Search results for "cover"

showing 10 items of 5959 documents

Synthesis, Stability and Relaxivity of TEEPO-Met: An Organic Radical as a Potential Tumour Targeting Contrast Agent for Magnetic Resonance Imaging

2018

Cancer is a widespread and life-threatening disease and its early-stage diagnosis is vital. One of the most effective, non-invasive tools in medical diagnostics is magnetic resonance imaging (MRI) with the aid of contrast agents. Contrast agents that are currently in clinical use contain metals, causing some restrictions in their use. Also, these contrast agents are mainly non-specific without any tissue targeting capabilities. Subsequently, the interest has notably increased in the research of organic, metal-free contrast agents. This study presents a new, stable organic radical, TEEPO-Met, where a radical moiety 2,2,6,6-tetraethylpiperidinoxide (TEEPO) is attached to an amino acid, methio…

116 Chemical sciencesPharmaceutical ScienceContrast Media01 natural sciencesAnalytical Chemistrylaw.inventionGLUCOSENuclear magnetic resonancePiperidineslawHeterocyclic CompoundsNeoplasmsDrug DiscoveryMoietymagneettitutkimusSpin labelElectron paramagnetic resonanceta116orgaaniset yhdisteetmedicine.diagnostic_testMolecular StructureChemistryPhantoms ImagingRelaxation (NMR)radicalsMagnetic Resonance Imaging3. Good healthChemistry (miscellaneous)Molecular MedicineMRIRadical010402 general chemistryvapaat radikaalitImaging phantomArticleCyclic N-OxidesvarjoainetutkimusnitroxidesmedicineAnimalsHumanscontrast agentstyppiyhdisteetPhysical and Theoretical Chemistrymethionine010405 organic chemistryOrganic ChemistryElectron Spin Resonance SpectroscopyMagnetic resonance imagingIN-VITRO3126 Surgery anesthesiology intensive care radiologynitroxides; radicals; methionine; contrast agents; MRI; NMR; EPRIn vitroNMRTRANSPORT0104 chemical sciencesREDUCTIONSPIN-LABEL1182 Biochemistry cell and molecular biologyEPRMolecules; Volume 23; Issue 5; Pages: 1034
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Snowpack concentrations and estimated fluxes of volatile organic compounds in a boreal forest

2012

Abstract. Soil provides an important source of volatile organic compounds (VOCs) to atmosphere, but in boreal forests these fluxes and their seasonal variations have not been characterized in detail. Especially wintertime fluxes are almost completely unstudied. In this study, we measured the VOC concentrations inside the snowpack in a boreal Scots pine (Pinus sylvestris L.) forest in southern Finland, using adsorbent tubes and air samplers installed permanently in the snow profile. Based on the VOC concentrations at three heights inside the snowpack, we estimated the fluxes of these gases. We measured 20 VOCs from the snowpack, monoterpenes being the most abundant group with concentrations …

1171 Geosciences010504 meteorology & atmospheric sciencesSEASONAL-VARIATIONeducationCLIMATE CHANGElcsh:LifeVOC CONCENTRATIONS010501 environmental sciences01 natural sciencesAtmosphereSMEAR-IISNOW COVERMONOTERPENE EMISSIONSlcsh:QH540-549.5medicineSCOTS PINETEMPERATUREEcology Evolution Behavior and Systematics1172 Environmental sciencesEarth-Surface Processes0105 earth and related environmental sciencesHydrologyForest floor4112 ForestrybiologyTaigalcsh:QE1-996.5Scots pine04 agricultural and veterinary sciencesSeasonalitySnowpack15. Life on landSnowmedicine.diseasebiology.organism_classificationlcsh:GeologySOILlcsh:QH501-531Boreal13. Climate actionEnvironmental chemistry040103 agronomy & agriculture0401 agriculture forestry and fisheriesEnvironmental sciencelcsh:Ecology
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Infinitesimal deformations of double covers of smooth algebraic varieties

2003

The goal of this paper is to give a method to compute the space of infinitesimal deformations of a double cover of a smooth algebraic variety. The space of all infinitesimal deformations has a representation as a direct sum of two subspaces. One is isomorphic to the space of simultaneous deformations of the branch locus and the base of the double covering. The second summand is the subspace of deformations of the double covering which induce trivial deformations of the branch divisor. The main result of the paper is a description of the effect of imposing singularities in the branch locus. As a special case we study deformations of Calabi--Yau threefolds which are non--singular models of do…

14B07; 14J3014J30Direct sum14B07General MathematicsInfinitesimalMathematical analysisAlgebraic varietySymbolic computationLinear subspaceequisingular deformationsMathematics - Algebraic GeometryMathematics::Algebraic GeometryFOS: MathematicsProjective spaceGravitational singularityLocus (mathematics)Algebraic Geometry (math.AG)double coveringsMathematics
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First synthesis of single-“strapped cyclam-porphyrins”

1994

The first synthesis of strapped cyclam porphyrins is described ; these will be studied as dioxygen carriers as well as cytochrome C oxidase models. The original derivatives are characterized by mass spectrometry and 1H NMR spectroscopy. The cofacial conformation of the two different macrocycles is confirmed by 1H NMR data.

1h nmr spectroscopybiology010405 organic chemistryStereochemistryOrganic ChemistryNuclear magnetic resonance spectroscopy010402 general chemistryMass spectrometry[ CHIM ] Chemical Sciences01 natural sciencesBiochemistry0104 chemical scienceschemistry.chemical_compoundchemistry[CHIM] Chemical SciencesDrug DiscoveryCyclamProton NMRbiology.proteinLactam[CHIM]Chemical SciencesCytochrome c oxidaseComputingMilieux_MISCELLANEOUSCyclophaneTetrahedron Letters
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Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives.

2002

Several 2,3-diaryl-1,3-thiazolidine-4-thione derivatives and 2,3-diaryl-1,3-thiazolidin-4-ones bearing a methyl group at C-5 position have been synthesized and tested as anti-HIV agents. The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication.

23-Diaryl-13-thiazolidine-4-thioneAnti-HIV activity23-Diaryl-13-thiazolidin-4-oneStereochemistryAnti-HIV AgentsCell SurvivalPharmaceutical ScienceVirus ReplicationChemical synthesischemistry.chemical_compoundInhibitory Concentration 50Structure-Activity RelationshipThiadiazolesDrug DiscoveryThiadiazolesmedicineTumor Cells CulturedStructure–activity relationshipHumansAnti hiv activityReverse-transcriptase inhibitorGeneral MedicineSettore CHIM/08 - Chimica FarmaceuticaIn vitrochemistryNNRTIsLactamHIV-1EpimerMethyl groupmedicine.drugFarmaco (Societa chimica italiana : 1989)
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NO donors. Part 16: investigations on structure-activity relationships of organic mononitrates reveal 2-nitrooxyethylammoniumnitrate as a high potent…

2007

The vasoactive properties of 14 organic mononitrates were investigated in vitro using PGF(2alpha)-precontracted porcine pulmonary arteries. A surprisingly wide range of vasorelaxant potencies was observed (pD(2): 3.36-7.50). Activities showed to be highly sensitive to the molecular structure and the substituents at the molecular carrier of the nitrate group. A correlation between lipophilicity and vasorelaxant potency could not be recognized. 2-Nitrooxyethylammoniumnitrate (1) was found to be slightly superior to the high potency trinitrate GTN.

2-nitrooxyethylammoniumnitrateNitratesChemistryStereochemistryVasodilator AgentsOrganic ChemistryClinical BiochemistryPharmaceutical ScienceVasodilationBiochemistryChemical synthesisIn vitroNo donorsQuaternary Ammonium CompoundsStructure-Activity RelationshipDrug DiscoveryLipophilicityMolecular MedicinePotencyStructure–activity relationshipNitric Oxide DonorsMolecular BiologyBioorganicmedicinal chemistry letters
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Seasonal variations of leaf area index of agricultural fields retrieved from Landsat data

2008

Abstract The derivation of leaf area index (LAI) from satellite optical data has been the subject of a large amount of work. In contrast, few papers have addressed the effective model inversion of high resolution satellite images for a complete series of data for the various crop species in a given region. The present study is focused on the assessment of a LAI model inversion approach applied to multitemporal optical data, over an agricultural region having various crop types with different crop calendars. Both the inversion approach and data sources are chosen because of their wide use. Crops in the study region (Barrax, Castilla–La Mancha, Spain) include: cereal, corn, alfalfa, sugar bee…

2. Zero hunger010504 meteorology & atmospheric sciencesPhenology0211 other engineering and technologiesSoil ScienceInverse transform samplingGeologyInversion (meteorology)02 engineering and technology15. Life on land01 natural sciencesNormalized Difference Vegetation IndexCropEnvironmental sciencePlant coverComputers in Earth SciencesLeaf area indexEmpirical relationship021101 geological & geomatics engineering0105 earth and related environmental sciencesRemote sensingRemote Sensing of Environment
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Spatio-temporal soil drying in southeastern South America: the importance of effective sampling frequency and observational errors on drydown time sc…

2020

The study of the spatio-temporal dynamics of surface soil moisture (SSM) drydowns integrates the soil response to climatic conditions, drainage and land cover and is key to advances in our knowledg...

2. Zero hunger010504 meteorology & atmospheric sciences[SDE.MCG]Environmental Sciences/Global Changes0211 other engineering and technologies02 engineering and technologyLand cover15. Life on land01 natural sciences13. Climate actionClimatologyGeneral Earth and Planetary SciencesEnvironmental scienceDrainageScale (map)Water contentSoil dryingComputingMilieux_MISCELLANEOUS021101 geological & geomatics engineering0105 earth and related environmental sciencesInternational Journal of Remote Sensing
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An agent-based model of a cutaneous leishmaniasis reservoir host, Meriones shawi

2021

International audience; Meriones shawi (M.shawi) is the main reservoir host for zoonotic cutaneous leishmaniasis (ZCL) in Central Tunisia. The incorporation of environmental and climatic effects on the spread of ZCL in M. shawi remains difficult. This study presents an agent-based model (ABM) to overcome these difficulties and examine the impact of environment (i.e. vegetation cover) and climate (i.e. temperature) on M. shawi movement and prevalence. The model simulation considers two agent types: rodent agent and field unit agent. We tested the model according to two types of rodent movement: random and thoughtful. We integrated time dependent normalized difference vegetation index (NDVI) …

2. Zero hunger0106 biological sciencesAgent-based model[SDV.EE]Life Sciences [q-bio]/Ecology environmentMeriones shawibiologyEcology010604 marine biology & hydrobiologyEcological ModelingLand covermedicine.diseasebiology.organism_classification010603 evolutionary biology01 natural sciencesNormalized Difference Vegetation IndexVegetation coverCutaneous leishmaniasis13. Climate actionModel simulationmedicineZoonotic cutaneous leishmaniasis[SDE.BE]Environmental Sciences/Biodiversity and Ecology
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Plant removal disturbance and replant mitigation effects on the abundance and diversity of low-arctic soil biota

2014

Abstract Due to the dependence of soil organisms on plant derived carbon, disturbances in plant cover are thought to be detrimental for the persistence of soil biota. In this work, we studied the disturbance effects of plant removal and soil mixing and the mitigation effects of replanting on soil biota in a low-arctic meadow ecosystem. We set up altogether six replicate blocks, each including three randomized treatment plots, at two distinct fells at Kilpisjarvi, northern Finland. Vegetation was removed in two thirds of the plots: one third was then kept barren (the plant-removal treatment), while the other third was replanted with a local herb Solidago virgaurea. The remaining plots of int…

2. Zero hungerBiomass (ecology)EcologyFaunaSoil biologyfungiSoil ScienceGrowing seasonVegetation15. Life on landBiologybiology.organism_classificationAgricultural and Biological Sciences (miscellaneous)Solidago virgaureaAgronomyPlant coverta1181EcosystemApplied Soil Ecology
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