Search results for "complement"
showing 10 items of 2113 documents
Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane permeabilization-dependent mechanism.
2012
The phenolic phytoalexin resveratrol is well known for its health-promoting and anticancer properties. Its potential benefits are, however, limited due to its low bioavailability. Pterostilbene, a natural dimethoxylated analog of resveratrol, presents higher anticancer activity than resveratrol. The mechanisms by which this polyphenol acts against cancer cells are, however, unclear. Here, we show that pterostilbene effectively inhibits cancer cell growth and stimulates apoptosis and autophagosome accumulation in cancer cells of various origins. However, these mechanisms are not determinant in cell demise. Pterostilbene promotes cancer cell death via a mechanism involving lysosomal membrane …
Assessment Tests in the Mathematics Teaching Guides in Spain. Analysis of the Content Blocks and the Treatment of Arithmetic Word Problems
2021
The teaching guides that complement textbooks have key importance in the assessment of competence in problem solving, because these materials contain the assessment tools that teachers frequently use to quantify the achievements of their students. In this paper, we set two aims: to analyze which curriculum contents are given priority in the assessment tests of the teaching guides
Teaching Public Administration Abroad through the Fulbright Specialist Program
2011
The purpose of this article is to promote the benefits of the Fulbright Specialist Program—which was created in 2001 as a short-term complement to the Fulbright Scholar Program—and to encourage more public administration scholars to consider teaching abroad. After providing an overview of the Fulbright Specialist Program and the collaborative teaching approach we used for the preparation and delivery of instructional materials, it presents a number of lessons learned from the perspective of the Fulbright Specialist and the host institution for maximizing the experience of teaching abroad. This article also is dedicated to the work of Fulbright, which has pursued its mission to increase mutu…
Systemic PaO2 oscillations cause mild brain injury in a pig model
2016
OBJECTIVE: Systemic PaO2 oscillations occur during cyclic recruitment and derecruitment of atelectasis in acute respiratory failure and might harm brain tissue integrity. DESIGN: Controlled animal study. SETTING: University research laboratory. SUBJECTS: Adult anesthetized pigs. INTERVENTIONS: Pigs were randomized to a control group (anesthesia and extracorporeal circulation for 20 hr with constant PaO2, n = 10) or an oscillation group (anesthesia and extracorporeal circulation for 20 hr with artificial PaO2 oscillations [3 cycles min⁻¹], n = 10). Five additional animals served as native group (n = 5). MEASUREMENTS AND MAIN RESULTS: Outcome following exposure to artificial PaO2 oscillations…
Humoral autoreactivity directed against surfactant protein-A (SP-A) in rheumatoid arthritis synovial fluids.
2000
SUMMARY SP-A is found principally in the lung, and has been associated with lamellar bodies also found in the synovial joint. Both SP-A and C1q contain collagen-like regions, and SP-A and C1q have some structural similarities, both having a globular head region and a collagen-like tail. Here we are able to show that (i) autoreactivity to SP-A, as expressed by IgG and IgM autoantibodies, is present in synovial fluid (SF) isolated from patients with rheumatoid arthritis (RA); (ii) in absorption experiments only a limited degree of cross-reactivity between autoantibodies reactive with C1q and SP-A is observed; (iii) there is no cross-reactivity between autoantibodies reactive with type II coll…
Treatment with C1-esterase inhibitor concentrate in type I or II hereditary angioedema: a systematic literature review.
2013
Hereditary angioedema (HAE) due to C1 esterase inhibitor (HAE-C1-INH) deficiency is a rare genetic disorder presenting with recurrent episodes of skin swellings, abdominal pain attacks, and potentially fatal laryngeal edema. This study was designed to review the efficacy and safety of pasteurized, human, plasma-derived C1-INH concentrate for the treatment of patients with HAE-C1-INH. A systematic search of electronic databases up to December 2011 was performed without language or date restrictions. Two reviewers completed the study selection using predefined inclusion criteria, tabulated, and analyzed the data. The data were inappropriate for meta-analysis; thus, a qualitative synthesis was…
Efficacy of C1 esterase inhibitor concentrate in treatment of cutaneous attacks of hereditary angioedema.
2015
BACKGROUND Although treatment with C1 esterase inhibitor (C1-INH) concentrate is well established for hereditary angioedema (HAE) attacks in general, data that assess its efficacy for cutaneous attack treatment are sparse. OBJECTIVE To assess efficacy of plasma-derived, nanofiltered C1-INH concentrate for cutaneous attack treatment by comparing treated attacks from the uncontrolled I.M.P.A.C.T.2 study with historical data for untreated attacks. METHODS Cutaneous attack data from patients with HAE who were treated for cutaneous edema with 20 IU/kg body weight C1-INH concentrate in the uncontrolled I.M.P.A.C.T.2 study (38 patients) were compared with data from untreated patients from an histo…
Chronological expression of Ciliated Bronchial Epithelium 1 during pulmonary development
2009
Ciliated Bronchial Epithelium (CBE) 1 is a novel gene, which is expressed in ciliated cells. As cilia are important during embryogenesis, the present authors characterised the murine homologue of CBE1 (Cbe1) and compared its temporal expression during murine and human lung development. Cbe1 cDNA was cloned and characterised using sequencing, standard PCR and Western blotting. Mouse and human embryonic/fetal lungs (HELs) were harvested for mRNA analysis and protein localisation in vivo and in vitro using RT-PCR and immunohistochemistry. The Cbe1 amino acid sequence was >75% identical with CBE1 and its alternative splicing and tissue distribution were highly conserved. Pulmonary expression of…
Hardy inequalities and Assouad dimensions
2017
We establish both sufficient and necessary conditions for weighted Hardy inequalities in metric spaces in terms of Assouad (co)dimensions. Our sufficient conditions in the case where the complement is thin are new even in Euclidean spaces, while in the case of a thick complement we give new formulations for previously known sufficient conditions which reveal a natural duality between these two cases. Our necessary conditions are rather straight-forward generalizations from the unweighted case, but together with some examples they indicate the essential sharpness of our results. In addition, we consider the mixed case where the complement may contain both thick and thin parts.
Existence and almost uniqueness for p -harmonic Green functions on bounded domains in metric spaces
2020
We study ($p$-harmonic) singular functions, defined by means of upper gradients, in bounded domains in metric measure spaces. It is shown that singular functions exist if and only if the complement of the domain has positive capacity, and that they satisfy very precise capacitary identities for superlevel sets. Suitably normalized singular functions are called Green functions. Uniqueness of Green functions is largely an open problem beyond unweighted $\mathbf{R}^n$, but we show that all Green functions (in a given domain and with the same singularity) are comparable. As a consequence, for $p$-harmonic functions with a given pole we obtain a similar comparison result near the pole. Various c…