Search results for "connective tissue disease"
showing 10 items of 874 documents
Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor
2020
Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …
SARS-COV-2 PANDEMIC IN THE MEDITERRANEAN AREA: EPIDEMIOLOGY AND PERSPECTIVES
2020
In December 2019, a disease caused by a novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was identified in Wuhan, Hubei Province, China. In March 2020, the World Health Organization declared the pandemic due to SARS-CoV-2. At the end of May 2020, SARS-CoV-2 confirmed cases and deaths due to novel Coronavirus disease (COVID-19) were about 6.5 million and 380,000, worldwide. In this commentary the authors argue on the impact of SARS-CoV-2 pandemic in different epidemiological settings within the Mediterranean area, discussing any possible association with higher or lower virus spread according to climatic factors, pollutants, characteristics of general population, and organi…
Effects of a School-Based Intervention on Motivation for Out-of-School Physical Activity Participation
2021
Purpose: We tested the effects of an autonomy-supportive intervention in physical education (PE) on high-school students’ autonomous motivation in PE, and their autonomous motivation, intentions, and physical activity (PA) behavior in a leisure time guided by the trans-contextual model. Method: PE classes in two schools were assigned to receive either an autonomy-supportive intervention and/or a control intervention via random allocation by the school. The PE teacher of the school assigned to the autonomy-supportive intervention was trained to provide autonomy support while the PE teacher of the school assigned to the control intervention received no training. Students (N = 256) in all clas…
Toxic microalgae and global change : why have proliferations increased along the Mediterranean coast?
2021
The ocean and the continent converge in a very narrow line that is, nonetheless, truly relevant to the health, leisure, and economy of our society. The Mediterranean coastline has undergone major changes over the last fifty years, which is evident in the alteration of its microalgae species. The proliferation of dinoflagellates is now common in microscopic organism communities in this ecosystem as a result of the modifications caused by humans and climate change. The increased frequency with which toxic microalgae blooms are detected has been key to raising awareness of this change.
Additional file 5 of Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
2020
Additional file 5. Change in clinical and biological parameters between day 0 and week 6 for FMT and sham treatment groups.
THE HUMAN RESOURCES MANAGER - A MODERATOR FACTOR OF THE ORGANIZATIONAL CHANGE
2012
The main purpose of this article is to establish the role that the managers of human resources play in the coordination of the organizational change. In this context are analyzed the managers’ report regarding the changing factors.
Roles of adenosine and cytosine methylation changes and genetic mutations in adaptation to different temperatures
2019
Abstract Epigenetic modifications have been found to be involved in evolution, but the relative contributions of genetic and epigenetic variation in adaptation are unknown. Furthermore, previous studies on the role of epigenetic changes in adaptation have nearly exclusively focused on cytosine methylation in eukaryotes. We collected phenotypic, genetic, and epigenetic data from populations of the bacterium Serratia marcescens that had undergone experimental evolution in contrasting temperatures to investigate the relationship between environment, genetics, epigenetic, and phenotypic traits. The genomic distribution of methylated adenosines (m6A) pointed to their role in regulation of gene e…
MOESM1 of Longitudinal association of changes in diet with changes in body weight and waist circumference in subjects at high cardiovascular risk: th…
2019
Additional file 1: Figure S1. Flow chart summarizing selection of PREDIMED participants for the present study. Figure S2. Directed acyclic graph (DAG). Table S1. Characterization of food items belonging to each food group. Table S2. Correlations matrix between food groups (serving/d) within each global dietary score (GDS). Table S3. Sensitivity analyses: Association of yearly changes in food groups intake with concurrent changes in waist circumference over 5-year of follow-up by sex. Table S4. Sensitivity analysis: association of changes in global dietary score (GDS) with body weight and waist circumference changes over 5-year of follow-up. Table S5. Sensitivity analysis: association of cha…
Additional file 1 of The effects of rapid weight loss on skeletal muscle in judo athletes
2020
Additional file 1. Changes in body weight and biomarkers.
Additional file 1: of Identification of key genes and its chromosome regions linked to drought responses in leaves across different crops through met…
2019
Table S1. The table consists of gene_ID, corresponding arabidopsis orthologs and log2 fold change values for significantly regulated genes (FDRâ