Search results for "corpus"
showing 10 items of 698 documents
Case of unilateral wing formation in the female of the glowwormLampyris noctiluca
2003
On July 27, 1999, the first author found a unilaterally winged adult glowworm in a park in the city of Mainz. Except for the wings on the left side, the specimen exhibited female characteristics that extended to external sexual appendages, the lantern and the gonads. The internal organization showed some remarkable differences between right (wingless) and left (winged) side. The right ovary contained three times more mature eggs than the left side and the volume of the corpus allatum of this side was about one-third larger than that of the left side. This suggests that aptery and egg maturation are affected by corpus allatum activity, i.e., juvenile hormone production. The findings do not s…
Mesurer l’efficacité des enseignements par l’étude des rendements
2021
International audience; Le champ des recherches concernant les pratiques enseignantes en étude de la langue demeure peu fertile (on citera entre autres : Bulea Bronckart et al. , 2018 ; Riou, 2017) et supporte peu de généralisations, la portée statistique semblant difficilement atteignable, pour des raisons pragmatiques. Par ailleurs, l’importante recherche Lire – Écrire menée par l’Ifé en 2010-2013 (Goigoux, 2015) a ouvert la voie méthodologique à des études quantitatives dans le domaine de la didactique. C’est dans ce cadre que la recherche REAlang1 s’est donné comme objectif, entre autres, d’évaluer la performance des classes de CE2, CM1 et CM22 concernant des savoirs grammaticaux et ort…
Cloning and characterization of the phenylalanyl-tRNA synthetase β subunit gene fromCandida albicans
1998
A Candida albicans expression library was constructed from RNA isolated from regenerating protoplasts. A 1.4-kb cDNA clone was used to isolate a genomic fragment. Sequence analysis revealed an open reading frame of 593 amino acids with an overall identity of 63.6% with the phenylalanyl-tRNA synthetase beta subunit (FRS1) of Saccharomyces cerevisiae. We named it CaFRS1. It is located in a single copy in chromosome R, SfiI fragment M. Its expression showed a decrease during the cell wall regeneration process in protoplasts of both yeast and mycelial cells of C. albicans, suggesting its requirement thereof in initial steps of the cell wall synthesis.
Autour du corpus « Brochures de la Bibliothèque marxiste de Paris »
2014
International audience
Discours Numériques : Quels enjeux pour la linguistique (appliquée) ?
2017
International audience; L'exposé est consacré à une présentation des enjeux potentiels, pour la recherche en linguistique (appliquée), du traitement, aussi par les industries de la langue, de nouveaux types de corpus numériques issus de l'essor des TIC. A partir de trois projets en cours à la MSH de Dijon, la partie centrale discute des besoins en recherche linguistique fondamentale qui émergent de ces nouvelles problématiques.
Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy
2013
Vici syndrome is a recessively inherited multisystem disorder characterized by callosal agenesis, cataracts, cardiomyopathy, combined immunodeficiency and hypopigmentation. To investigate the molecular basis of Vici syndrome, we carried out exome and Sanger sequence analysis in a cohort of 18 affected individuals. We identified recessive mutations in EPG5 (previously KIAA1632), indicating a causative role in Vici syndrome. EPG5 is the human homolog of the metazoan-specific autophagy gene epg-5, encoding a key autophagy regulator (ectopic P-granules autophagy protein 5) implicated in the formation of autolysosomes. Further studies showed a severe block in autophagosomal clearance in muscle a…
Protective action of 1,3-butanediol in cerebral ischemia. A neurologic, histologic, and metabolic study.
1987
1,3-Butanediol (BD) is converted in the body to β-hydroxybutyrate, and previous studies have shown that hyperketonemia had beneficial effects in experimental models of generalized hypoxia. The aim of this study was to determine if BD would reduce brain damage following cerebral ischemia. A transient forebrain ischemia of 30-min duration was induced by the four-vessel occlusion technique in control and BD-treated rats (25 mmol/kg, i.p.; 30 min prior to ischemia). BD treatment led to significant improvement of neurologic deficit during the 72-h recovery period and reduced neuronal damage in the striatum and cortex but not in the CA1 sector of the hippocampus. Evaluation of cerebral energy me…
Neuroprotective effect of erythropoietin and darbepoetin alfa after experimental intracerebral hemorrhage.
2009
OBJECTIVE: Intracerebral hemorrhage (ICH) is a devastating clinical syndrome for which no truly efficacious therapy has yet been identified. In preclinical studies, erythropoietin (EPO) and its long-lasting analog, darbepoetin alfa, have been demonstrated to be neuroprotective in several models of neuronal insult. The objectives of this study were to analyze whether the systemic administration of recombinant human EPO (rHuEPO) and its long-lasting derivative darbepoetin alfa expedited functional recovery and brain damage in a rat model of ICH. METHODS: Experimental ICH was induced in rats by injecting autologous blood into the right striatum under stereotactic guidance. Subsequently, animal…
Peindre à Auxerre aux IXe-XIVe siècles. 10 ans de recherche à l'abbaye Saint-Germain d'Auxerre et à la cathédrale Saint-étienne d'Auxerre
1999
International audience
Impaired immune response to Candida albicans in aged mice
2006
The prevalence of opportunistic fungal infections has increased dramatically among the aged population in recent years. This work investigated the effect of ageing on murine defences against Candida albicans. Aged C57BL/6 mice that were experimentally infected intravenously had a significantly impaired survival and a higher tissue fungal burden compared with young mice. In vitro production of tumour necrosis factor (TNF)-α by macrophages from aged mice in response to yeast cells and hyphae of C. albicans was significantly lower than production by macrophages from young mice. In vitro production of cytokines, such as TNF-α and gamma interferon (IFN-γ), by antigen-stimulated splenocytes from …