Search results for "complex"
showing 10 items of 5889 documents
A formal model based on Game Theory for the analysis of cooperation in distributed service discovery
2016
New systems can be designed, developed, and managed as societies of agents that interact with each other by offering and providing services. These systems can be viewed as complex networks where nodes are bounded rational agents. In order to deal with complex goals, they require cooperation of the other agents to be able to locate the required services. The aim of this paper is formally and empirically analyze under which circumstances cooperation emerges in decentralized search of services. We propose a repeated game model that formalizes the interactions among agents in a search process where agents are free to choose between cooperate or not in the process. Agents make decisions based on…
A note on symmetry reduction for circular traveling tournament problems
2011
Abstract The traveling tournament problem (TTP) consists of finding a distance-minimal double round-robin tournament where the number of consecutive breaks is bounded. Easton et al. (2001) introduced the so-called circular TTP instances, where venues of teams are located on a circle. The distance between neighboring venues is one, so that the distance between any pair of teams is the distance on the circle. It is empirically proved that these instances are very hard to solve due to the inherent symmetry. This note presents new ideas to cut off essentially identical parts of the solution space. Enumerative solution approaches, e.g. relying on branch-and-bound, benefit from this reduction. We…
Place brand as an emergent property: The case of Vascitour and Naples
2019
In this paper, by adopting a systemic framework, we argue that place's adaptive connotation be considered as a mere result of endogenous processes but as a viable system that will remain viable if it can continue to answer the needs of its numerous heterogeneous internal and external socio-economic agents. Place can be seen as a complex adaptive system characterized by a more or less planned evolution, driven by both top-down and bottom-up processes, and composed of various interconnecting parts that, at the same time, can be seen as wholes at different levels as an holoarchy. The model of the holoarchy allows to consider the place as the result of both planned and spontaneous relationships…
On the Nature of Information Management in Complex and Natural Disasters
2015
Abstract The purpose of this paper is to present reflections on the nature of information management (IM) and its role and function to support coordination in one of the largest humanitarian crises of our time, the Syria crisis. Starting from general principles for humanitarian information management, we analyze the challenges that information managers face in conflict situations, when information is – more than anywhere else – a source of power and influence. This work outlines the interdependence of advocacy and operational information management, the sensitivity of information, and barriers to information sharing. The results are complex and highly interlaced information and coordination…
Information Decomposition in Multivariate Systems: Definitions, Implementation and Application to Cardiovascular Networks
2016
The continuously growing framework of information dynamics encompasses a set of tools, rooted in information theory and statistical physics, which allow to quantify different aspects of the statistical structure of multivariate processes reflecting the temporal dynamics of complex networks. Building on the most recent developments in this field, this work designs a complete approach to dissect the information carried by the target of a network of multiple interacting systems into the new information produced by the system, the information stored in the system, and the information transferred to it from the other systems; information storage and transfer are then further decomposed into amou…
Metal complexes of a novel heterocyclic benzimidazole ligand formed by rearrangement-cyclization of the corresponding Schiff base. Electrosynthesis, …
2018
The electrochemical oxidation of anodic metals (M = cobalt, nickel, copper, zinc and cadmium) in a solution of the ligand 1H-anthra[1,2-d]imidazol-6,11-dione-2-[2-hydroxyphenyl] [H2L] afforded homoleptic [ML] compounds. The addition to the electrochemical cell of coligands (L′) such as 2,2′-bipyridine (bpy) or 1,10-phenanthroline (phen) allowed the synthesis, in one step, of heteroleptic [MLL′] compounds. The crystal structures of H2L (1), [CoL(MeOH)]2 (2), [CoL(phen)]2 (3), [NiL(bpy)]2 (4), [CuL(bpy)] (5), [CuL(phen)] (6) and [CdL(bpy)]2 (7) have been determined by X-ray diffraction techniques. The crystal structures of 2, 3, 4 and 7 consist of dimeric species in which both metallic atoms …
ChemInform Abstract: Tucupentol, a Novel Mono-tetrahydrofuranic Acetogenin from Annona montana, as a Potent Inhibitor of Mitochondrial Complex I.
2009
Ten acetogenins, one of them new, were isolated from leaves and twigs of a Bolivian collection of Annona montana. The new compound that we named tucupentol (1) is a mono-tetrahydrofuran-pentahydroxy-acetogenin. The inhibitory potency of tucupentol (1) on the mitochondrial complex I was evaluated, and this activity was compared with that of the known acetogenins, annonacin-A, cis-annonacin-10-one, aromin, and gigantetronenin, also isolated from this plant material. The mentioned acetogenins acted as selective inhibitors of mitochondrial complex I in the 0.8-5.4-nM range.
Lipoprotein-induced phenoloxidase-activity in tarantula hemocyanin.
2015
Phenoloxidases play vital roles in invertebrate innate immune reactions, wound closure and sclerotization processes in arthropods. In chelicerates, where phenoloxidases are lacking, phenoloxidase-activity can be induced in the oxygen carrier hemocyanin in vitro by proteolytic cleavage, incubation with the artificial inducer SDS, or lipids. The role of protein-protein interaction has up to now received little attention. This is remarkable, as lipoproteins - complexes of proteins and lipids - are present at high concentrations in arthropod hemolymph. We characterized the three lipoproteins present in tarantula hemolymph, two high-density lipoproteins and one very high-density lipoprotein, and…
Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA.
2004
Primary defence against invading microorganisms depends on a functional innate immune system and the complement system plays a major role in such immunity. Deficiencies in one of the components of the complement system can cause severe and recurrent infections, systemic diseases, such as systemic lupus erythematosus (SLE) and renal disease. Screening for complement deficiencies in the classical or alternative complement pathways has mainly been performed by haemolytic assays. Here, we describe a simple ELISA-based format for the evaluation of three pathways of complement activation. The assays are based on specific coatings for each pathway in combination with specific buffer systems. We ha…
Do Immune Complexes Formed with Autoantibodies Have a Role in the Maintenance of Immune Homeostasis Through Interaction with FC Receptors
2000
Natural autoantibodies play an important regulatory role in the maintenance of immune homeostasis. They act as a first line of defense against environmental pathogens like toxins, bacteria and erythrocytes. In humans they are mainly produced by CD5+ B cells that are under the control of a regulatory T cell population. Fc-gamma receptors are involved in antigen recognition and signal transduction and tuning, and some of the members of the FcR family have structural similarity to MHC molecules; they may interact with multiple Ig ligands and with non-Ig ligands. We discuss the interactions between immune-complexes formed with natural autoantibodies and Fc-gamma receptors and suggest that such …