Search results for "complexe"
showing 10 items of 920 documents
Visualizing the atherosclerotic plaque: a chemical perspective.
2014
Atherosclerosis is the major underlying pathologic cause of coronary artery disease. An early detection of the disease can prevent clinical sequellae such as angina, myocardial infarction, and stroke. The different imaging techniques employed to visualize the atherosclerotic plaque provide information of diagnostic and prognostic value. Furthermore, the use of contrast agents helps to improve signal-to-noise ratio providing better images. For nuclear imaging techniques and optical imaging these agents are absolutely necessary. We report on the different contrast agents that have been used, are used or may be used in future in animals, humans, or excised tissues for the distinct imaging moda…
Does the origin of ablated premature ventricular contractions determine the level of left ventricular function improvement?
2020
Background: Premature ventricular contractions (PVCs) are associated with tachycardiomyopathy and high mortality rate. The treatment depends on the engaged ventricle. For PVCs originating from the right outflow tract (OT), radiofrequency catheter ablation (RFCA) is recommended (class IB‑R recommendation) in preference to pharmacotherapy. In those originating from the left ventricle, ablation is a class IIa B‑NR recommendation. Aims: The aim of the study was to assess the success of RFCA of PVCs based on arrhythmia origin. Methods: A total of 110 consecutive patients with monomorphic PVCs referred for ablation were enrolled and divided according to the site of ablation to the OT group and th…
The interaction of novel transition metal complexes and ligands with biomolecular targets: kinetic, thermodynamic and computational investigations.
Interaction of methyltin(IV) compounds with carboxylate ligands. Part 1: formation and stability of methyltin(IV)–carboxylate complexes and their rel…
2006
Quantitative data on the stability of mono-, di- and trimethyltin(IV)-carboxylate complexes (acetate, malonate, succinate, malate, oxydiacetate, diethylenetrioxydiacetate, tricarballylate, citrate, butanetetracarboxylate and mellitate) are reported at t=25°C and I → 0 mol l - 1 . Several mononuclear, mixed proton, mixed hydroxo and polynuclear species are formed in these systems. As expected, the stability trend is mono- > di- > trimethyltin(IV) and mono < di < tri < tetra < hexa for the organotin moieties and carboxylate ligands investigated, respectively. Moreover, ligands containing, in addition to carboxylic,-O-and-OH groups show a significantly higher stability with respect to analogou…
Novel platinum(II) complexes with heterociclyc ligands: Synthesis and structural chracterization.
2008
An array of mononuclear complexes of Pt(II) with triazine and (benzimidazolyl)pyridine heterocycles is reported. The mononuclear complexes [PtCl2(Kdptdn)] [dbtdn=5,6- diphenyl-3-(2-pyridyl)-1,2,4-triazine-4’,4’’-disulfonate sodium salt hydrate], [PtCl2(bbp)] [bbp=2,6-bis(2-benzimidazolyl)pyridine] and [PtCl2(H2dpt)]PtCl4 [dpt=5,6-diphenyl-3-(2- pyridyl)-1,2,4-triazine] have been prepared and structurally characterized. Both neutral and ionic complexes are present, with bifunctional Pt(II) moieties, whose size and shape enable them to behave as novel scaffolds for DNA binding.
A monumental schola discovered on the Boulevard Frédéric-Latouche in Augustodunum/Autun (Saône-et-Loire)
2013
In 2011, an archaeological evaluation was carried out in the centre of the Roman city of Augustodunum (Autun) on a plot of over 1 ha. This operation afforded the opportunity to explore parts of two insulae along the main street, the so-called cardo maximus, an area that has benefited from recent advances in knowledge. The first insula hosts a high-status domus strongly resembling those of "Balbius Iassus" and the "Étui d’Or", excavated in the vicinity in the 1970s; the second, addressed in this paper, contains the remains of a vast monumental complex covering approximately 900 m2. Most probably built at the beginning of the 2nd c. on the ruins of earlier houses, it was thoroughly restructur…
Antitumor Cell-Complex Vaccines Employing Genetically Modified Tumor Cells and Fibroblasts
2014
The present study evaluates the immune response mediated by vaccination with cell complexes composed of irradiated B16 tumor cells and mouse fibroblasts genetically modified to produce GM-CSF. The animals were vaccinated with free B16 cells or cell complexes. We employed two gene plasmid constructions: one high producer (pMok) and a low producer (p2F). Tumor transplant was performed by injection of B16 tumor cells. Plasma levels of total IgG and its subtypes were measured by ELISA. Tumor volumes were measured and survival curves were obtained. The study resulted in a cell complex vaccine able to stimulate the immune system to produce specific anti-tumor membrane proteins (TMP) IgG. In the g…
Disrupting neural activity related to awake-state sharp wave-ripple complexes prevents hippocampal learning
2012
Oscillations in hippocampal local-field potentials (LFPs) reflect the crucial involvement of the hippocampus in memory trace formation: theta (4–8 Hz) oscillations and ripples (~200 Hz) occurring during sharp waves are thought to mediate encoding and consolidation, respectively. During sharp wave-ripple complexes (SPW-Rs), hippocampal cell firing closely follows the pattern that took place during the initial experience, most likely reflecting replay of that event. Disrupting hippocampal ripples using electrical stimulation either during training in awake animals or during sleep after training retards spatial learning. Here, adult rabbits were trained in trace eyeblink conditioning, a hippoc…
Structure ofD-ribonic acid-dimethyltin(IV) in coordinating solvents: an experimental and DFT119Sn NMR study
2006
We have investigated a newly synthesized complex of D-ribonic acid with dimethyltin(IV). The structure of the complex in solution has been characterized by means of 1 H, 13 C, and 119 Sn NMR and by DFT calculations. The comparison of experimental and computational results allowed the determination of the stable conformation in solution as well as the detection of a dimerization process. Moreover, evidence is given of active coordination of the metal by the solvent.