Search results for "contract"
showing 10 items of 1719 documents
Polyunsaturated fatty acids in cultured cardiomyocytes : effect on physiology and beta-adrenoceptor function
1992
This study was carried out to investigate the influence of the membrane fatty acid composition on the basal electrical and contractile activities and the response to beta-adrenergic stimulation of rat cardiac muscle cells in culture. Cells were grown for 3 days in a conventional serum culture medium and then incubated for 24 h in synthetic media containing either n-6 or n-3 as the sole source of polyunsaturated fatty acids (PUFA). The n-6/n-3 ratio in the phospholipids was 0.9 in the n-3 cells and 13.1 in the n-6 cells compared with 6.3 in controls cells. Such modifications did not alter action potentials and the main parameters related to contraction, although shortening was slightly acce…
Study on the histamine-like activity of guanfacine
1990
Abstract The effects of guanfacine have been studied on guinea-pig isolated atria and diethylstilboestrol-treated rat isolated uterus to determine whether it possesses histamine-like activity. Guanfacine produced a concentration-dependent negative chronotropic effect which was not modified by ranitidine (0.1 μM). In rat isolated uterus contracted by KCl, clonidine (5–5000 μM) produced concentration-dependent relaxation which was blocked by ranitidine (0.1 μM), but guanfacine only produced relaxation at high concentrations (100–1000 μM), and this was not affected by ranitidine (0.1 μM). It is concluded that guanfacine, unlike clonidine, does not produce effects due to activation of H2-recept…
Effects of the Phosphodiesterase Inhibitor Enoximone on the Autonomic Innervation of the Isolated Heart
1989
Enoximone is a selective inhibitor of a low Km, cyclic AMP-specific type of phosphodiesterase (PDE III). In guinea pig and chicken atria, enoximone (0.1-100 mumol/L) caused a weak increase in the force of contraction. The heart rate was slightly enhanced or was unchanged (chicken). Enoximone (30 mumol/L) also failed to shift the concentration-response curves for the positive inotropic and chronotropic effects of norepinephrine in guinea pig atria. Under almost the same conditions, enoximone and the nonselective PDE inhibitor 3-isobutyl-1-methylxanthine (IBMX) markedly potentiated the forskolin-induced mobilization of choline from phospholipids. The concentrations of IBMX (100 mumol/L) and o…
Ouabain enhances release of acetylcholine in the heart evoked by unilateral vagal stimulation.
1986
The aim of the study was to elucidate peripheral effects of ouabain on the parasympathetic innervation of the heart, effects that could contribute to the experimentally and clinically well established “vagal effect of cardiac glycosides”. The experiments were carried out with ouabain concentrations of 3×10−7 and 10−6 mol/l, which were considered “therapeutic”, as they increased force of contraction and did not elicit arrhythmias in incubated chicken atria. In atrial preparations of chickens and guinea-pigs the negative chronotropic and inotropic effects of acetylcholine (ACh) were not altered by 3×10−7 mol/l ouabain. Resting efflux of ACh from perfused chicken hearts was increased by ouabai…
The intervention of broker or alfarrassador in the Valencian agrarian contracts
2015
El artículo analiza la Ley valenciana 3/2013, que introduce una completa regulación de la figura del corredor o alfarrassador como persona que habitualmente interviene en la contratación agraria. This paper analyzes the Valencian Law 3/2013, that introduces a complete regulation of broker or alfarrassador figure, as person who habitually intervenes in the agrarian contracts.
Argumentación, arbitraje y arbitrariedad: las contradicciones del Tribunal Constitucional en el recurso directo de nulidad contra laudos.
2013
Este artículo analiza una sentencia del Tribunal Constitucional de Bolivia desde el punto de vista de la argumentación de las decisiones judiciales. En ella, el Tribunal sostuvo que las pretensiones de nulidad contractual no eran materia arbitrable. A este artículo no le concierne el fondo de esta afirmación, sino las implicancias de la misma respecto a los anteriores precedentes del propio Tribunal Constitucional. En este sentido, el artículo concluye que, para dictar la sentencia en análisis, el Tribunal ha violado sus propios precedentes respecto al recurso directo de nulidad (que es el recurso específico que produjo la sentencia en comento), respecto a la licitud de someter pretensiones…
Some new fixed point results in non-Archimedean fuzzy metric spaces
2013
In this paper, we introduce the notions of fuzzy $(\alpha,\beta,\varphi)$-contractive mapping, fuzzy $\alpha$-$\phi$-$\psi$-contractive mapping and fuzzy $\alpha$-$\beta$-contractive mapping and establish some results of fixed point for this class of mappings in the setting of non-Archimedean fuzzy metric spaces. The results presented in this paper generalize and extend some recent results in fuzzy metric spaces. Also, some examples are given to support the usability of our results.
Clause de fixation du prix a dire de tiers. Contrat de bail. Qualification, Clause d'arbitrage (non), Caractère contractuel de l'estimation
1998
International audience; (Cass. 3e civ., 4 mars 1998, Melleret c/ Laurent Pinsonnet, RJDA 5/1998, n° 662)
Problemática laboral de los socios trabajadores de las empresas de Economía Social: ¿socios o trabajadores?
1999
Co-operatives and labour societies are the most important organisations within the framework of Social Economy. The establishment of these societies, which create employment in the private sector with a democratic philosophy based on mutual help, has been recently boosted thanks to the support of public power. Their growing importance can be explained by three factors: the Employment Policy, the Social Policy and the productive decentralisation. As far as labour is concerned, these societies offer the following advantages: intensive use of labour, high rate of stability in employment, high levels of productivity, training and surplus re-inversion, lower rate of inflation, fewer conflicts th…
L’adempimento in natura alla luce della riforma del code civil
2018
Il code civil riformato ha integralmente riscritto la disciplina dell’inexécution du contrat, tra le altre cose riconoscendo espressamente il rimedio dell’adempimento in natura, ossia l’exécution forcée en nature, e riservandogli una compiuta disciplina. Così è stato possibile superare l’angusta formulazione originaria del code civil in materia e recepire nel codice soluzioni che, nonostante le indicazioni di segno contrario offerte dalla sua precedente versione, si erano lentamente affermate tanto in dottrina quanto in giurisprudenza, anche per effetto degli influssi provenienti dagli altri sistemi giuridici continentali e dal diritto privato europeo. L’illustrazione del nuovo sistema fran…