Search results for "copd"

showing 10 items of 483 documents

TLR4 upregulation underpins airway neutrophilia in smokers with chronic obstructive pulmonary disease and acute respiratory failure

2010

Activation of Toll-like receptors (TLR) seems to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Upon TLR activation the release of defensins, including human beta defensin 2 (HBD-2), may occur. In this study, we explored the innate responses in patients with respiratory failure, with and without COPD, requiring intubation and mechanical ventilation. Mini-bronchoalveolar lavage (mini-BAL) samples were collected from nonsmoker subjects without COPD (n = 10), smokers without COPD (n = 6), and smokers with COPD (n = 15). TLR4, TLR2, and HBD-2 expression was evaluated by immunocytochemistry; interleukin (IL)-8, IP-10, and HBD-2 concentrations were evaluated by e…

MaleChemokinebeta-DefensinsLeukocytosisNeutrophilsLymphocyteImmunologySettore MED/41 - AnestesiologiaApoptosisPathogenesisPulmonary Disease Chronic ObstructivemedicineHumansImmunology and AllergyAgedAged 80 and overCOPDTUNEL assaybiologybusiness.industryChemotaxisInterleukin-8SmokingAcute Lung Injury COPD TLR4InterleukinGeneral Medicinemedicine.diseaseToll-Like Receptor 2Neutrophiliarespiratory tract diseasesToll-Like Receptor 4medicine.anatomical_structureTerminal deoxynucleotidyl transferaseAcute DiseaseImmunologybiology.proteinFemalemedicine.symptomRespiratory InsufficiencybusinessBronchoalveolar Lavage FluidHuman Immunology
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Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study

2019

Abstract Background Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HR-QoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype. Methods The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was made by clinicians at enrollment. Baseline e…

MaleChronic bronchitisTime FactorsHealth StatusAnxietyHospital Anxiety and Depression ScaleSeverity of Illness IndexHealth StatuPulmonary Disease Chronic Obstructive0302 clinical medicineSurveys and QuestionnairesForced Expiratory VolumeClinical phenotypeMedicineSurveys and QuestionnaireRespiratory function030212 general & internal medicineProspective StudiesProspective cohort studyLungDepression (differential diagnoses)COPDDepressionMiddle AgedCircadian RhythmPhenotypeItalyAnxietyFemalemedicine.symptom24-hour symptoms Clinical phenotype Real-world Respiratory functionResearch ArticleHumanPulmonary and Respiratory Medicinemedicine.medical_specialtyChronic ObstructiveTime FactorSettore MED/10 - Malattie Dell'Apparato RespiratorioPulmonary Disease03 medical and health sciencesInternal medicineHumansAsthma24-hour symptoms; Clinical phenotype; Real-world; Respiratory function; Aged; Anxiety; Depression; Female; Forced Expiratory Volume; Health Status; Humans; Italy; Lung; Male; Middle Aged; Phenotype; Prospective Studies; Pulmonary Disease Chronic Obstructive; Severity of Illness Index; Sleep; Surveys and Questionnaires; Time Factors; Circadian Rhythm; Quality of LifeAgedlcsh:RC705-77924-hour symptomsbusiness.industryCorrectionlcsh:Diseases of the respiratory systemmedicine.disease24-hour symptomProspective Studie030228 respiratory systemReal-worldQuality of LifebusinessSleepRespiratory function
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The influence of smoking status on exhaled breath profiles in asthma and COPD patients

2021

Breath analysis using eNose technology can be used to discriminate between asthma and COPD patients, but it remains unclear whether results are influenced by smoking status. We aim to study whether eNose can discriminate between ever- vs. never-smokers and smoking &lt

MaleCopd patientsPharmaceutical ScienceeNoseAnalytical ChemistryPulmonary Disease Chronic Obstructive0302 clinical medicineDrug DiscoveryElectronic Nose0303 health sciencesCOPDConfoundingfood and beveragesMiddle AgedBreath Testsexhaled breathChemistry (miscellaneous)ExhalationMolecular MedicineSmoking statusFemaleAdultmedicine.medical_specialtySmoking habitPulmonary diseaseSettore MED/10 - Malattie Dell'Apparato RespiratorioArticlesmokinglcsh:QD241-44103 medical and health scienceslcsh:Organic chemistryInternal medicinemedicineHumansCOPDPhysical and Theoretical Chemistry030304 developmental biologyAsthmaVolatile Organic Compoundsbusiness.industryfungiOrganic Chemistryasthmamedicine.diseaserespiratory tract diseasesCross-Sectional Studies030228 respiratory systemBreath gas analysisROC CurveAsthma COPD eNose Exhaled breath SmokingCase-Control Studiesbusiness
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Effects of long-acting bronchodilators in COPD patients according to COPD severity and ICS use

2013

SummaryBackgroundIndacaterol is a once-daily, long-acting β2-agonist bronchodilator that improves dyspnoea and health status in patients with moderate-to-severe COPD. While its bronchodilator effects have been shown to be maintained in different patient subgroups, effects on clinical outcomes in certain subgroups are not yet defined.MethodsPost-hoc analysis of pooled clinical study data to investigate efficacy and safety of indacaterol compared with placebo and other long-acting bronchodilators (formoterol, salmeterol, open-label tiotropium) in patient subgroups defined by COPD severity (GOLD stage II or III; n = 4082) and ICS use at baseline (no/yes; n = 4088). Efficacy outcomes were troug…

MaleCopd patientsVital CapacityQuinolonesSeverity of Illness IndexPulmonary Disease Chronic ObstructiveForced Expiratory VolumeFormoterol FumarateBronchodilatorFormoterolSalmeterolSalmeterol XinafoateRandomized Controlled Trials as TopicIndacaterolCOPDMiddle AgedBronchodilator AgentsTreatment OutcomeEthanolaminesAnesthesiaIndansDrug Therapy CombinationFemaleSalmeterolmedicine.drugAdultPulmonary and Respiratory Medicinemedicine.medical_specialtymedicine.drug_classScopolamine DerivativesPlaceboDrug Administration ScheduleInternal medicineAdministration InhalationmedicineHumansCOPDAlbuterolTiotropium BromideAdrenergic beta-2 Receptor AgonistsGlucocorticoidsAgedbusiness.industryTiotropiummedicine.diseaserespiratory tract diseasesDyspneaLong actingIndacaterolFormoterolbusinessRespiratory Medicine
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High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non-inferiority randomized…

2020

Abstract Background The efficacy and safety of high flow nasal therapy (HFNT) in patients with acute hypercapnic exacerbation of chronic obstructive pulmonary disease (AECOPD) are unclear. Our aim was to evaluate the short-term effect of HFNT versus NIV in patients with mild-to-moderate AECOPD, with the hypothesis that HFNT is non-inferior to NIV on CO2 clearance after 2 h of treatment. Methods We performed a multicenter, non-inferiority randomized trial comparing HFNT and noninvasive ventilation (NIV) in nine centers in Italy. Patients were eligible if presented with mild-to-moderate AECOPD (arterial pH 7.25–7.35, PaCO2 ≥ 55 mmHg before ventilator support). Primary endpoint was the mean di…

MaleExacerbationEquivalence Trials as TopicCritical Care and Intensive Care MedicineAcute respiratory failurelaw.invention03 medical and health sciencesPulmonary Disease Chronic Obstructive0302 clinical medicineRandomized controlled triallawClinical endpointmedicineHumansCannulaAcute respiratory failure; Chronic obstructive pulmonary disease; High flow nasal cannula; High flow nasal therapy; Noninvasive ventilation030212 general & internal medicineHigh flow nasal therapyAgedCOPDbusiness.industryResearchhigh flow oxygen therapy high flow nasal cannula noninvasive ventilation COPD carbon dioxide acute respiratory failureChronic obstructive pulmonary diseaselcsh:Medical emergencies. Critical care. Intensive care. First aidOxygen Inhalation Therapylcsh:RC86-88.9Middle Agedmedicine.diseaseSymptom Flare UpConfidence intervalHigh flow nasal cannula030228 respiratory systemItalyAnesthesiaBreathingNoninvasive ventilationFemaleHigh flowbusinessNoninvasive ventilationHuman
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Functional and Prognostic Implications of the Main Pulmonary ArteryDiameter to Aorta Diameter Ratio from Chest Computed Tomography inKorean COPD Pati…

2016

Background The ratio of the diameter of the main pulmonary artery (mPA) to the diameter of the aorta (Ao) on chest computed tomography is associated with diverse clinical conditions. Herein, we determined the functional and prognostic implications of the mPA/Ao ratio in Korean chronic obstructive pulmonary disease (COPD) patients. Methods The study population comprised 226 chronic obstructive pulmonary disease patients from the Korean Obstructive Lung Disease cohort who underwent chest computed tomography. We analyzed the relationships between the clinical characteristics, including pulmonary function, echocardiography findings, St. George's Respiratory Questionnaire, 6-minute walking (6MW)…

MaleExacerbationPulmonologyPulmonary Functionlcsh:Medicine030204 cardiovascular system & hematologyPulmonary function testingDiagnostic RadiologyPulmonary Disease Chronic Obstructive0302 clinical medicineUltrasound ImagingMedicine and Health SciencesPulmonary Arterieslcsh:ScienceTomographyAortaCOPDMultidisciplinaryRadiology and ImagingArteriesMiddle AgedPrognosisObstructive lung diseaseEchocardiographyCardiologyFemaleAnatomyResearch Articlemedicine.medical_specialtyImaging TechniquesChronic Obstructive Pulmonary DiseaseCardiologyNeuroimagingPulmonary ArteryResearch and Analysis Methods03 medical and health sciencesFEV1/FVC ratioDiagnostic MedicineInternal medicinemedicine.arteryRepublic of KoreamedicineHumansAgedEmphysemaHeart Failurebusiness.industrylcsh:RBiology and Life SciencesOdds ratiomedicine.diseaseComputed Axial Tomography030228 respiratory systemHeart failurePulmonary arteryCardiovascular AnatomyBlood Vesselslcsh:QbusinessTomography X-Ray ComputedNeuroscience
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Functional Metagenomics of the Bronchial Microbiome in COPD

2015

Altres ajuts: Sociedad Catalana de Neumología; Fundació Catalana de Neumología; Fundació Parc Tauli; Marató de TV3; Sociedad Española de Neumología y Cirugía Torácica; Fundación Menarini; Generalitat Valenciana (Spain) [Prometeo/2009/092] i Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES) The course of chronic obstructive pulmonary disease (COPD) is frequently aggravated by exacerbations, and changes in the composition and activity of the microbiome may be implicated in their appearance. The aim of this study was to analyse the composition and the gene content of the microbial community in bronchial secretions of COPD patients in both stability and exacerbati…

MaleExacerbationlcsh:MedicineCarbohydrate metabolismBiologyBioinformaticsPulmonary Disease Chronic ObstructiveRNA Ribosomal 16SmedicineHumansMicrobiomeKEGGlcsh:ScienceLungAgedCOPDMultidisciplinaryLungBacteriaMicrobiotaChronic obstructive pulmonary diseaselcsh:RSputumMiddle Agedmedicine.diseasemedicine.anatomical_structureRibosomal RNAMetagenomicsImmunologyDisease ProgressionMetagenomeSputumPyrosequencingFemalelcsh:QMicrobiomeSequence databasesMetagenomicsmedicine.symptomResearch ArticlePLOS ONE
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Hsp27 and Hsp70 in chronic obstructive pulmonary disease: certainties vs doubts

2015

Dear Editor, We read with great interest the work by Cui et al. (2015) in which they measured the levels of Hsp70 and Hsp27 in plasma and lymphocytes obtained from coal workers (CW) affected by chronic obstructive pulmonary disease (COPD) alone or associated with pneumoconiosis (CWP). They found that Hsp70 levels were higher in plasma of COPD subjects affected by CWP compared to COPD subjects without CWP and to controls. There was no difference in Hsp70 levels between COPD without CWP and controls. Hsp70 levels in lymphocytes did not show differences among the three groups. The authors found lower levels of Hsp27 in plasma from patients when comparing controls to both COPD with and without …

MaleHSP27 Heat-Shock ProteinLymphocytemedicine.medical_treatmentPopulationHSP27 Heat-Shock ProteinsBiochemistryPathogenesisPulmonary Disease Chronic ObstructiveOccupational ExposureBiopsymedicineHumansHSP70 Heat-Shock ProteinsLymphocytesAnthracosieducationLetter to the EditorAnthracosisHSP70 Heat-Shock ProteinLamina propriaCOPDeducation.field_of_studyLungmedicine.diagnostic_testbusiness.industryCell Biologymedicine.diseaseCoal Miningrespiratory tract diseasesCoalmedicine.anatomical_structureCytokineImmunologyLymphocytebusinessHumanCell Stress and Chaperones
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Disease awareness in patients with COPD: measurement and extent

2018

Ilaria Baiardini,1 Paola Rogliani,2 Pierachille Santus,3 Angelo G Corsico,4 Marco Contoli,5 Nicola Scichilone,6 Fabiano Di Marco,7 Patrizia Lessi,8 Carla Scognamillo,8 Giorgia Molinengo,9 Fabio Ferri,10 Vincenzo Patella,11 Giuseppe Fiorentino,12 Mauro Carone,13 Fulvio Braido14 1Department of Biomedical Sciences, Humanitas University, Milan, Italy; 2Respiratory Unit, Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy; 3Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, Milan, Italy; 4Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; 5Department of Medical Sciences, University of F…

MaleHealth Knowledge Attitudes PracticeTime Factorspatient satisfactionSettore MED/10 - Malattie dell'Apparato RespiratorioDiseaseSeverity of Illness IndexPulmonary Disease Chronic Obstructive0302 clinical medicineCost of IllnessSurveys and QuestionnairesActivities of Daily Living80 and overawareness030212 general & internal medicineLungIllness BehaviorAged 80 and overPracticeCOPDHealth PolicyHealth KnowledgeGeneral MedicineMiddle AgedItalyFemalePublic HealthPulmonary and Respiratory MedicineChronic Obstructivemedicine.medical_specialtySocio-culturaleInternational Journal of Chronic Obstructive Pulmonary DiseasePulmonary DiseaseTreatment satisfactionIllness perceptions03 medical and health sciencesNegatively associatedAwareness; COPD; Patient satisfaction; Questionnaire; Activities of Daily Living; Aged; Aged 80 and over; Cost of Illness; Dyspnea; Female; Humans; Illness Behavior; Italy; Lung; Male; Middle Aged; Patient Compliance; Patient Satisfaction; Pulmonary Disease Chronic Obstructive; Reproducibility of Results; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Awareness; Health Knowledge Attitudes Practice; Patient Acceptance of Health CaremedicineHumansCOPDIn patientAgedlcsh:RC705-779business.industryquestionnaireEnvironmental and Occupational HealthPublic Health Environmental and Occupational HealthAwareneReproducibility of Resultslcsh:Diseases of the respiratory systemPatient Acceptance of Health Caremedicine.diseaseCOPD; awareness; patient satisfaction; questionnaireawareness; COPD; patient satisfaction; questionnaire; Pulmonary and Respiratory Medicine; Health Policy; Public Health Environmental and Occupational HealthClinical trialDyspnea030228 respiratory systemClinical Trial ReportAttitudesPhysical therapyPatient CompliancePatient awarenessbusiness
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Increased levels of Th17 cells are associated with non-neuronal acetylcholine in COPD patients.

2014

T-lymphocytes, including Th17-cells and T-cells expressing acetylcholine (ACh), are key components of systemic inflammation in chronic obstructive pulmonary disease (COPD). We investigated whether ACh promotes Th17 cells in COPD. ACh, IL-17A, IL-22, RORγt, FOXP3 expression and AChIL-17A, AChIL-22, AChRORγt coexpression was evaluated in peripheral blood mononuclear cells (PBMC) from COPD patients (n=16), healthy smokers (HS) (n=12) and healthy control subjects (HC) (n=13) (cultured for 48 h with PMA) by flow cytometry. Furthermore, we studied the effect of Tiotropium (Spiriva®) (100 nM) and Olodaterol (1nM) alone or in combination, and of hemicholinium-3 (50 μM) on AChIL-17A, AChIL-22, AChRO…

MaleImmunologyIntracellular SpaceScopolamine DerivativesPharmacologySystemic inflammationPeripheral blood mononuclear cellCholinergic AntagonistsFlow cytometrychemistry.chemical_compoundPulmonary Disease Chronic ObstructiveRAR-related orphan receptor gammaRisk FactorsmedicineImmunology and AllergyHumansTiotropium BromideAgedAged 80 and overCOPDmedicine.diagnostic_testbusiness.industryInterleukinsOlodaterolInterleukin-17FOXP3Forkhead Transcription FactorsHematologyMiddle AgedNuclear Receptor Subfamily 1 Group F Member 3medicine.diseaseAcetylcholineBenzoxazineschemistryLeukocytes MononuclearTh17 CellsFemalemedicine.symptombusinessAcetylcholinemedicine.drugImmunobiology
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