Search results for "complementary and alternative medicine"
showing 10 items of 632 documents
2017
A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A–D (2–5), along with nine known compounds (6–14), were isolated from the CH2Cl2/CH3OH (1:1) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography. Maximaisoflavone J (11) and oblarotenoid C (4) showed weak activity against the human breast cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8 μM, respectively.
Phytotoxic Lignans from Artemisia arborescens
2018
A systematic bioassay-guided fractionation of methylene chloride extracts of the aerial part of Artemisia arborescens was performed in order to identify its phytotoxic compounds Two lignans were isolated, sesamin and ashantin, that inhibited growth of Agrostis stolonifera (bentgrass), a monocot, and Lactuca sativa (lettuce), a dicot, at 1 mg mL–1. In a dose-response screening of these lignans for growth inhibition against Lemna paucicostata (duckweed), ashantin was the most active with an IC50 of ca. 224 μM. The mode of action of these compounds is still unknown. In mosquito larvicidal bioassays the pure compounds sesamin and ashantin did not cause mortality at the highest dose of 125 mg/L…
Synthesis and Biological Evaluation of Combretastatin A-4 and Three Combretastatin-Based Hybrids
2012
The syntheses of combretastatin A-4 from gallic acid and of three combretastatin-based hybrids are described. Starting from commercial gallic acid, the phosphonium salt (3,4,5-trimethoxybenzylphosphonium bromide) is synthesized and coupled, through a Wittig reaction, with several aldehydes, including methoxymethyl-protected isovanillin, the aldehyde γ-bicyclohomofarnesal having a labdane skeleton, 3-(3-pyridyl) propanal, and furfural. The biological properties of the cis-coupled compounds as cytotoxic, antiviral and antifungal agents are also reported. In addition, pyrogallol, gallic and 3,4,5-trimethoxybenzoic acids have been studied biologically.
Biopiracy of medicinal plants: Finding fair solutions for the use of natural resources.
2019
Preclinical studies on the significance of mistletoe preparations in the therapy of urological tumors
2019
Synthesis of Sesquiterpenes via silicon-guided rearrangement of epoxydecalins
2008
A survey of the rearrangement of methyldecalins via C-5 carbocation intermediates, with special attention to the silicon-guided rearrangement of epoxydecalins is provided. A TMS group properly positioned on either C-1 or C-9 promotes the acidic rearrangement of 10-methyl-4,5-epoxydecalins and 10-methyl-5,6-epoxydecalins with exclusive migration toward C-5 of the methyl or methylene groups linked directly to C-10. The application of this biomimetic approach to the synthesis of a number of spirocyclic and eremophilane sesquiterpenes is reported.
[Zur antibakteriellen Wirkung von Clavinalkaloiden und deren partialsynthetischen Derivaten].
1982
Ursane-type saponins from Zygophyllum cornutum
2013
Seven known ursane-type saponins were isolated from the methanolic extract of the whole plant of Zygophyllum cornutum Coss, and identified by 2D NMR spectroscopy and FAB-mass spectrometry. They are reported in this species for the first time and might be chemotaxonomically significant for the genus Zygophyllum.