review is to compile relevant data on the mechanisms of action of triterpenes isolated from active ethnomedi…

Inulin Derivatives Obtained <i>Via</i> Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery

2015

A new class of therapeutic agents with a high potential for the treatment of different socially relevant human diseases is represented by Nucleic Acid Based Drugs (NABD), including small interfering RNAs (siRNA), decoy oligodeoxynucleotides (decoy ODN) and antisense oligonucleotides (ASOs). Although NABD can be engineered to be specifically directed against virtually any target, their susceptibility to nuclease degradation and the difficulty of delivery into target tissues severely limit their use in clinical practice and require the development of an appropriate nanostructured delivery system. For delivery of NABD, Inulin (Inu), a natural, water soluble and biocompatible polysaccharide, wa…

Stability of mycophenolate mofetil in polypropylene 5% dextrose infusion bags and chemical compatibility associated with the use of the Equashield ® …

2019

Stability studies are necessary in healthcare settings as they facilitate fast, cost-effective and efficient work related to batch manufacturing and availability of supplies. We studied the stability of 1-10 mg/mL mycophenolate mofetil (MMF) in polypropylene 5% dextrose infusion bags prepared from Cellcept® and with a generic brand name (Micofenolato de Mofetilo Accord) at different storage temperatures. To ensure chemical compatibility during preparation, we also tested MMF sorption to the Equashield® closed-system drug transfer device used in this step. For this, a validated stability-indicating high-performance liquid chromatography method was developed for the quantification and identif…

Betasympathomimetika und andere Arzneimittel zur Feuchtinhalationstherapie

2011

European Databases on Stability and Compatibility of Injectable Medicinal Products in Europe

2020

AbstractIn hospitals, the majority of medication therapy is administered intravenously. Especially, in intensive care units, simultaneous of various injectable drugs is a common practice Drug incompatibilities have been reported to be associated with up to 60 % of all serious and life-threatening adverse drug events. Several databases are used by hospital pharmacists to answer the questions of (in)compatibility of co-administered injectable drugs. The objective of this article is to present the European databases on compatibility and stability of injectable drugs. According to a questionnaire which was sent to the National Hospital Pharmacy Associations of the 28 countries of European Commu…

Some aspects of deformations of supersymmetric field theories

2000

We investigate some aspects of Moyal-Weyl deformations of superspace and their compatibility with supersymmetry. For the simplest case, when only bosonic coordinates are deformed, we consider a four dimensional supersymmetric field theory which is the deformation of the Wess-Zumino renormalizable theory of a chiral superfield. We then consider the deformation of a free theory of an abelian vector multiplet, which is a non commutative version of the rank one Yang-Mills theory. We finally give the supersymmetric version of the $\alpha'\mapsto 0$ limit of the Born-Infeld action with a B-field turned on, which is believed to be related to the non commutative U(1) gauge theory.

Full Wave Solution for Intel CPU With a Heat Sink for EMC Investigations

2010

A CPU with a heat sink (e.g. Intel Pentium 4 and Intel Pentium dual core) is a challenging problem for EMC analysis. A Very Large Scale Integrated (VLSI) device was modelled using the Finite Element Method (FEM) frequency domain solver to obtain a 3D full wave solution. The electromagnetic (EM) radiation emitted from these high power microelectronic circuits connected to a heat sink was found to have resonant frequencies around 2.4 GHz and 5 GHz with reflection coefficients less than -19 dB and -8 dB respectively. These resonant frequencies are very close to the operating frequency of both IEEE and Bluetooth wireless communication systems. This paper proposes a new benchmark model based on …