Search results for "complex"

Towards next-generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics.

2020

5 páginas, 2 figuras. AVAILABILITY AND IMPLEMENTATION: The database of non-tuberculous mycobacteria assemblies can be accessed at: 10.5281/zenodo.3374377. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online: http://dx.doi.org/10.1093/bioinformatics/btz729

Effects of 3rd-harmonic voltage content on dielectric losses of solid insulating materials

1981

Dielectric losses in solid insulating materials subjected to voltages containing 3rd harmonics are studied. By simple theoretical analysis, some curves are obtained showing the behaviour of the ratio between the dielectric losses in the distorted steady state and in a reference sinusoidal steady state, against 3rd-harmonic content. The reference sinusoidal voltage amplitudes were selected in two different ways; namely, such as to have either peak value or effective value equal to those of distorted waveform.Separate effects of harmonic content and of effective value of the applied voltage are shown through the correspondence of every 3rd-harmonic phase angle. Percentage differences between …

Steady-state and tracking analysis of a robust adaptive filter with low computational cost

2007

This paper analyses a new adaptive algorithm that is robust to impulse noise and has a low computational load [E. Soria, J.D. Martin, A.J. Serrano, J. Calpe, and J. Chambers, A new robust adaptive algorithm with low computacional cost, Electron. Lett. 42 (1) (2006) 60-62]. The algorithm is based on two premises: the use of the cost function often used in independent component analysis and a fuzzy modelling of the hyperbolic tangent function. The steady-state error and tracking capability of the algorithm are analysed using conservation methods [A. Sayed, Fundamentals of Adaptive Filtering, Wiley, New York, 2003], thus verifying the correspondence between theory and experimental results.

Stabilization of ZSM-5 zeolite catalysts for steam catalytic cracking of naphtha for production of propene and ethene

2012

In order to increase ethene and propene, naphtha steam catalytic cracking has been considered. The cracking of C 5-C 12 n-alkanes with ZSM-5 has been studied in absence and in presence of steam and the influence of the operation variables was studied. Irreversible catalyst deactivation by dealumination also occurs in the reactor when the cracking is carried out in the presence of steam. To diminish steam deactivation, the influence of zeolite Si/Al framework and a postsynthesis treatment by phosphorous have been studied and optimized. Much more stable catalyst can be achieved that result in an increase in activity without penalty for production of ethene and propene.

An algebraic representation of Steiner triple systems of order 13

2021

Abstract In this paper we construct an incidence structure isomorphic to a Steiner triple system of order 13 by defining a set B of twentysix vectors in the 13-dimensional vector space V = GF ( 5 ) 13 , with the property that there exist precisely thirteen 6-subsets of B whose elements sum up to zero in V , which can also be characterized as the intersections of B with thirteen linear hyperplanes of V .

tBuLi-Mediated One-Pot Direct Highly Selective Cross-Coupling of Two Distinct Aryl Bromides.

2015

A Pd-catalyzed direct cross-coupling of two distinct aryl bromides mediated by tBuLi is described. The use of [Pd-PEPPSI-IPr] or [Pd-PEPPSI-IPent] as catalyst allows for the efficient one-pot synthesis of unsymmetrical biaryls at room temperature. The key for this selective cross-coupling is the use of an ortho-substituted bromide that undergoes lithium-halogen exchange preferentially.

CO-releasing binuclear rhodium complexes as inhibitors of nitric oxide generation in stimulated macrophages.

2013

Nontoxic CO-releasing dirhodium complexes act as inhibitors of NO in stimulated macrophage cells, suggesting that novel antiinflammatory treatments could involve the use of these types of binuclear complexes.

Semisynthesis of antitumoral acetogenins: SAR of functionalized alkyl-chain bis-tetrahydrofuranic acetogenins, specific inhibitors of mitochondrial c…

2000

The acetogenins of Annonaceae are known by their potent cytotoxic activity. In fact, they are promising candidates as a new future generation of antitumoral drugs to fight against the current chemiotherapic resistant tumors. The main target enzyme of these compounds is complex I (NADH:ubiquinone oxidoreductase) of the mitochondrial respiratory chain, a key enzymatic complex of energy metabolism. In an attempt to characterize the relevant structural factor of the acetogenins that determines the inhibitory potency against this enzyme, we have prepared a series of bis-tetrahydrofuranic acetogenins with different functional groups along the alkyl chain. They comprise several oxo, hydroxylimino,…

Crystal structure, magnetic and spectroscopic properties of the bis(dimethyl sulfoxide) adduct of tetra-μ-formato-dicopper(II), a new tetracarboxylat…

1994

The crystal and molecular structure of a new tetracarboxylato-bridged copper(II) dimer, the bis(dimethyl sulfoxide)tetrakis(μ-formato)dicopper(II) has been determined by X-ray diffraction methods. It crystatlizes in the tetragonal space group I41/a, with Z=8 in a cell of dimensions a=17.688(2), c=10.408(1) Å. The structure is built up of centrosymmetric neutral dimers [Cu2(HCOO)4(dmso)2], where four bidentate carboxylate anions form syn-syn bridges between the metal atoms which are in a 4 + 1 environment. Magnetic susceptibility data show that the copper atoms are strongly antiferromagnetically coupled with J=-434 cm-1. The obtained triplet-singlet energy gap is compared with those reported…

2020

Electrophilic (het)arenes can undergo reactions with nucleophiles yielding π- or Meisenheimer (σ-) complexes or the products of the SNAr addition/elimination reactions. Such building blocks have only rarely been employed for the design of enzyme inhibitors. Herein, we demonstrate the combination of a peptidic recognition sequence with such electrophilic (het)arenes to generate highly active inhibitors of disease-relevant proteases. We further elucidate an unexpected mode of action for the trypanosomal protease rhodesain using NMR spectroscopy and mass spectrometry, enzyme kinetics and various types of simulations. After hydrolysis of an ester function in the recognition sequence of a weakly…