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RESEARCH PRODUCT
Functional and Prognostic Implications of the Main Pulmonary ArteryDiameter to Aorta Diameter Ratio from Chest Computed Tomography inKorean COPD Patients
Kyung Soo ChungYoung Sam KimSe Kyu KimHa Yan KimSang Min LeeJoon Beom SeoYeon Mok OhJi Ye JungSang-do LeeKorean Obstructive Lung Disease Study Groupsubject
MaleExacerbationPulmonologyPulmonary Functionlcsh:Medicine030204 cardiovascular system & hematologyPulmonary function testingDiagnostic RadiologyPulmonary Disease Chronic Obstructive0302 clinical medicineUltrasound ImagingMedicine and Health SciencesPulmonary Arterieslcsh:ScienceTomographyAortaCOPDMultidisciplinaryRadiology and ImagingArteriesMiddle AgedPrognosisObstructive lung diseaseEchocardiographyCardiologyFemaleAnatomyResearch Articlemedicine.medical_specialtyImaging TechniquesChronic Obstructive Pulmonary DiseaseCardiologyNeuroimagingPulmonary ArteryResearch and Analysis Methods03 medical and health sciencesFEV1/FVC ratioDiagnostic MedicineInternal medicinemedicine.arteryRepublic of KoreamedicineHumansAgedEmphysemaHeart Failurebusiness.industrylcsh:RBiology and Life SciencesOdds ratiomedicine.diseaseComputed Axial Tomography030228 respiratory systemHeart failurePulmonary arteryCardiovascular AnatomyBlood Vesselslcsh:QbusinessTomography X-Ray ComputedNeurosciencedescription
Background The ratio of the diameter of the main pulmonary artery (mPA) to the diameter of the aorta (Ao) on chest computed tomography is associated with diverse clinical conditions. Herein, we determined the functional and prognostic implications of the mPA/Ao ratio in Korean chronic obstructive pulmonary disease (COPD) patients. Methods The study population comprised 226 chronic obstructive pulmonary disease patients from the Korean Obstructive Lung Disease cohort who underwent chest computed tomography. We analyzed the relationships between the clinical characteristics, including pulmonary function, echocardiography findings, St. George's Respiratory Questionnaire, 6-minute walking (6MW) distance, and exacerbation with the mPA, Ao, and mPA/Ao ratio. Results The mean age was 65.8 years, and 219 (96.9%) patients were male. The mean FEV1% predicted and FEV1/FVC ratio were 61.2% and 47.3%, respectively. The mean mPA and Ao were 23.7 and 36.4 mm, respectively, and the mPA/Ao ratio was 0.66. The mPA/Ao ratio correlated negatively with the 6MW distance (G = -0.133, P = 0.025) and positively with the right ventricular pressure (G = 0.323, P = 0.001). After adjustment for potential confounders, the mPA/Ao ratio was significantly associated with 6MW distance (β = -107.7, P = 0.017). Moreover, an mPA/Ao ratio >0.8 was a significant predictor of exacerbation at the 1-year (odds ratio 2.12, 95% confidence interval 1.27–3.52) and 3-year follow-ups (odds ratio 2.04, 95% confidence interval 1.42–2.90). Conclusions The mPA/Ao ratio is an independent predictor of exercise capacity and an mPA/Ao ratio >0.8 is a significant risk factor of COPD exacerbation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 |