Search results for "consort"

A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

2011

Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene–environment interactions for circulating lipids has been reported. We screened for variants that modify the relationship between known epidemiological risk factors and circulating lipid levels in a meta-analysis of genome-wide association (GWA) data from 18 population-based cohorts with European ancestry (maximum N = 32,225). We collected 8 further cohorts (N = 17,102) for replication, and rs6448771 on 4p15 demonstrated genome-wide significant interaction with waist-to-hip-ratio (WHR) on …

Defining the role of common variation in the genomic and biological architecture of adult human height

2014

Item does not contain fulltext Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated approximately 2,000, approximately 3,700 and approximately 9,500 SNPs explained approximately 21%, approximately 24% and approximately 29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes…

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

2015

G.B. and S.N. acknowledge funding support for this work from the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. P.H.L. is supported by US National Institute of Mental Health (NIMH) grant K99MH101367. Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an an…

A New Evangelization in the life of the family and the church

2018

The Church is at all times guiding the truth and credibility of the Gospel. Reflecting on the role of the New Evangelization in the family, it is worth stopping at the concept and meaning of the family. The family is holy, as St. John Paul II is a place where life is properly protected and can develop. The family is a community of people who aspires to eternal life. In Christian terms, the family is a community of parents and children built on the relationship of man and woman. As the Dogmatic Constitution on the Church of Lumen Gentium emphasizes, the family is referred to as the home church. This is where the functions of the Church are fulfilled: priesthood, royal and prophetic.

Possible nitrogen fertilization of the early Earth Ocean by microbial continental ecosystems

2018

While significant efforts have been invested in reconstructing the early evolution of the Earth’s atmosphere–ocean–biosphere biogeochemical nitrogen cycle, the potential role of an early continental contribution by a terrestrial, microbial phototrophic biosphere has been largely overlooked. By transposing to the Archean nitrogen fluxes of modern topsoil communities known as biological soil crusts (terrestrial analogs of microbial mats), whose ancestors might have existed as far back as 3.2 Ga ago, we show that they could have impacted the evolution of the nitrogen cycle early on. We calculate that the net output of inorganic nitrogen reaching the Precambrian hydrogeological system could hav…

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

2011

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may p…

Glorioso desēpeño de los mas illustres nombres de Maria y Ana, manifestado en las heroycas acciones de la mas Excelsa Reyna de España D. Mariana d…

1696

Port. amb orla tip. Caplletres ornades, vinyeta Sign.: œ4, œ2, A-D4, E2 Text amb notes marginals Reclams

Oración fúnebre que en las exequias de la Reyna nuestra señora doña María Isabel de Braganza celebradas por el Real Acuerdo de la Audiencia de Valenc…

Grav. calc. en f. de làm.: Dibujado por F. Royo; grabado por T. Rocafort en Val. 1819 Text a 1 col. - Notes a peu de p Sign.: [A]-F4, G2

Relacion de las exequias, que la Real Universidad de Valencia celebrò à la gloriosa memoria de la Serenissima Reyna de España Doña Mariana de Neoburg…

Sign.: A-G4, H2 Text a 1 col. - Postil·les. - Reclams Port. amb orla tip Frisos, vinyetes, caplletres ornades, asteriscos, filets

Wooden biochar as a carrier for endophytic isolates

2017

Abstract Plant growth promoting microorganisms (PGPM) serve as a basis for bio-fertilizers. The aim of this study was to evaluate the wood-derived biochar as a potential carrier for PGPM, previously isolated from plants. The selected microbial consortium was compatible with aged biochar obtained from tree branches and processed at temperatures of 600–800 °C. The effect of the consortium or biochar alone and biochar carrier-based bio-formulation on plant growth was estimated in a 14-day greenhouse experiment with barley. The length of shoots and roots increased by 46% and 32% respectively in comparison with control. Synergy of consortium with biochar was observed regarding root length. Conso…