Search results for "complement"
showing 10 items of 2113 documents
Host immune response to Cryptosporidium parvum infection
2010
Species of the genus Cryptosporidium are protozoan parasites (Apicomplexa) that cause gastroenteritis in animals and humans. Of these Cryptosporidium parvum and Cryptosporidium hominis are the major causative agents of human cryptosporidiosis. Whereas infection is self-limiting in the immunocompetent hosts, immunocompromised individuals develop a chronic, life-threatening disease. As specific therapeutic or preventive interventions are not yet available, better understanding of the immune response to the parasite is required. This minireview briefly summarizes the factors involved in the innate and acquired immune response in this pathogen-host interaction with an emphasis on more recent da…
Promoter and exon–intron structure of the protein kinase C gene from the marine sponge Geodia cydonium: evolutionary considerations and promoter acti…
1999
Abstract We report the gene structure of a key signaling molecule from a marine sponge, Geodia cydonium. The selected gene, which codes for a classical protein kinase C (cPKC), comprises 13 exons and 12 introns; the introns are, in contrast to those found in cPKC from higher Metazoa, small in size ranging from 93 nt to 359 nt. The complete gene has a length of 4229 nt and contains exons which encode the characteristic putative regulatory and catalytic domains of metazoan cPKCs. While in the regulatory domain only one intron is in phase 0, in the catalytic domain most introns are phase 0 introns, suggesting that the latter only rarely undergo module duplication. The 5′-flanking sequence of t…
ICT USE AT STUDENTS: RISKS AND RESOURCES
2019
L’usage des technologies de l’information et de la communication (TIC : Internet, réseaux sociaux, téléphone portable) est largement répandu chez les étudiants. Nous nous proposons de faire un état des lieux concernant les relations entre les étudiants et les TIC sous deux axes opposés : l’axe psychopathologique et l’axe « ressource ». D’un côté sont recensées les pathologies liées à l’usage de ces supports (usage problématique et addictions – notamment à la pornographie, cyberharcèlement) en termes de fréquence et de comorbidités. D’un autre côté, nous faisons l’état des lieux des dispositifs basés sur les TIC à visée de ressources, d’aide et de soin : de l’immersion en réalité virtuelle, …
Emerging Therapies in Immune Thrombocytopenia
2021
Immune thrombocytopenia (ITP) is a rare autoimmune disorder caused by peripheral platelet destruction and inappropriate bone marrow production. The management of ITP is based on the utilization of steroids, intravenous immunoglobulins, rituximab, thrombopoietin receptor agonists (TPO-RAs), immunosuppressants and splenectomy. Recent advances in the understanding of its pathogenesis have opened new fields of therapeutic interventions. The phagocytosis of platelets by splenic macrophages could be inhibited by spleen tyrosine kinase (Syk) or Bruton tyrosine kinase (BTK) inhibitors. The clearance of antiplatelet antibodies could be accelerated by blocking the neonatal Fc receptor (FcRn), while n…
Spacelike energy of timelike unit vector fields on a Lorentzian manifold
2004
On a Lorentzian manifold, we define a new functional on the space of unit timelike vector fields given by the L2 norm of the restriction of the covariant derivative of the vector field to its orthogonal complement. This spacelike energy is related with the energy of the vector field as a map on the tangent bundle endowed with the Kaluza–Klein metric, but it is more adapted to the situation. We compute the first and second variation of the functional and we exhibit several examples of critical points on cosmological models as generalized Robertson–Walker spaces and Godel universe, on Einstein and contact manifolds and on Lorentzian Berger’s spheres. For these critical points we have also stu…
Calculus Artefacts in Chinese Textbooks: Variational Approaches with Prospective Primary Teachers
2022
The first part of the paper presents some theoretical reflections and some methodological notes about a Professional Development (PD) path worked out during the last two years by Italian researchers for prospective primary teachers. The theoretical construct of Cultural Transposition defines the framework of the PD path’s activities and the related research. It was used to define an interesting cultural lens to delineate possible new approaches for effective pre-service teacher education programs in particular for the primary level. The defined methodology was based on the possibility to reflect on the he decentralization of didactic practices based on a specific cultural context through on…
Could telemedicine enhance traditional medicine practices?
2014
International audience; In developing countries, telemedicine and mobile health tools promise to enhance access to high-quality healthcare, to support communication of medical information and to assist pharmacovigilance processes. In this article, we provide some arguments on the potential of telemedicine and mobile health (mHealth) applications to improve the delivery of health care in rural African regions. Specifically, the development of mobile telemedicine could help to lay the foundations of a healthcare approach integrating modern medical knowledge with ancient medical practices on the African continent. Access to information and communication technology (ICT), technical devices or p…
A homolog of the putative tumor suppressor QM in the sponge Suberites domuncula: downregulation during the transition from immortal to mortal (apopto…
1999
Abstract The activation of components of the transcription factors such as AP-1 or c-jun is essential for a physiological response of metazoan cells during aging. The activity of such proto-oncoproteins is under enzymatic control. The function of c-jun is additionally modulated by the QM protein. Here, we studied the expression of the gene, encoding the QM-like protein in the sponge Suberites domuncula . These animals contain high levels of telomerase in their somatic cells. To understand the switch from telomerase-positive immortal cells to telomerase-negative mortal cells which undergo apoptosis, the expression of the QM-like gene was measured in this system. The cDNA, termed QMSD , encod…
Diagrammatic approach to cellular automata and the emergence of form with inner structure
2018
We present a diagrammatic method to build up sophisticated cellular automata (CAs) as models of complex physical systems. The diagrams complement the mathematical approach to CA modeling, whose details are also presented here, and allow CAs in rule space to be classified according to their hierarchy of layers. Since the method is valid for any discrete operator and only depends on the alphabet size, the resulting conclusions, of general validity, apply to CAs in any dimension or order in time, arbitrary neighborhood ranges and topology. We provide several examples of the method, illustrating how it can be applied to the mathematical modeling of the emergence of order out of disorder. Specif…
Heterogeneous network games: Conflicting preferences
2013
Proceeding at: 2nd Annual UECE Lisbon Meeting: Game Theory and Applications, took place 2010, November, 4-6, in Lisbon (Portugal). The event Web site http://pascal.iseg.utl.pt/~uece/lisbonmeetings2010/ In many economic situations, a player pursues coordination or anti-coordination with her neighbors on a network, but she also has intrinsic preferences among the available options. We here introduce a model which allows to analyze this issue by means of a simple framework in which players endowed with an idiosyncratic identity interact on a social network through strategic complements or substitutes. We classify the possible types of Nash equilibria under complete information, finding two thr…