Search results for "complement"

Autoantikörper gegen die Komplementkomponente C1q beim Systemischen Lupus Erythematodes

1990

Autoantibodies against C1q, a subcomponent of the first complement component C1, could be detected in 49.4% of sera from patients with systemic lupus erythematosus (SLE). They are directed against the collagen-like portion of the C1q molecule and recognize only bound, but not fluid-phase C1q. The appearance of these autoantibodies in the course of SLE correlates with the detection of IgG in the C1q-Solid-Phase-Bindingassay, with high titres of dsDNA-antibodies and with depressed total complement activity (CH50) and C1q-values. Our investigations show that autoantibodies against the collagen-like portion of bound C1q but not immune complexes are the main constituent of C1q-binding IgG in SLE.

ABO blood groups and Australia antigen

2008

The distribution of ABO blood in two groups of people with Australia antigen was studied (121 blood donors and 128 patients) and in 3,091 controls was investigated. There was a significant excess of A in comparison with o when the two groups were combined, and when the two groups were tested for (A + B): (AB +O) individually and together, both were found to be statistically significant. The results are discussed.

Arthritis-regulating determinants on the collagen-like complement component C1q

1992

An Innovative Similarity Measure for Sentence Plagiarism Detection

2016

We propose and experimentally assess Semantic Word Error Rate (SWER), an innovative similarity measure for sentence plagiarism detection. SWER introduces a complex approach based on latent semantic analysis, which is capable of outperforming the accuracy of competitor methods in plagiarism detection. We provide principles and functionalities of SWER, and we complement our analytical contribution by means of a significant preliminary experimental analysis. Derived results are promising, and confirm to use the goodness of our proposal.

La investigación en Ciencias Laborales como una nueva dimensión del alumnado universitario. Una experiencia innovadora

2016

Profesorado del Grado de Relaciones Laborales y Recursos Humanos de la Universitat de València, se planteó en el curso 2013-2014, y dado que la titulación había pasado de Diplomatura a Grado, la necesidad de fomentar entre el alumnado la orientación investigadora, opción hasta dicho momento difícil de desarrollar. Por eso, a través del desarrollo del proyecto de innovación en dicho curso «Medios para la difusión de resultados de investigaciones en Ciencias Laborales», se creó una web (http://inveslab.blogs.uv.es/) en la que se recogieron los resultados obtenidos del mismo, un repositorio con los medios existentes para la difusión de los resultados de investigaciones en Ciencias Laborales. T…

Identification of Metastasis Associated Antigen 1 (MTA1) by Serological Screening of Prostate Cancer cDNA Libraries

2008

Over the past 10 years the serological analysis of recombinant cDNA expression libraries (SEREX) has proved to be an effective method for the identification of tumour antigens. In the present study, two prostate cancer libraries were constructed and screened using autologous sera. Fifty five genes were isolated, including 46 known genes and 9 previously uncharacterised genes. Among the known genes, a metastasis-associated gene, MTA1, previously identified by differential cDNA hybridisation, was preferentially expressed in a panel of malignant tissues compared with normal tissues, as analysed by reverse transcriptase-polymerase chain reaction (RT-PCR). MTA1 transcripts were observed to be ov…

Peptides from NM23B - A Transcription Factor with NDP Kinase Activity - Are Expressed on the Surface of Leukemic Cells and Are Recognized by T-Lympho…

2005

Abstract Objective: During the last years a growing number of MHC-restricted antigens were recognized using autologous or HLA-matched cytotoxic T-cell lines (TCL). Molecules were isolated by HPLC or identified using cDNA expression cloning from normal or malignant target cells and found to derive from normal proteins or from mutated tumor-specific proteins. The majority of the tumor-specific peptides were derived from melanoma cells. The aim of this project was to search for immunogenic peptides on leukemia cells with the help of TCLs obtained from a stem cell donor against chronic myelogenous leukaemia (CML) recipient cells and to identify the immunogenic peptides by cDNA expression clonin…

A review of the biological and pharmacological activities of saponins.

1996

Summary This paper reviews the important biological and pharmacological activities of saponins reported over the last few years. These include cancer-related activity, as well as antiphlogistic and antiallergic, immunomodulating, antihepatotoxic, antiviral, hypoglycemic, antifungal and molluscicidal activities. The action of saponins on the cardiovascular, central nervous, and endocrine systems and other miscellaneous effects are also discussed.

Strutture e trasformazioni condivise in matematica e musica: dalle categorie alla musicologia / Shared structures and transformations in mathematics …

2018

Le mutue influenze tra scienza e musica, iniziate con Pitagora, caratterizzano la ricerca musicale contemporanea, dalla teoria all'analisi della performance. La matematica può collegare campi diversi: in particolare, la teoria matematica delle categorie e, più in generale, il pensiero diagrammatico, costituiscono un potente strumento per analizzare i processi e le trasformazioni tra i processi. Una categoria è data da oggetti (punti) e trasformazioni tra di loro (frecce), che verificano la proprietà associativa e possiedono l’elemento neutro. Punti e frecce costituiscono diagrammi. Un'intera categoria può essere vista come un punto e le trasformazioni tra categorie possono essere rappresent…

Le domande computer-based dell'indagine OCSE-Pisa e le domande INVALSI: uno studio sperimentale sul confronto tra i due strumenti di somministrazione

2016

Le valutazioni standardizzate stanno orientandosi verso la somministrazione computer-based; in quest'ottica, la ricerca si è concentrata principalmente sull'analisi della comparabilità dei risultati e sullo studio delle eventuali differenze nelle performance degli allievi dovuti al passaggio ad un nuovo ambiente di somministrazione. Tale passaggio è tutt’altro che neutro. Questo articolo presenta la prima fase di una ricerca più ampia che si propone di indagare in maniera analitica le differenze di comportamento di studenti coinvolti nella risoluzione di test somministrati in ambiente cartaceo e computerizzato. L’obiettivo è definire e validare degli strumenti di analisi che permettano di e…