Search results for "complex"
showing 10 items of 5889 documents
cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel
2020
Abstract Background Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understanding of how the effects of genetic variants affect different molecular mechanisms to determine gut immunocompetence is still limited. Results To address this, we perform a systems genetics analysis of the gut transcriptomes from 38 DGRP lines that were orally infected with Pseudomonas entomophila. We identify a large number of condition-specific, expression quantitative trait loci (local-eQTLs) with infection-specific ones located …
Recycling of almond by-products for intestinal inflammation: improvement of physical-chemical, technological and biological characteristics of a drie…
2020
Background: Almond skins are rich in bioactive compounds that undergo oxidation/degradation phenomena and are poorly soluble in water, reducing in vivo absorption and bioavailability, factors that influence the pharmacological activity of an active product. We developed a dried acetonic almond skins extract/cyclodextrin complex to improve extract solubility, dissolution rate and biological activity. Methods: A lyophilized acetonic almond skin extract was produced. To optimize complex formulation, phase solubility studies and complex characterization (absorption studies, differential scanning calorimetry (DSC), morphology, solubility studies) were performed. To evaluate a possible use in hea…
Continuous Improvement on Detailed Design Phase : A Process Perspective
2020
The construction project being studied is a government investment related to the relocation of a biomedical institute delivering research-based knowledge and contingency support in the fields of animal health, fish health and food safety. The project covers a total of 63,000 square meters distributed over 10 buildings with a very high degree of complexity. The design alone has required 1 million hours, which relates to a client cost of about 100 million Euro. The purpose of this paper is to study the applied methodology for managing the detailed design to identify lessons learned from the project. The theory underlying the study is inspired by lean design management and design theory linked…
Softening of Silica Filled Styrene-Butadiene Rubber under Uniaxial Cyclic Loading
2016
Stress-strain behaviour of silica filled styrene-butadiene rubber showed strong hysteresis and cyclic softening, while these effects were almost negligible for the neat rubber. Significant Mullins effect occurs between the first and second loading cycles, whereupon samples reach their steady state after four repeated cycles. The degree of softening increases with volume content of silica characterizing the softening effect as a breakdown of the filler-formed microstructure defined by both, specific interactions in the filler associations and between the filler and rubber matrix. Contribution of different damage mechanisms to the total energy losses on different stages of extension was estim…
Volume Changes in Filled Rubber Under Uniaxial Cyclic Loading
2011
Styrene-butadiene rubber, neat and filled with different silica content was investigated under uniaxial cyclic loading under a constant crosshead speed, with increasing deformation amplitude in subsequent loading cycles. Rubber was investigated in order to evaluate the reversibility of structure rearrangements, occurring in rubber when subjected to cyclic loading. Volume uniformly increases with growing strain and shows hysteresis at unloading. After complete unloading, no residual strain changes are observed. These data are in good conformity with the data of density measurements, which were made on specimens before and after the tests. By correlating data, obtained from volume changes and…
Creating a Framework for Improving the Learnability of a Complex System
2006
When designing complex systems, it is crucial but challenging to make them easy to learn. In this paper, a framework for improving the learnability of a complex system is presented. A classification of factors affecting the learnability of a building modeling system as well as guidelines that refine the factors into practical ways of action are introduced. The factors and guidelines include issues related to the user interface, conformity of the system to user’s expectations, and training. The classification is based on empirical research during which learnability was assessed with several methods. The methodology and the classification of learnability factors can be used as references when…
On the typology of motion events in Aymara
2021
This paper investigates the lexicalization pattern of motion events in Aymara, an Andean language spoken in Bolivia, Peru, and Chile. After providing a description of the morphosyntax of translational motion events, this study aims at a preliminary typological classification of Aymara within the framework of Talmy’s typology (Talmy 2000). With this purpose, three diagnostic tests have been used to determine the basic framing-typology of motion events. These tests consider i) the size of manner-of-motion lexicon and, more broadly, the degree of manner salience, ii) the complex-path constructions and the use of ‘plus-ground’ clauses, iii) the expression of boundary-crossing. The results of th…
The effect of variation in developmental mode on the population dynamics of a spionid polychaete (Pygospio elegans) in a heterogeneous environment
2018
Larval life history, transmission strategies, and the evolution of intermediate host exploitation by complex life-cycle parasites
2007
Complex life-cycle parasites use their intermediate hosts both as an energy source and as a vessel for transmission to the next host in the life cycle. Parasites that grow rapidly to a large size may have high fitness (e.g. time spent in uninfective stages is limited), yet those that grow too aggressively may reduce host viability and their own probability of successful transmission. I examined aspects of both the growth and transmission strategy of an acanthocephalan (Acanthocephalus lucii) in its isopod intermediate host. In an experimental infection, the relative rate of larval parasite growth slowed over time, and eventually parasites seemed to reach a threshold biomass sustainable by t…
Complex dynamics, hidden attractors and continuous approximation of a fractional-order hyperchaotic PWC system
2018
In this paper, a continuous approximation to studying a class of PWC systems of fractionalorder is presented. Some known results of set-valued analysis and differential inclusions are utilized. The example of a hyperchaotic PWC system of fractional order is analyzed. It is found that without equilibria, the system has hidden attractors.